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General Information
Symbol
Dmel\OptixFL.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0285828
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-Optix
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference
UASt regulates expression of full-length Optix.
Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
The morphology of the optic lobe neuroepithelium is distorted in late third instar larvae expressing OptixFL.UAS under the control of Scer\GAL4Vsx1-MzVum. Expressing OptixFL.UAS under the control of either Scer\GAL4C855a or Scer\GAL4NP2631 leads to the formation of a multi-layered neuroepithelium with rosettes of rounded cells which have lost columnar apico-basal polarity in the outer optic anlage of late third instar larvae. GAL80ts was used to induce OptixFL.UAS expression between 24 and 48 hours after larval hatching. The same phenotype is observed in the outer optic anlage, eye discs and leg discs of late third instar larvae following the induction of somatic clones expressing OptixFL.UAS under the control of Scer\GAL4αTub84B.PL.
Expression of OptixFL.Scer\UAS under the control of Scer\GAL4ey.PU results in a small rough eye.
Scer\GAL4GMR.PU-mediated expression of OptixFL.Scer\UAS drastically inhibits eye development. Scer\GAL4ey.PU-mediated expression of OptixFL.Scer\UAS results in dramatic reductions in eye formation.
Expression of OptixFL.Scer\UAS via Scer\GAL4dpp.PU, Scer\GAL4rn-GAL4-5, Scer\GAL4cb49, Scer\GAL4c309 or Scer\GAL4sca-C253 yields ectopic eyes on the adult antenna, the ventral portion of the head, or the wing and haltere. Expression of OptixFL.Scer\UAS via Scer\GAL4rn-GAL4-5 results in replacement of wing tissue with retinal tissue. Expression of OptixFL.Scer\UAS via Scer\GAL4ey.PU or Scer\GAL4GMR.PU results in a severely altered eye external surface and a complete loss of photoreceptor neurons.
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
NOT Suppressor of
Statement
Reference
OptixFL.UAS/Scer\GAL4ey.PU is a non-suppressor of eye phenotype of soD
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
OptixFL.Scer\UAS
OptixFL.UAS
Name Synonyms
Secondary FlyBase IDs
    References (5)