FlyBase Allele Report: Ncra\QF[QF2.nSyb]

General Information

Symbol

Ncra\QF^QF2.nSyb

Species

N. crassa

Name

FlyBase ID

FBal0288660

Feature type

allele

Associated gene

Ncra\QF

Associated Insertion(s)

Carried in Construct

M{nSyb-QF2.P}

P{nSyb-QF2.P}

Also Known As

nsyb-QF2, Syb-QF2, nSybQF2, n-syb-QF2

Transgenic product class

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

Mutagen

in vitro construct

(Riabinina et al., 2015, Riabinina and Potter, 2013.10.1)

Progenitor genotype

Carried in construct

M{nSyb-QF2.P}

P{nSyb-QF2.P}

Cytology

Description

nSyb promoter sequences regulate expression of the QF2 driver (a derivative of QF in which the middle domain is completely deleted).

(Riabinina et al., 2015)

nSyb regulatory sequences control expression of a QF2 driver (a less toxic variant of QF).

(Riabinina and Potter, 2013.10.1)

Allele components

Component

Use(s)

Regulatory region(s)

nSyb

Encoded product / tool

QF2

binary expression system - driver

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

distribution deduced from reporter (Gal4 UAS)

Stage

Tissue/Position (including subcellular localization)

Reference

larval stage -- adult stage

neuron

(Riabinina et al., 2015)

Additional Information

Statement

Reference

NcraQF^QF2.nSyb drives pan-neuronal expression.

(Riabinina et al., 2015)

Marker for

Reflects expression of

nSyb

(Riabinina et al., 2015)

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal locomotor behavior | adult stage, with Hsap\SNCA^QUAS.cOa

(Sarkar et al., 2021, Sarkar et al., 2020, Ordonez et al., 2018)

abnormal neuroanatomy | adult stage, with Hsap\MAPT^{P301L.QUAS.0N4R}

(Praschberger et al., 2023)

abnormal neurophysiology | adult stage | progressive, with Hsap\MAPT^{P301L.QUAS.0N4R}

(Praschberger et al., 2023)

abnormal size | adult stage, with Hsap\SNCA^QUAS.cOa

(Ordonez et al., 2018)

abnormal sleep | adult stage | progressive, with Hsap\MAPT^{P301L.QUAS.0N4R}

(Praschberger et al., 2023)

decreased cell number, with Hsap\SNCA^QUAS.cOa

(Parkhitko et al., 2020)

decreased cell number | adult stage, with Hsap\SNCA^QUAS.cOa

(Sarkar et al., 2021, Ordonez et al., 2018)

decreased sleep | adult stage, with Hsap\MAPT^{P301L.QUAS.0N4R}

(Praschberger et al., 2023)

increased cell death | adult stage, with Hsap\SNCA^QUAS.cOa

(Ordonez et al., 2018)

lethal | heat sensitive, with shi^ts1.QUAS

(Riabinina et al., 2015)

short lived, with Hsap\SNCA^QUAS.cOa

(Ordonez et al., 2018)

viable, with Ncra\QS^αTub84B.PP, shi^ts1.QUAS

(Riabinina et al., 2015)

Phenotype Manifest In

adult brain, with Hsap\MAPT^{P301L.QUAS.0N4R}

(Praschberger et al., 2023)

adult brain, with Hsap\SNCA^A53T.QUAS

(Praschberger et al., 2023)

adult brain, with Hsap\SNCA^QUAS.cOa

(Ordonez et al., 2018)

adult neuron | decreased number, with Hsap\SNCA^QUAS.cOa

(Parkhitko et al., 2020)

centrifugal neuron C2, with Hsap\MAPT^{P301L.QUAS.0N4R}

(Praschberger et al., 2023)

dopaminergic medulla neuron, with Hsap\SNCA^QUAS.cOa

(Ordonez et al., 2018)

dopaminergic medulla neuron | adult stage | decreased number, with Hsap\SNCA^QUAS.cOa

