FB2025_02 , released April 17, 2025
Allele: Dmel\TgiUAS.B
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General Information
Symbol
Dmel\TgiUAS.B
Species
D. melanogaster
Name
FlyBase ID
FBal0286248
Feature type
allele
Associated gene
Dmel\Tgi
Associated Insertion(s)
Carried in Construct
P{UAS-Tgi.B}
Key Links
Transgenic product class
wild_type
(Koontz et al., 2013)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Koontz et al., 2013)
Mutagen
in vitro construct
(Koontz et al., 2013)
Progenitor genotype
Carried in construct
P{UAS-Tgi.B}
Cytology
Description

UAS regulatory sequences drive expression of the RB isoform of Tgi.

(Koontz et al., 2013)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Tgi
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  Noonan syndrome
      modeled by Hsap\RAF1gof.UAS
      (Yu et al., 2015)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of TgiScer\UAS.B leads to a reduced clone size in eye and wing discs.

      (Koontz et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      TgiUAS.B has eye disc | somatic clone phenotype, suppressible by sd12

      (Koontz et al., 2013)
      NOT suppressed by
      Statement
      Reference

      TgiUAS.B has eye disc | somatic clone phenotype, non-suppressible by wtsx1

      (Koontz et al., 2013)
      Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of TgiScer\UAS.B suppresses the cardiac hypertrophy seen when ykiS168A.Scer\UAS.T:SV5\V5 is expressed under the control of Scer\GAL4tin.CΔ4.

      (Yu et al., 2015)

      sd12 suppresses the reduction in clone size seen in the eye discs of larvae expressing TgiScer\UAS.B.

      Expression of TgiScer\UAS.B suppresses the overgrowth seen in wtsx1 mutant wing disc clones, resulting in a reduced clone size compared to wild type, similar to the phenotype seen in clones expressing TgiScer\UAS.B alone.

      (Koontz et al., 2013)
      Xenogenetic Interactions
      Statement
      Reference

      Expression of TgiScer\UAS.B suppresses the cardiac hypertrophy seen in flies expressing Hsap\RAF1gof.Scer\UAS under the control of Scer\GAL4tin.CΔ4.

      (Yu et al., 2015)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      TgiScer\UAS.B
      TgiUAS.B
      Name Synonyms
      Secondary FlyBase IDs
        References (2)