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General Information
Symbol
Dmel\AblN.UAS.GFP
Species
D. melanogaster
Name
FlyBase ID
FBal0291740
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

A 10xUAS cassette is used to drive expression of amino acid residues 1-644 of Abl which are tagged at the C-terminal end with GFP.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of AblN.Scer\UAS.T:Avic\GFP under the control of Scer\GAL4eg-Mz360 does not appear to affect nervous system development.

Expression of AblN.Scer\UAS.T:Avic\GFP in the EW neurons of Abl2 mutant embryos results in a dramatic increase in the number of commissural defects.

Pan-neural expression of AblN.Scer\UAS.T:Avic\GFP under the control of Scer\GAL4elav.PLu results in a partially penetrant bypass phenotype. This bypass phenotype occurs when ISNb axons fail to defasciculate, and instead continue to grow dorsally past their muscle targets.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement
Reference
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

Expression of AblN.Scer\UAS.T:Avic\GFP in ap neurons, under the control of Scer\GAL4ap-md544 enhances the axon crossing defects found in sli2/+ mutant embryos, indicating the C-terminal portion of Abl is not involved in this interaction.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

Expression of AblN.Scer\UAS.T:Avic\GFP in the EW neurons of Abl2 mutant embryos results in a dramatic increase in the number of commissural defects.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
AblN.Scer\UAS.T:