FB2025_01 , released February 20, 2025
Allele: Dmel\Vps22
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General Information
Symbol
Dmel\Vps22
Species
D. melanogaster
Name
FlyBase ID
FBal0288716
Feature type
allele
Associated gene
Dmel\Vps2
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
Delta2-3 transposase
(Aoyama et al., 2013)
Progenitor genotype
P{GSV6}Vps2GS11024
(Aoyama et al., 2013)
Cytology
Description

Deletion of a 1187-bp genomic region, from 64-bp upstream of the initiation codon to 292-bp downstream of the vps2 stop codon. A relic P-element sequence derived from P{GSV6} is found next to the deleted region.

(Aoyama et al., 2013)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3R:26,052,853..26,054,039 [+]
Comment:

1187 bp deletion resulting from the imprecise excision of P{GSV6}Vps2GS11024, which deletes sequences from 64 bases upstream of the Vps2 translation initiation codon to 292 bp downstream of the termination codon. A relic P element sequence (CATGATGAAATAAGTATACTTG) from P{GSV6} is found next to the deleted region.

(Aoyama et al., 2013)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous vps22 cells fail to form large somatic clones in wing imaginal discs in a wild-type genetic background. However, large clones can be induced in a minute (heterozygous RpS3Plac92) genetic background. When clones induced in a minute background, a marked overproliferation of cells the wing imaginal discs is observed. The wing discs frequently fuse with haltere and leg discs. Even in wing discs that maintain a normal size, the epithelial structure appear disorganised. The apico-basal polarity of the cortical actin distribution appear disrupted in these cells. Compared with wild-type cells, the position of the nuclei along the apico-basal axis of the mutant cells is disorganised. The nuclei are occasionally fragmented, suggesting that apoptosis is induced.

      (Aoyama et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Not rescued by

      Vps22 is not rescued by Vps2UAS.cAa/Scer\GAL4Act5C.PI

      (Aoyama et al., 2013)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Vps22
      vps22
      (Aoyama et al., 2013)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)