(Sarkar et al., 2021)

filamentous actin | adult stage, with Hsap\SNCA^QUAS.cOa

(Ordonez et al., 2018)

medulla, with Hsap\SNCA^QUAS.cOa

(Parkhitko et al., 2020, Ordonez et al., 2018)

medullary intrinsic neuron | adult stage | decreased number, with Hsap\SNCA^QUAS.cOa

(Sarkar et al., 2021)

mitochondrion | adult stage, with Hsap\SNCA^QUAS.cOa

(Ordonez et al., 2018)

neuron | adult stage, with Hsap\SNCA^QUAS.cOa

(Ordonez et al., 2018)

outer medulla | adult stage, with Hsap\SNCA^QUAS.cOa

(Sarkar et al., 2021)

retina | adult stage, with Hsap\MAPT^{P301L.QUAS.0N4R}

(Praschberger et al., 2023)

transmedullary neuron Tm3, with Hsap\MAPT^{P301L.QUAS.0N4R}

(Praschberger et al., 2023)

vacuole | adult stage | increased number, with Hsap\MAPT^{P301L.QUAS.0N4R}

(Praschberger et al., 2023)

vacuole | adult stage | increased number, with Hsap\SNCA^A53T.QUAS

(Praschberger et al., 2023)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has abnormal locomotor behavior | adult stage phenotype, enhanceable by Hsap\LRRK2^UAS.cVa/Scer\GAL4^nSyb.PP

(Sarkar et al., 2021)

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has decreased cell number | adult stage phenotype, enhanceable by Hsap\LRRK2^UAS.cVa/Scer\GAL4^nSyb.PP

(Sarkar et al., 2021)

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has abnormal locomotor behavior | adult stage phenotype, enhanceable by Lrrk^e03680/Lrrk^e03680

(Sarkar et al., 2021)

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has decreased cell number | adult stage phenotype, enhanceable by Lrrk^e03680/Lrrk^e03680

(Sarkar et al., 2021)

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has abnormal locomotor behavior | adult stage phenotype, enhanceable by Lrrk^RNAi.UAS.cIa/Scer\GAL4^nSyb.PP

(Sarkar et al., 2021)

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has decreased cell number | adult stage phenotype, enhanceable by Lrrk^RNAi.UAS.cIa/Scer\GAL4^nSyb.PP

(Sarkar et al., 2021)

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has abnormal locomotor behavior | adult stage phenotype, enhanceable by Scer\GAL4^nSyb.PP/Lrrk^I1915T.UAS

(Sarkar et al., 2021)

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has decreased cell number | adult stage phenotype, enhanceable by Scer\GAL4^nSyb.PP/Lrrk^I1915T.UAS

(Sarkar et al., 2021)

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has abnormal locomotor behavior | adult stage phenotype, enhanceable by Scer\GAL4^nSyb.PP/Lrrk^G1914S.UAS

(Sarkar et al., 2021)

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has decreased cell number | adult stage phenotype, enhanceable by Scer\GAL4^nSyb.PP/Lrrk^G1914S.UAS

(Sarkar et al., 2021)

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has abnormal locomotor behavior | adult stage phenotype, enhanceable by Scer\GAL4^nSyb.PP/Lrrk^UAS.cIa

(Sarkar et al., 2021)

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has decreased cell number | adult stage phenotype, enhanceable by Scer\GAL4^nSyb.PP/Lrrk^UAS.cIa

(Sarkar et al., 2021)

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has abnormal locomotor behavior | adult stage phenotype, enhanceable by Scer\GAL4^nSyb.PP/Lrrk^Y1383C.UAS

(Sarkar et al., 2021)

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has decreased cell number | adult stage phenotype, enhanceable by Scer\GAL4^nSyb.PP/Lrrk^Y1383C.UAS

(Sarkar et al., 2021)

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has abnormal locomotor behavior | adult stage phenotype, enhanceable by Scer\GAL4^nSyb.PP/Lrrk^R1069G.UAS

(Sarkar et al., 2021)

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has decreased cell number | adult stage phenotype, enhanceable by Scer\GAL4^nSyb.PP/Lrrk^R1069G.UAS

(Sarkar et al., 2021)

