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General Information
Symbol
Dmel\Zip42C.1UAS.EGFP
Species
D. melanogaster
Name
FlyBase ID
FBal0287771
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
dZip42C.1eGFP
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of Zip42C.1 which is tagged at the C-terminal end with EGFP.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of Zip42C.1Scer\UAS.T:Avic\GFP-EGFP under the control of Scer\GAL4GMR.PFa does not result in a mutant phenotype.

Expression of Zip42C.1Scer\UAS.T:Avic\GFP-EGFP under the control of Scer\GAL4pnr-MD237 does not result in a mutant phenotype.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference
NOT Enhanced by
Statement
Reference
Suppressed by
Statement
Reference
NOT suppressed by
Statement
Reference
Enhancer of
Other
Statement
Reference
Phenotype Manifest In
Enhanced by
Statement
Reference
NOT Enhanced by
Statement
Reference
Suppressed by
Statement
Reference
NOT suppressed by
Statement
Reference
Enhancer of
Suppressor of
Other
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

Expression of Zip42C.1Scer\UAS.T:Avic\GFP-EGFP under the control of Scer\GAL4Mef2.PU significantly rescues the faulty specification of fusion-competent myoblasts, and partially rescues the DA1 fusion defects of foiC887/foiC887 mutants.

Co-expression of Zip42C.1 and ZnT63CKK102261 under the control of Scer\GAL4GMR.long results in strong loss of pigmentation throughout the centre of the eye.

Co-expression of Zip42C.1Scer\UAS.T:Avic\GFP-EGFP severely exacerbates the rough eye phenotype of flies expressing Zip89BScer\UAS.T:Zzzz\FLAG under the control of Scer\GAL4GMR.long.

Co-expression of ZnT63CVDRC.cUa and Zip42C.1Scer\UAS.T:Avic\GFP-EGFP under the control of Scer\GAL4GMR.PFa results in eyes which are rough and have reduced pigmentation.

The mutant eye phenotype seen in flies co-expressing both ZnT63CVDRC.cUa and Zip42C.1Scer\UAS.T:Avic\GFP-EGFP under the control of Scer\GAL4GMR.PFa is fully rescued if the flies are also co-expressing either ZnT41FScer\UAS.T:Zzzz\FLAG or ZnT35CScer\UAS.T:Zzzz\FLAG.

The mutant eye phenotype seen in flies co-expressing both ZnT63CVDRC.cUa and Zip42C.1Scer\UAS.T:Avic\GFP-EGFP under the control of Scer\GAL4GMR.PFa is rescued if the flies are also co-expressing either ZnT77CGD2749, ZnT86DGD2913, Zip42C.2GD1831, Zip89BGD3013, Zip99CGD370 or CatsupKK103630.

The mutant eye phenotype seen in flies co-expressing both ZnT63CVDRC.cUa and Zip42C.1Scer\UAS.T:Avic\GFP-EGFP under the control of Scer\GAL4GMR.PFa is partially rescued if the flies are also co-expressing either ZnT33DScer\UAS.PB.T:Zzzz\FLAG or Zip99CScer\UAS.T:Zzzz\FLAG.

The mutant eye phenotype seen in flies co-expressing both ZnT63CVDRC.cUa and Zip42C.1Scer\UAS.T:Avic\GFP-EGFP under the control of Scer\GAL4GMR.PFa is enhanced if the flies are also co-expressing one of ZnT77CScer\UAS.T:Zzzz\FLAG, ZnT86DScer\UAS.T:Zzzz\FLAG, Zip88EScer\UAS.T:Zzzz\FLAG, Zip42C.2Scer\UAS.T:Zzzz\FLAG, foiScer\UAS.T:Zzzz\FLAG or CatsupScer\UAS.T:Zzzz\FLAG.

Co-expression of either ZnT41FGD4522, ZnT33DKK100432, ZnT35CVDRC.cUa, Zip88EVDRC.cUa or foiGD2367 has no effect on the mutant eye phenotype seen in flies co-expressing both ZnT63CVDRC.cUa and Zip42C.1Scer\UAS.T:Avic\GFP-EGFP under the control of Scer\GAL4GMR.PFa.

Co-expression of ZnT63CVDRC.cUa and Zip42C.1Scer\UAS.T:Avic\GFP-EGFP under the control of Scer\GAL4pnr-MD237 results in a mild cleft in the thorax and a significant reduction in the size of the scutellum.

