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General Information
Symbol
Dmel\Dh31UAS.ML.Tag:SS(trypsin).Tag:MYC.Tag:GPI(lynx1)
Species
D. melanogaster
Name
FlyBase ID
FBal0285826
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-t-DH31
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UAS regulates expression of a 't-peptide' comprising (from N to C terminus): a trypsin secretory signal sequence for targeting to the secretory pathway, a mature cleaved Dh31 peptide sequence, a medium length hydrophilic linker sequence of 14 amino acids with an embedded Tag:MYC epitope tag, and a GPI targeting sequence from lynx1 protoxin.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of Dh31Scer\UAS.ML.T:SS-trypsin.T:Hsap\MYC.T:GPI-lynx1 under the control of Scer\GAL4nSyb.PU significantly suppresses nighttime sleep, with the effect being strongest during the second half of the night. The nighttime sleep is less consolidated than that of controls, with the mutant flies showing more sleep bouts of shorter duration.

Expression of Dh31Scer\UAS.ML.T:SS-trypsin.T:Hsap\MYC.T:GPI-lynx1 under the control of any one of Scer\GAL4GMR18H11, Scer\GAL4GMR43D05, Scer\GAL4GMR61G12, Scer\GAL4GMR23D06, Scer\GAL4GMR23F10, Scer\GAL4GMR23H01, Scer\GAL4GMR23H02, Scer\GAL4GMR24D10, Scer\GAL4GMR24D11, Scer\GAL4GMR24E02, Scer\GAL4GMR24G08, Scer\GAL4GMR24H08, Scer\GAL4GMR25A08, Scer\GAL4GMR28D01, Scer\GAL4GMR38B06, Scer\GAL4GMR84C10, Scer\GAL4GMR10D10, Scer\GAL4GMR10G07, Scer\GAL4GMR16B04, Scer\GAL4GMR19A11, Scer\GAL4GMR34G04, Scer\GAL4GMR40F04, Scer\GAL4GMR51F10, Scer\GAL4GMR54D01, Scer\GAL4GMR67C01, Scer\GAL4Cha.7.4, Scer\GAL4Ddc.PL, Scer\GAL4Gad1.3.098, Scer\GAL4VGlut-OK371, Scer\GAL4Tdc2.PC, Scer\GAL4ple.PF, Scer\GAL4Trh.PS or Scer\GAL4tim.Scer\UAS has no effect on sleep.

Expression of Dh31Scer\UAS.ML.T:SS-trypsin.T:Hsap\MYC.T:GPI-lynx1 under the control of Scer\GAL4nSyb.PU has no effect on the strength of have free-running circadian rhythms, but results in a small decrease in the free-running period.

Scer\GAL4tim.Scer\UAS-mediated expression of Dh31Scer\UAS.ML.T:SS-trypsin.T:Hsap\MYC.T:GPI-lynx1 fails to induce free-running circadian locomotor rhythms in flies in constant darkness.

External Data
Interactions
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (3)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
Dh31Scer\UAS.ML.T:SS-trypsin.T:Hsap\MYC.T:GPI-lynx1
Dh31UAS.ML.Tag:SS(trypsin).Tag:MYC.Tag:GPI(lynx1)
Name Synonyms
Secondary FlyBase IDs
    References (5)