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has abnormal locomotor behavior | adult stage phenotype, enhanceable by Scer\GAL4^nSyb.PP/Lrrk^3KD.UAS

(Sarkar et al., 2021)

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has decreased cell number | adult stage phenotype, enhanceable by Scer\GAL4^nSyb.PP/Lrrk^3KD.UAS

(Sarkar et al., 2021)

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has abnormal locomotor behavior | adult stage phenotype, enhanceable by Pu^HMC04085/Scer\GAL4^nSyb.PU

(Sarkar et al., 2020)

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has abnormal locomotor behavior | adult stage phenotype, enhanceable by Scer\GAL4^nSyb.PU/Pu^HMS02399

(Sarkar et al., 2020)

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has abnormal locomotor behavior | adult stage phenotype, enhanceable by Scer\GAL4^elav-C155/Act5C^UASp.R.GFP

(Ordonez et al., 2018)

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has decreased cell number | adult stage phenotype, enhanceable by Scer\GAL4^elav-C155/Act5C^UASp.R.GFP

(Ordonez et al., 2018)

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has abnormal locomotor behavior | adult stage phenotype, enhanceable by Scer\GAL4^elav-C155/Hsap\MAPT^UAS.cWa

(Ordonez et al., 2018)

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has decreased cell number | adult stage phenotype, enhanceable by Scer\GAL4^elav-C155/Hsap\MAPT^UAS.cWa

(Ordonez et al., 2018)

NOT Enhanced by

Statement

Reference

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has abnormal locomotor behavior | adult stage phenotype, non-enhanceable by Pu^HMC04085/Scer\GAL4^repo.PU

(Sarkar et al., 2020)

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has abnormal locomotor behavior | adult stage phenotype, non-enhanceable by Pu^HMS02399/Scer\GAL4^repo.PU

(Sarkar et al., 2020)

Suppressed by

Statement

Reference

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has decreased cell number | adult stage phenotype, suppressible by Lrrk^Q1003H.UAS/Scer\GAL4^nSyb.PP

(Sarkar et al., 2021)

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has abnormal locomotor behavior | adult stage phenotype, suppressible by Lrrk^Q1003H.UAS/Scer\GAL4^nSyb.PP

(Sarkar et al., 2021)

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has abnormal locomotor behavior | adult stage phenotype, suppressible by Act5C^G0010/Act5C[+]

(Ordonez et al., 2018)

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has abnormal locomotor behavior | adult stage phenotype, suppressible by Scer\GAL4^elav-C155/Fhos^HMJ21037

(Ordonez et al., 2018)

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has abnormal locomotor behavior | adult stage phenotype, suppressible by Scer\GAL4^elav-C155/Drp1^UAS.cDb

(Ordonez et al., 2018)

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has decreased cell number | adult stage phenotype, suppressible by Act5C^G0010/Act5C[+]

(Ordonez et al., 2018)

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has decreased cell number | adult stage phenotype, suppressible by Scer\GAL4^elav-C155/Fhos^HMJ21037

(Ordonez et al., 2018)

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has decreased cell number | adult stage phenotype, suppressible by Scer\GAL4^elav-C155/Drp1^UAS.cDb

(Ordonez et al., 2018)

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has abnormal size | adult stage phenotype, suppressible by Act5C^G0010/Act5C[+]

(Ordonez et al., 2018)

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has abnormal size | adult stage phenotype, suppressible by Scer\GAL4^elav-C155/Fhos^HMJ21037

(Ordonez et al., 2018)

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has abnormal size | adult stage phenotype, suppressible by Scer\GAL4^elav-C155/Gel^UAS.cDa

(Ordonez et al., 2018)

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has abnormal locomotor behavior | adult stage phenotype, suppressible by Scer\GAL4^elav-C155/α-Spec^UAS.Tag:MYC

(Ordonez et al., 2018)

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has decreased cell number | adult stage phenotype, suppressible by Scer\GAL4^elav-C155/α-Spec^UAS.Tag:MYC

(Ordonez et al., 2018)

