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General Information
Symbol
Dmel\Atg1UAS.cTa
Species
D. melanogaster
Name
FlyBase ID
FBal0287781
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-unc-51WT
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

Expression of Atg1 cDNA (LD18893) is under the control of UAS sequences.

UAS regulatory sequences drive expression of wild-type Atg1.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Evoked excitatory junction potentials at the neuromuscular junctions of Atg1Scer\UAS.cWa; Scer\GAL4elav.PLu larvae are significantly decreased compared to wild-type.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement
Reference
Phenotype Manifest In
Enhancer of
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

The wing nicking phenotype caused by expression of domdsRNA.Sym.Scer\UAS under the control of Scer\GAL4bbg-C96 is enhanced if the flies are also co-expressing Atg1Scer\UAS.cTa.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

Atg1Scer\UAS.cWa; Scer\GAL4elav.PLu rescues the structural phenotypes seen in the neuromuscular junctions (NMJ) of Atg13 homozygous larvae: NMJ size, puncta density and apposition of pre and post-synaptic components are all restored. However, neurophysiological defects in these NMJs are not rescued. Neither neurophysiological nor structural defects in these NMJs are rescued when a post-synaptic driver, Scer\GAL4G7, is used in place of Atg1Scer\UAS.cWa.

The axonal transport defect seen in Atg13/Atg125 larvae is rescued by expression of Atg1Scer\UAS.cTa under the control of Scer\GAL4elav-C155.

Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (7)
Reported As
Symbol Synonym
Atg1Scer\UAS.cTa
Atg1Scer\UAS.cWa
Atg1UAS.cTa
unc-513-rescue
Name Synonyms
Saccharomyces cerevisiae UAS construct a of Toda
Saccharomyces cerevisiae UAS construct of Wairkar
Secondary FlyBase IDs
  • FBal0221026
  • FBal0220539
References (5)