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General Information
Symbol
Dmel\TrpA1UAS.(A).cKa
Species
D. melanogaster
Name
FlyBase ID
FBal0285582
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-TrpA1(A), UAS-TrpA1(A)10a
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UAS regulatory sequences drive expression of a "TrpA1(A)" TrpA1 isoform containing the 10a alternative exon.

UAS regulatory sequences drive expression of the "TRPA1(A)" isoform. Note that the isoform referred to as TRPA1(A) in FBrf0222493 is similar to that called "TRPA1-D" in FBrf0217493, except that "TRPA1(A)" has an additional N-terminal amino acids.

UAS regulatory sequences drive expression of the "TrpA1(A)" TrpA1 isoform.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of TrpA1Scer\UAS.(A).cKa under the control of Scer\GAL4Gr5a.8.5 confers sensitivity to N-methylmaleimide in L-type labellar taste bristles (robust spiking is seen in a in an extracellular tip recording assay in response to 10mM N-methylmaleimide). The L-type taste bristles are not thermosensitive in these animals.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT Suppressor of
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

Expression of TrpA1Scer\UAS.(A).cKa in the arista under the control of Scer\GAL4Gr28b.d.PT does not rescue the "rapid negative thermotaxis" defects seen in Gr28bMB03888 mutant flies.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

Expression of TrpA1Scer\UAS.(A).10b under the control of Scer\GAL4TrpA1.C-D is unable to rescue the uracil-dependent defecation defect, but is able to rescue the N-methylmaleimide-dependent defecation defect of TrpA1ins mutants.

Expression of TrpA1Scer\UAS.(A).cKa under the control of Scer\GAL4Gr66a.PD restores an electrophysiological spiking response to N-methylmaleimide in berberine-sensitive i-type taste bristles in the labellum in TrpA1ins flies. Sensitivity to warming is not restored.

Expression of TrpA1Scer\UAS.(A).cKa under the control of Scer\GAL4Gr66a.PD rescues avoidance of food containing N-methylmaleimide in TrpA1ins flies.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
TrpA1A.Scer\UAS
TrpA1Scer\UAS.(A).cKa
TrpA1UAS.(A).cKa
Name Synonyms
Secondary FlyBase IDs
    References (6)