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has abnormal size | adult stage phenotype, suppressible by Scer\GAL4^elav-C155/α-Spec^UAS.Tag:MYC

(Ordonez et al., 2018)

NOT suppressed by

Statement

Reference

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has decreased cell number phenotype, non-suppressible by Tat^HMC03212/Scer\GAL4^elav.PU

(Parkhitko et al., 2020)

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has decreased cell number phenotype, non-suppressible by Scer\GAL4^elav.PU/Tat^HMS05690

(Parkhitko et al., 2020)

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has decreased cell number phenotype, non-suppressible by Tat^HMS05877/Scer\GAL4^elav.PU

(Parkhitko et al., 2020)

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has abnormal locomotor behavior | adult stage phenotype, non-suppressible by Pu^HMS02399/Scer\GAL4^repo.PU

(Sarkar et al., 2020)

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has abnormal locomotor behavior | adult stage phenotype, non-suppressible by Pu^HMC04085/Scer\GAL4^repo.PU

(Sarkar et al., 2020)

Enhancer of

Statement

Reference

Hsap\SNCA^QUAS.cOa/Ncra\QF^QF2.nSyb is an enhancer of abnormal locomotor behavior | adult stage phenotype of Hsap\MAPT^UAS.cWa, Scer\GAL4^elav-C155

(Ordonez et al., 2018)

Suppressor of

Statement

Reference

Ncra\QF^QF2.nSyb/spz3^QUAS.EGFP is a suppressor | partially of abnormal neuroanatomy | third instar larval stage phenotype of αSnap^KK107910, Hsim\VP16^AD.nrv2, Scer\GAL4^{DBD.wrapper.932i}

(Coutinho-Budd et al., 2017)

Other

Statement

Reference

Hsap\MAPT^UAS.cWa, Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb, Scer\GAL4^elav-C155 has viable phenotype

(Ordonez et al., 2018)

α-Spec^lm88, Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has lethal phenotype

(Ordonez et al., 2018)

α-Spec^MI11816, Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has lethal phenotype

(Ordonez et al., 2018)

Hsap\MAPT^R406W.UAS, Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb, Scer\GAL4^elav-C155 has lethal phenotype

(Ordonez et al., 2018)

α-Spec^rg41, Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has lethal phenotype

(Ordonez et al., 2018)

Phenotype Manifest In

Enhanced by

Statement

Reference

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has outer medulla | adult stage phenotype, enhanceable by Hsap\LRRK2^UAS.cVa/Scer\GAL4^nSyb.PP

(Sarkar et al., 2021)

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has medullary intrinsic neuron | adult stage | decreased number phenotype, enhanceable by Hsap\LRRK2^UAS.cVa/Scer\GAL4^nSyb.PP

(Sarkar et al., 2021)

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has dopaminergic medulla neuron | adult stage | decreased number phenotype, enhanceable by Hsap\LRRK2^UAS.cVa/Scer\GAL4^nSyb.PP

(Sarkar et al., 2021)

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has outer medulla | adult stage phenotype, enhanceable by Lrrk^e03680/Lrrk^e03680

(Sarkar et al., 2021)

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has medullary intrinsic neuron | adult stage | decreased number phenotype, enhanceable by Lrrk^e03680/Lrrk^e03680

(Sarkar et al., 2021)

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has dopaminergic medulla neuron | adult stage | decreased number phenotype, enhanceable by Lrrk^e03680/Lrrk^e03680

(Sarkar et al., 2021)

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has outer medulla | adult stage phenotype, enhanceable by Lrrk^RNAi.UAS.cIa/Scer\GAL4^nSyb.PP

(Sarkar et al., 2021)

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has medullary intrinsic neuron | adult stage | decreased number phenotype, enhanceable by Lrrk^RNAi.UAS.cIa/Scer\GAL4^nSyb.PP

(Sarkar et al., 2021)

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has dopaminergic medulla neuron | adult stage | decreased number phenotype, enhanceable by Lrrk^RNAi.UAS.cIa/Scer\GAL4^nSyb.PP

(Sarkar et al., 2021)

