FB2025_01 , released February 20, 2025
Allele: Dmel\ctaQ303L.UAS
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General Information
Symbol
Dmel\ctaQ303L.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0290962
Feature type
allele
Associated gene
Dmel\cta
Associated Insertion(s)
Carried in Construct
P{UAS-cta.Q303L}
Also Known As
UASt-CtaQ303L
Key Links
Transgenic product class
missense_variant
(Fuse et al., 2013)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Fuse et al., 2013)
Mutagen
in vitro construct
(Fuse et al., 2013)
Progenitor genotype
ctaUAS.cFa
(Fuse et al., 2013)
Carried in construct
P{UAS-cta.Q303L}
Cytology
Description

UAS regulatory sequences drive expression of the cta coding region into which a Q303L mutation has been introduced.

(Fuse et al., 2013)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
cta
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of ctaQ303L.Scer\UAS under the control of Scer\GAL4mat.αTub67C.T:Hsim\VP16 results in severe malformation of the embryo. Myosin accumulates in the lateral cell cortex and the epithelial architecture seems to have collapsed.

      (Fuse et al., 2013)

      Animals expressing ctaQ303L.Scer\UAS under the control of Scer\GAL4Mhc.PU exhibit small mitochondria that are spherical or elliptical in shape, indicating fragmentation. This effect is observed in animals raised at both 25[o]C and 28[o]C.

      (Ratnaparkhi, 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      NOT suppressed by
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of Gprk2Scer\UAS.cFa does not suppress the embryonic defects seen when ctaQ303L.Scer\UAS is expressed under the control of Scer\GAL4mat.αTub67C.T:Hsim\VP16.

      (Fuse et al., 2013)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      ctaQ303L.Scer\UAS
      ctaQ303L.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (5)