The thorax defects caused by co-expression of ZnT63CVDRC.cUa and Zip42C.1Scer\UAS.T:Avic\GFP-EGFP under the control of Scer\GAL4pnr-MD237 are rescued if the flies are also co-expressing one of ZnT41FScer\UAS.T:Zzzz\FLAG, ZnT33DScer\UAS.PB.T:Zzzz\FLAG, ZnT35CScer\UAS.T:Zzzz\FLAG, Zip99CScer\UAS.T:Zzzz\FLAG or ZnT77CGD2749.

The thorax defects caused by co-expression of ZnT63CVDRC.cUa and Zip42C.1Scer\UAS.T:Avic\GFP-EGFP under the control of Scer\GAL4pnr-MD237 are enhanced if the flies are also co-expressing one of ZnT86DScer\UAS.T:Zzzz\FLAG, Zip88EScer\UAS.T:Zzzz\FLAG, foiScer\UAS.T:Zzzz\FLAG, ZnT41FGD4522, ZnT86DGD2913, Zip42C.2GD1831 or Zip99CGD370.

Co-expression of either Zip42C.2Scer\UAS.T:Zzzz\FLAG, ZnT33DKK100432, ZnT35CVDRC.cUa, Zip88EVDRC.cUa, Zip89BGD3013 or foiGD2367 has no effect on the mutant thorax phenotype seen in flies co-expressing both ZnT63CVDRC.cUa and Zip42C.1Scer\UAS.T:Avic\GFP-EGFP under the control of Scer\GAL4pnr-MD237.

The mutant eye phenotype seen in flies co-expressing both ZnT63CVDRC.cUa and Zip42C.1Scer\UAS.T:Avic\GFP-EGFP under the control of Scer\GAL4GMR.PFa is rescued if the flies are also co-expressing either ZnT41FScer\UAS.T:Avic\GFP-EGFP, ZnT35CScer\UAS.T:Avic\GFP-EGFP, ZnT33DScer\UAS.PB.T:Avic\GFP-EGFP or Zip99CScer\UAS.T:Avic\GFP-EGFP.

The mutant eye phenotype seen in flies co-expressing both ZnT63CVDRC.cUa and Zip42C.1Scer\UAS.T:Avic\GFP-EGFP under the control of Scer\GAL4GMR.PFa is enhanced if the flies are also co-expressing ZnT77CScer\UAS.T:Avic\GFP-EGFP, ZnT86DScer\UAS.T:Avic\GFP-EGFP, Zip88EScer\UAS.T:Avic\GFP-EGFP, Zip42C.2Scer\UAS.T:Avic\GFP-EGFP or CatsupScer\UAS.T:Avic\GFP-EGFP.

Co-expression of foiScer\UAS.T:Avic\GFP-EGFP has no effect on the mutant eye phenotype seen in flies co-expressing both ZnT63CVDRC.cUa and Zip42C.1Scer\UAS.T:Avic\GFP-EGFP under the control of Scer\GAL4GMR.PFa.

The mutant visible phenotype seen in flies co-expressing both ZnT63CVDRC.cUa and Zip42C.1Scer\UAS.T:Avic\GFP-EGFP under the control of Scer\GAL4GMR.PFa is rescued if the flies also carry either Df(3R)ED10639, Df(2L)ED1050 or Df(2R)ED1612.

The mutant visible phenotype seen in flies co-expressing both ZnT63CVDRC.cUa and Zip42C.1Scer\UAS.T:Avic\GFP-EGFP under the control of Scer\GAL4GMR.PFa is enhanced if the flies also carry either Df(2R)BSC889, Df(3L)BSC839 or Df(3R)BSC469.

Co-expression of ZnT41FGD4522 and Zip42C.1Scer\UAS.T:Avic\GFP-EGFP under the control of either Scer\GAL4GMR.PFa or Scer\GAL4pnr-MD237 does not result in a mutant phenotype.

Co-expression of ZnT63CVDRC.cUa and Zip42C.1Scer\UAS.T:Avic\GFP-EGFP under the control of Scer\GAL4GMR.PFa results in a rough eye phenotype and loss of eye pigmentation. This phenotype is enhanced in a dose-dependent manner by the addition of zinc chloride to the food medium and is suppressed in a dose-dependent manner by the addition of TPEN to the food medium.

