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General Information
Symbol
Dmel\Rpp3018.2
Species
D. melanogaster
Name
FlyBase ID
FBal0287883
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
18.2
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Nucleotide change:

T252010C

Amino acid change:

L83P | Rpp30-PB; L83P | Rpp30-PA

Reported amino acid change:

L83P

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Amino acid replacement: L83P.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

10% of homozygotes survive to adulthood at 25[o]C, and 20% survive at 18[o]C. Homozygous and Rpp3018.2/Rpp30k01901 flies are normal in size.

Homozygous ovaries are rudimentary due to oogenesis arrest at an early stage of development. Homozygous clones in the germline result in egg chambers that arrest as early as in homozygous mutant ovaries, whereas egg chambers in which all follicle cells are homozygous develop normally.

Egg chambers containing coconut18.2 mutant germline clones arrest oogenesis at stage 4-5. In some cases the oocyte is mislocalised within the egg chamber. Oogenesis arrests slightly earlier in homozygous coconut18.2 mutant escapers.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT suppressed by
Statement
Reference

Rpp3018.2 has sterile phenotype, non-suppressible by p5311-1B-1

Other
Statement
Reference
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

Some egg chambers are found developing to late stages of oogenesis or even forming eggs in Rpp3018.2 ; p5311-1B-1 double mutant females. This rescue is partial, as the majority of egg chambers are still arrested early and the flies are still sterile.

Most egg chambers develop into eggs in Rpp3018.2 ; lokp6 double mutant females, and these eggs can be laid and fertilised.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (3)