FB2025_01 , released February 20, 2025
Allele: Dmel\perΔ.Tag:HA,Tag:polyHis
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General Information
Symbol
Dmel\perΔ.Tag:HA,Tag:polyHis
Species
D. melanogaster
Name
FlyBase ID
FBal0285855
Feature type
allele
Associated gene
Dmel\per
Associated Insertion(s)
Carried in Construct
P{perΔ.HAHis}
Also Known As
13.2(per(Δ)-HA10His)
Key Links
Transgenic product class
inframe_deletion
(Kim et al., 2007)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Kim et al., 2007)
Mutagen
in vitro construct
(Kim et al., 2007)
Progenitor genotype
P{per13.2.HA10His}
(Kim et al., 2007)
Carried in construct
P{perΔ.HAHis}
Cytology
Description

Deletion of sequences from P{per13.2.HA10His} that encode amino acids 755 to 809 of per, a region that contains the major in vivo binding domain for the dco product.

(Kim et al., 2007)
Allele components
Component
Use(s)
Regulatory region(s)
per
Encoded product / tool
per
Tagged with
Tag:HA
Tag:polyHis
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Adult per01 flies expressing perΔ.T:Ivir\HA1,T:Zzzz\His6 (rescue flies) display robust circadian activity rhythm in constant dark (preceded by an 12:12 light:dark entrainment period) with a period of about 24 hr, similarly to wild-type.

      (Yildirim et al., 2015)

      perΔ.T:Ivir\HA1,T:Zzzz\His6 flies show a significant increase in arrhythmicity above controls. For those flies displaying rhythmic activity, the amplitudes of the rhythm are strongly reduced and the periods lengthened by 3-4 hours compared to controls.

      (Kim et al., 2007)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to rescue

      perΔ.Tag:HA,Tag:polyHis fails to rescue per01

      (Kim et al., 2007)
      Comments

      perΔ.T:Ivir\HA1,T:Zzzz\His6, per01 flies are arrhythmic.

      (Kim et al., 2007)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      perΔ.T:Ivir\HA1,T:Zzzz\His6
      perΔ.Tag:HA,Tag:polyHis
      Name Synonyms
      Secondary FlyBase IDs
        References (5)