FB2025_01 , released February 20, 2025
Allele: Dmel\rhea6-66
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General Information
Symbol
Dmel\rhea6-66
Species
D. melanogaster
Name
FlyBase ID
FBal0288472
Feature type
allele
Associated gene
Dmel\rhea
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Ghabrial et al., 2011)
Progenitor genotype
Cytology
Description

Nucleotide substitution: C?T.

(Ghabrial et al., 2011)

Amino acid replacement: Q1250term.

(Ghabrial et al., 2011, Levi et al., 2006)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3L:8,566,299..8,566,299 [+]
Nucleotide change:

C8566299T

Amino acid change:

Q1250term | rhea-PB; Q1250term | rhea-PC; Q1250term | rhea-PD; Q1250term | rhea-PE; Q1250term | rhea-PF; Q1229term | rhea-PG; Q1250term | rhea-PH

Reported amino acid change:

Q1250term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Levi et al., 2006)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      rhea6-66 mutants exhibit terminal cell pruning with multiple convoluted lumens.

      (Ghabrial et al., 2011)

      In rhea6-66 dorsal branch terminal cell clones in third instar larvae have ~90% fewer terminal branches than wild-type clones. Almost every terminal cell lumen of the rhea6-66 clones appears convoluted and all branches contain multiple lumens. When individual rhea6-66 clones are imaged in live early third instar larvae and again 48 hours later, terminal branches are lost or collapsed as the multi-lumen defect becomes more prominent. Lumens are often displaced from branches before the branch is completely lost.

      (Levi et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      rhea[+]/rhea6-66 is a suppressor of male germline stem cell phenotype of Socs36EPZ1647

      (Issigonis et al., 2009)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Based on the extent of the tracheal luminal phenotype, the following rhea alleles can be ranked from weakest to strongest: rhea15-39 < rhea14-69 < rhea6-66 < rhea13-8.

      (Levi et al., 2006)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      666
      (Ghabrial et al., 2011)
      rhea6-66
      (Issigonis et al., 2009)
      rhea666
      (Ghabrial et al., 2011)
      tendrils6-66
      (Levi et al., 2006, Levi et al., 2006)
      Name Synonyms
      Secondary FlyBase IDs
      • FBal0268684
      • FBal0193599
      References (4)