FB2025_01 , released February 20, 2025
Allele: Dmel\arxGS12962
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General Information
Symbol
Dmel\arxGS12962
Species
D. melanogaster
Name
FlyBase ID
FBal0285568
Feature type
allele
Associated gene
Dmel\arx
Associated Insertion(s)
P{GSV6}arxGS12962
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - molecular evidence

Mutagen
    Nature of the Allele
    Allele class

    hypomorphic allele - molecular evidence

    (Muerdter et al., 2013, Ohtani et al., 2013)
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    P{GSV6}arxGS12962
    Cytology
    Description

    Insertion in the first exon.

    (Muerdter et al., 2013)
    Allele components
    Component
    Use(s)
    Inserted element
    P{GSV6}
    Regulatory region(s)
    UASt
    Mutations Mapped to the Genome
    Curation Data
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Homozygous females have rudimentary ovaries and are completely sterile.

        (Dönertas et al., 2013)

        Homozygous females have rudimentary ovaries, and are sterile.

        (Muerdter et al., 2013)

        Homozygous arxGS12962 mutant females lay no eggs. arxGS12962 mutant ovaries appear rather small and severely deformed. Ovaries lack the follicle cell layer that usually encapsulates each egg chamber. Polar cell specification is disrupted, as are oocyte polarity and specification. arxGS12962 mutant flies appear otherwise normal.

        No fertility defects are detected in arxGS12962 mutant males and testes appear normal.

        (Ohtani et al., 2013)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        Comments
        Comments

        Precise excision of the insertion reverts the female sterile phenotype.

        (Dönertas et al., 2013)
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        CG3893204406
        (Muerdter et al., 2013)
        arxGS12962
        (Yu et al., 2015)
        Name Synonyms
        Secondary FlyBase IDs
          References (4)