Co-expression of ZnT63CVDRC.cUa and Zip42C.1Scer\UAS.T:Avic\GFP-EGFP under the control of Scer\GAL4pnr-MD237 results in scutellum loss, a thoracic cleft, loss of cuticle pigmentation and thoracic bristle misalignment. This phenotype is enhanced in a dose-dependent manner by the addition of zinc chloride to the food medium, resulting in the formation of large melanotic masses, which are primarily seen in the abdominal region. The phenotype is suppressed by the addition of TPEN to the food medium.

Co-expression of ZnT35CVDRC.cUa and Zip42C.1Scer\UAS.T:Avic\GFP-EGFP under the control of either Scer\GAL4GMR.PFa or Scer\GAL4pnr-MD237 does not result in a mutant phenotype.

Co-expression of ZnT77CGD2749 and Zip42C.1Scer\UAS.T:Avic\GFP-EGFP under the control of Scer\GAL4GMR.PFa does not result in a mutant phenotype.

Co-expression of ZnT77CGD2749 and Zip42C.1Scer\UAS.T:Avic\GFP-EGFP under the control of Scer\GAL4pnr-MD237 results in sporadic abdominal cuticle defects.

Co-expression of ZnT86DVDRC.cUa and Zip42C.1Scer\UAS.T:Avic\GFP-EGFP under the control of either Scer\GAL4GMR.PFa or Scer\GAL4pnr-MD237 does not result in a mutant phenotype.

Co-expression of Zip88EScer\UAS.T:Zzzz\FLAG and Zip42C.1Scer\UAS.T:Avic\GFP-EGFP under the control of either Scer\GAL4GMR.PFa or Scer\GAL4pnr-MD237 does not result in a mutant phenotype.

Co-expression of Zip42C.2Scer\UAS.T:Zzzz\FLAG and Zip42C.1Scer\UAS.T:Avic\GFP-EGFP under the control of Scer\GAL4GMR.PFa results in a mild rough eye phenotype.

Co-expression of Zip42C.2Scer\UAS.T:Zzzz\FLAG and Zip42C.1Scer\UAS.T:Avic\GFP-EGFP under the control of Scer\GAL4pnr-MD237 results in a reduced scutellum, a mild thoracic cleft and abnormal thoracic bristle alignment.

Co-expression of Zip89BScer\UAS.T:Zzzz\FLAG and Zip42C.1Scer\UAS.T:Avic\GFP-EGFP under the control of Scer\GAL4GMR.PFa results in a flattened eye.

Co-expression of foiScer\UAS.T:Zzzz\FLAG and Zip42C.1Scer\UAS.T:Avic\GFP-EGFP under the control of either Scer\GAL4GMR.PFa or Scer\GAL4pnr-MD237 does not result in a mutant phenotype.

Co-expression of Zip99CScer\UAS.T:Zzzz\FLAG and Zip42C.1Scer\UAS.T:Avic\GFP-EGFP under the control of Scer\GAL4GMR.PFa does not result in a mutant phenotype.

Co-expression of Zip99CScer\UAS.T:Zzzz\FLAG and Zip42C.1Scer\UAS.T:Avic\GFP-EGFP under the control of Scer\GAL4pnr-MD237 results in abnormal thoracic bristle development.

Co-expression of CatsupScer\UAS.cLa.T:Zzzz\FLAG and Zip42C.1Scer\UAS.T:Avic\GFP-EGFP under the control of either Scer\GAL4GMR.PFa or Scer\GAL4pnr-MD237 does not result in a mutant phenotype.

Xenogenetic Interactions
Statement
Reference

Co-expression of BacA\p35Scer\UAS.cUa mildly exacerbates the eye defects caused by co-expression of ZnT63CVDRC.cUa and Zip42C.1Scer\UAS.T:Avic\GFP-EGFP under the control of Scer\GAL4GMR.PFa.

Co-expression of BacA\p35Scer\UAS.cUa exacerbates the thoracic midline defects caused by co-expression of ZnT63CVDRC.cUa and Zip42C.1Scer\UAS.T:Avic\GFP-EGFP under the control of Scer\GAL4pnr-MD237.

Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
Reported As
Symbol Synonym
Zip42C.1Scer\UAS.T:Avic\GFP-EGFP
Zip42C.1UAS.EGFP
dZIP42C.1eGFP
Name Synonyms
Secondary FlyBase IDs
    References (6)