Open Close
General Information
Symbol
Dmel\CG45071d07411
Species
D. melanogaster
Name
FlyBase ID
FBal0287705
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Mutagen
    Nature of the Allele
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    Associated Sequence Data
    DNA sequence
    Protein sequence
     
     
    Progenitor genotype
    Cytology
    Nature of the lesion
    Statement
    Reference

    Insertion within CG45071. Transcription levels of CG45071 are significantly reduced by the insertion.

    The P{XP}CG45071d07411 insertion maps within both CTPsyn and CG45071. CG45071 function is disrupted by the insertion: FBrf0220954 shows that transcription of CG45071 is significantly reduced in the insertion line. It is not clear whether or not CTPsyn function is affected: FBrf0220954 shows that P{XP}CG45071d07411 complements PBac{RB}CTPsyne01207 (an insertion that lies only within the CTPsyn transcription unit), suggesting that CTPsyn may be unaffected by the P{XP}CG45071d07411 insertion. However, mutant egg chamber clones show disruption in the formation of cytoophidia, indicating either that loss of CG45071 disrupts cytoophidium formation or that CTPsyn (which localises to the cytoophidium in wild type) is affected in the insertion line. FBrf0220954 also shows that there is no change in transcription of the shorter CTPsyn isoform and only a slight reduction (20%) in transcription of the longer isoform of CTPsyn in the insertion line.

    Insertion components
    P{XP}CG45071d07411
    Product class / Tool use(s)
    Encoded product / tool
    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    P{XP}CG45071d07411 mutant larvae are significantly smaller than normal. They survive until 5 days after egg deposition with very little growth. Homozygous P{XP}CG45071d07411 germline clones in the egg chamber lack detectable cytoophidia. FlyBase curator comment: it is not clear whether the mutant phenotypes of the P{XP}CG45071d07411 line are due to an effect on CTPsyn or CG45071 or both.

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Phenotype Manifest In
    Additional Comments
    Genetic Interactions
    Statement
    Reference
    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
    Comments
    Images (0)
    Mutant
    Wild-type
    Stocks (1)
    Notes on Origin
    Discoverer
    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (1)
    Reported As
    Symbol Synonym
    CG45071d07411
    Name Synonyms
    Secondary FlyBase IDs
      References (2)