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has outer medulla | adult stage phenotype, enhanceable by Scer\GAL4^nSyb.PP/Lrrk^I1915T.UAS

(Sarkar et al., 2021)

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has medullary intrinsic neuron | adult stage | decreased number phenotype, enhanceable by Scer\GAL4^nSyb.PP/Lrrk^I1915T.UAS

(Sarkar et al., 2021)

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has dopaminergic medulla neuron | adult stage | decreased number phenotype, enhanceable by Scer\GAL4^nSyb.PP/Lrrk^I1915T.UAS

(Sarkar et al., 2021)

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has outer medulla | adult stage phenotype, enhanceable by Scer\GAL4^nSyb.PP/Lrrk^G1914S.UAS

(Sarkar et al., 2021)

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has medullary intrinsic neuron | adult stage | decreased number phenotype, enhanceable by Scer\GAL4^nSyb.PP/Lrrk^G1914S.UAS

(Sarkar et al., 2021)

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has dopaminergic medulla neuron | adult stage | decreased number phenotype, enhanceable by Scer\GAL4^nSyb.PP/Lrrk^G1914S.UAS

(Sarkar et al., 2021)

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has outer medulla | adult stage phenotype, enhanceable by Scer\GAL4^nSyb.PP/Lrrk^UAS.cIa

(Sarkar et al., 2021)

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has medullary intrinsic neuron | adult stage | decreased number phenotype, enhanceable by Scer\GAL4^nSyb.PP/Lrrk^UAS.cIa

(Sarkar et al., 2021)

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has dopaminergic medulla neuron | adult stage | decreased number phenotype, enhanceable by Scer\GAL4^nSyb.PP/Lrrk^UAS.cIa

(Sarkar et al., 2021)

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has outer medulla | adult stage phenotype, enhanceable by Scer\GAL4^nSyb.PP/Lrrk^Y1383C.UAS

(Sarkar et al., 2021)

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has medullary intrinsic neuron | adult stage | decreased number phenotype, enhanceable by Scer\GAL4^nSyb.PP/Lrrk^Y1383C.UAS

(Sarkar et al., 2021)

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has dopaminergic medulla neuron | adult stage | decreased number phenotype, enhanceable by Scer\GAL4^nSyb.PP/Lrrk^Y1383C.UAS

(Sarkar et al., 2021)

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has outer medulla | adult stage phenotype, enhanceable by Scer\GAL4^nSyb.PP/Lrrk^R1069G.UAS

(Sarkar et al., 2021)

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has medullary intrinsic neuron | adult stage | decreased number phenotype, enhanceable by Scer\GAL4^nSyb.PP/Lrrk^R1069G.UAS

(Sarkar et al., 2021)

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has dopaminergic medulla neuron | adult stage | decreased number phenotype, enhanceable by Scer\GAL4^nSyb.PP/Lrrk^R1069G.UAS

(Sarkar et al., 2021)

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has adult brain phenotype, enhanceable by Scer\GAL4^elav-C155/Act5C^UASp.R.GFP

(Ordonez et al., 2018)

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has neuron | adult stage phenotype, enhanceable by Scer\GAL4^elav-C155/Hsap\MAPT^UAS.cWa

(Ordonez et al., 2018)

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has dopaminergic medulla neuron phenotype, enhanceable by Scer\GAL4^elav-C155/Hsap\MAPT^UAS.cWa

(Ordonez et al., 2018)

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has filamentous actin | adult stage phenotype, enhanceable by Scer\GAL4^elav-C155/Hsap\MAPT^UAS.cWa

(Ordonez et al., 2018)

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has medulla phenotype, enhanceable by Scer\GAL4^elav-C155/Hsap\MAPT^UAS.cWa

(Ordonez et al., 2018)

Suppressed by

Statement

Reference

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has dopaminergic medulla neuron | adult stage | decreased number phenotype, suppressible by Lrrk^Q1003H.UAS/Scer\GAL4^nSyb.PP

(Sarkar et al., 2021)

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has outer medulla | adult stage phenotype, suppressible by Lrrk^Q1003H.UAS/Scer\GAL4^nSyb.PP

