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General Information
Symbol
Dmel\discodsRNA.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0285950
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference
UAS regulates expression of three different fragments of the disco ORF (1-256bp, 607-927bp, and 1066-1515bp) that target disco RNA for RNAi-mediated degradation.
Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
Expression of discodsRNA.Scer\UAS using Scer\GAL4αTub84B.PL causes lethality at both larval and pupal (but not embryonic) stages. Expression of discodsRNA.Scer\UAS using Scer\GAL4Dll-md23 causes some lethality but allows many flies to survive. At 25[o]C, ~64% of animals survive; all escapers show antenna phenotypes characterized by shortening of the central core and deletion of most of the laterals; leg development is also defective but only 10% show deletion of the distal tarsal segments and/or the claw. When raised at 29[o]C for 4-5 days and then transferred to 25[o]C, the survival rate decreases to ~29%; now, over 70% escapers display antenna to leg transformations and the remainder display partial truncation of antennal segment 3 and arista deletion; the leg phenotype is also more severe with ~16% of escapers displaying deletion of tarsal segments 3-5 and the claw. Expression of discodsRNA.Scer\UAS using Scer\GAL4Dll-md23 does not induce cell death in antennal or leg discs.
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement
Reference
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
discodsRNA.Scer\UAS
discodsRNA.UAS
Name Synonyms
Secondary FlyBase IDs
    References (1)