Q142term | cpx-PA; Q125term | cpx-PAA; Q139term | cpx-PC; Q142term | cpx-PG; Q142term | cpx-PH; Q142term | cpx-PI; Q83term | cpx-PJ; Q83term | cpx-PK; Q128term | cpx-PL; Q139term | cpx-PM; Q139term | cpx-PO; Q139term | cpx-PP; Q146term | cpx-PS; Q143term | cpx-PU; Q142term | cpx-PV; Q139term | cpx-PW; Q142term | cpx-PX; Q143term | cpx-PY
Nonsense mutation in the last codon of most cpx isoforms. This removes the last residue, which is a Q in the C-terminal CaaX motif, thought to be necessary for farnesylation and implicated in membrane targeting in certain mammalian isoforms. Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.
Nonsense mutation that removes the last C-terminal amino acid (a Q in the X position of the C-terminal CaaX sequence) encoded by an alternative exon (location 3R:123210..124307 , release 5 genome) that is present in most isoforms including cpx-RU (the exon is not present in the cpx-RE isoform).
Amino acid replacement: Q143term.
brpnude/brp69; cpx1257/cpxSH1 double mutants have suppression of the increased eEPSC amplitude and mini frequency of cpx1257/cpxSH1 mutant larval muscle 6 and enhancement of the paired-pulse depression seen in both brpnude/brp69 mutants and cpx1257/cpxSH1 mutants.