(Sarkar et al., 2021)

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has medullary intrinsic neuron | adult stage | decreased number phenotype, suppressible by Lrrk^Q1003H.UAS/Scer\GAL4^nSyb.PP

(Sarkar et al., 2021)

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has dopaminergic medulla neuron | adult stage | decreased number phenotype, suppressible by Scer\GAL4^nSyb.PP/Lrrk^3KD.UAS

(Sarkar et al., 2021)

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has outer medulla | adult stage phenotype, suppressible by Scer\GAL4^nSyb.PP/Lrrk^3KD.UAS

(Sarkar et al., 2021)

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has medullary intrinsic neuron | adult stage | decreased number phenotype, suppressible by Scer\GAL4^nSyb.PP/Lrrk^3KD.UAS

(Sarkar et al., 2021)

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has adult brain phenotype, suppressible by Act5C^G0010/Act5C[+]

(Ordonez et al., 2018)

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has adult brain phenotype, suppressible by Scer\GAL4^elav-C155/Fhos^HMJ21037

(Ordonez et al., 2018)

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has adult brain phenotype, suppressible by Scer\GAL4^elav-C155/Drp1^UAS.cDb

(Ordonez et al., 2018)

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has neuron | adult stage phenotype, suppressible by Act5C^G0010/Act5C[+]

(Ordonez et al., 2018)

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has neuron | adult stage phenotype, suppressible by Scer\GAL4^elav-C155/Fhos^HMJ21037

(Ordonez et al., 2018)

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has neuron | adult stage phenotype, suppressible by Scer\GAL4^elav-C155/Drp1^UAS.cDb

(Ordonez et al., 2018)

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has neuron | adult stage phenotype, suppressible by Scer\GAL4^elav-C155/α-Spec^UAS.Tag:MYC

(Ordonez et al., 2018)

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has dopaminergic medulla neuron phenotype, suppressible by Act5C^G0010/Act5C[+]

(Ordonez et al., 2018)

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has dopaminergic medulla neuron phenotype, suppressible by Scer\GAL4^elav-C155/Fhos^HMJ21037

(Ordonez et al., 2018)

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has dopaminergic medulla neuron phenotype, suppressible by Scer\GAL4^elav-C155/Drp1^UAS.cDb

(Ordonez et al., 2018)

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has dopaminergic medulla neuron phenotype, suppressible by Scer\GAL4^elav-C155/α-Spec^UAS.Tag:MYC

(Ordonez et al., 2018)

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has filamentous actin | adult stage phenotype, suppressible by Act5C^G0010/Act5C[+]

(Ordonez et al., 2018)

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has filamentous actin | adult stage phenotype, suppressible by Scer\GAL4^elav-C155/Fhos^HMJ21037

(Ordonez et al., 2018)

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has filamentous actin | adult stage phenotype, suppressible by Scer\GAL4^elav-C155/α-Spec^UAS.Tag:MYC

(Ordonez et al., 2018)

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has mitochondrion | adult stage phenotype, suppressible by Act5C^G0010/Act5C[+]

(Ordonez et al., 2018)

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has mitochondrion | adult stage phenotype, suppressible by Scer\GAL4^elav-C155/Fhos^HMJ21037

(Ordonez et al., 2018)

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has mitochondrion | adult stage phenotype, suppressible by Scer\GAL4^elav-C155/Gel^UAS.cDa

(Ordonez et al., 2018)

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has mitochondrion | adult stage phenotype, suppressible by Scer\GAL4^elav-C155/Drp1^UAS.cDb

(Ordonez et al., 2018)

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has mitochondrion | adult stage phenotype, suppressible by Scer\GAL4^elav-C155/α-Spec^UAS.Tag:MYC

(Ordonez et al., 2018)

NOT suppressed by

Statement

Reference

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has adult neuron | decreased number phenotype, non-suppressible by Tat^HMC03212/Scer\GAL4^elav.PU

(Parkhitko et al., 2020)

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has adult neuron | decreased number phenotype, non-suppressible by Scer\GAL4^elav.PU/Tat^HMS05690

