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General Information
Symbol
Dmel\Usp8DN.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0287822
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of a dominant negative form of Usp8 (contains the amino acid replacement C572A).

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

95% of flies expressing UbpyDN.Scer\UAS under the control of Scer\GAL4P2.4.Pdf have a robust locomotor activity rhythm with a 25 hour period, approximately 1.5 hours longer than controls.

Only 58.3% of flies expressing UbpyDN.Scer\UAS under the control of Scer\GAL4Dvir\Pdf.1.9 show rhythmic locomotor activity at 25[o]C and only 8% are rhythmic at 29[o]C.

Expression of UbpyDN.Scer\UAS under the control of Scer\GAL4tim.PE limited to the adult stage (using the temperature sensitive Scer\GAL80ts.αTub84B allele to limit expression) results in a reduction in the fraction of flies with rhythmic locomotor activity, and the remaining rhythmic flies have very weak rhythms.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
UbpyDN.Scer\UAS
Usp8DN.Scer\UAS
Usp8DN.UAS
Name Synonyms
Secondary FlyBase IDs
    References (1)