FB2025_01 , released February 20, 2025
Allele: Dmel\gwlNLSmut.UASp.Tag:MYC
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General Information
Symbol
Dmel\gwlNLSmut.UASp.Tag:MYC
Species
D. melanogaster
Name
FlyBase ID
FBal0291506
Feature type
allele
Associated gene
Dmel\gwl
Associated Insertion(s)
Carried in Construct
P{UASp-gwl.NLSmut.MYC}
Key Links
Transgenic product class
missense_variant
(Wang et al., 2013)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Wang et al., 2013)
Mutagen
in vitro construct
(Wang et al., 2013)
Progenitor genotype
Carried in construct
P{UASp-gwl.NLSmut.MYC}
Cytology
Description

UASp regulates expression of Tag:MYC-tagged gwl with mutations in both its two nuclear localization (NLS) motifs (K518M and K520M in NLS1, and K564M and R566L in NSL2).

(Wang et al., 2013)
Allele components
Component
Use(s)
Regulatory region(s)
UASp
Encoded product / tool
gwl
Tagged with
Tag:MYC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Scer\GAL4Act.PU-mediated expression of gwlNLSmut.Scer\UAS.P\T.T:Hsap\MYC in a gwlSr3/gwlSr6 mutants background results in viable but female sterile flies. Ovaries are completely lacking.

      (Wang et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      gwlNLSmut.UASp.Tag:MYC/Scer\GAL4Act.PU partially rescues gwlSr6/gwlSr3

      (Wang et al., 2013)
      Fails to rescue

      gwlNLSmut.UASp.Tag:MYC/Scer\GAL4VP16.mat.αTub67C fails to rescue gwl6a/gwlSr18

      (Wang et al., 2013)
      Comments

      Scer\GAL4Act.PU-mediated expression of gwlNLSmut.Scer\UAS.P\T.T:Hsap\MYC incompletely rescues the lethality of gwlSr3/gwlSr6 mutants.

      Scer\GAL4mat.αTub67C.T:Hsim\VP16-mediated expression of gwlNLSmut.Scer\UAS.P\T.T:Hsap\MYC fails to rescue the female sterility of gwl6a/gwlSr18 mutants.

      (Wang et al., 2013)
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      gwlNLSmut.Scer\UAS.P\T.T:Hsap\MYC
      gwlNLSmut.UASp.Tag:MYC
      Name Synonyms
      Secondary FlyBase IDs
        References (1)