(Parkhitko et al., 2020)

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has adult neuron | decreased number phenotype, non-suppressible by Tat^HMS05877/Scer\GAL4^elav.PU

(Parkhitko et al., 2020)

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has medulla phenotype, non-suppressible by Tat^HMC03212/Scer\GAL4^elav.PU

(Parkhitko et al., 2020)

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has medulla phenotype, non-suppressible by Tat^HMS05877/Scer\GAL4^elav.PU

(Parkhitko et al., 2020)

Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb has medulla phenotype, non-suppressible by Scer\GAL4^elav.PU/Tat^HMS05690

(Parkhitko et al., 2020)

Suppressor of

Statement

Reference

Ncra\QF^QF2.nSyb/spz3^QUAS.EGFP is a suppressor | partially of embryonic/larval cell body glial cell | third instar larval stage phenotype of αSnap^KK107910, Hsim\VP16^AD.nrv2, Scer\GAL4^{DBD.wrapper.932i}

(Coutinho-Budd et al., 2017)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescues

Ncra\QF^QF2.nSyb/spz3^QUAS.EGFP partially rescues spz3^KK106772

(Coutinho-Budd et al., 2017)

Comments

Images (0)

Mutant

Wild-type

Stocks (10)

Bloomington

78338

y¹ w¹¹¹⁸; P{nSyb-QF2.P}attP2/TM6B, Tb¹

51955

y¹ w¹¹¹⁸; M{nSyb-QF2.P}ZH-86Fb/TM6B, Tb¹

51959

w¹¹¹⁸; P{nSyb-QF2.P}attP2, P{QUAS-nuclacZ.P}44/TM6B, Tb¹

61675

w^*; P{nSyb-MKII::nlsLexADBDo}attP24/CyO; P{QUAS(FRT.stop)p65AD::CaM}6, P{nSyb-QF2.P}attP2

61671

w^*; P{nSyb-MKII::GAL4DBDo}attP24, P{QUAS-p65AD::CaM}2, P{UAS-mCD8::GFP.L}LL5/CyO; P{nSyb-QF2.P}attP2, P{tub-QS.P}heph^9B

61673

w^*; P{nSyb-MKIIK11A::GAL4DBDo}attP24, P{QUAS-p65AD::CaM}2, P{UAS-mCD8::GFP.L}LL5/CyO; P{nSyb-QF2.P}attP2, P{tub-QS.P}heph^9B

64348

w^*; P{nSyb-MKII::nlsLexADBDo}attP24, P{QUAS-p65AD::CaM}2, P{13XLexAop2-mCD8::GFP}attP40/CyO; P{nSyb-QF2.P}attP2, P{tub-QS.P}heph^9B

61670

w^* P{10XUAS-IVS-mCD8::RFP}attP18 P{13XLexAop2-mCD8::GFP}su(Hw)attP8; P{nSyb-MKII::GAL4DBDo}attP24, P{QUAS-p65AD::CaM}2/CyO; P{nSyb-QF2.P}attP2 P{tub-QS.P}heph^9B

61672

w^* P{10XUAS-IVS-mCD8::RFP}attP18 P{13XLexAop2-mCD8::GFP}su(Hw)attP8; P{nSyb-MKIIK11A::GAL4DBDo}attP24, P{QUAS-p65AD::CaM}2/CyO; P{nSyb-QF2.P}attP2, P{tub-QS.P}heph^9B

64347

w^* P{10XUAS-IVS-mCD8::RFP}attP18 P{13XLexAop2-mCD8::GFP}su(Hw)attP8; P{nSyb-MKII::nlsLexADBDo}attP24, P{QUAS-p65AD::CaM}2/CyO; P{nSyb-QF2.P}attP2, P{tub-QS.P}heph^9B/TM6B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Ncra\QF^QF2.n-syb

Ncra\QF^QF2.nSyb

Syb-QF2

(Parkhitko et al., 2020)

n-syb-QF2

(Shearin et al., 2014)

Name Synonyms

Secondary FlyBase IDs

References (21)

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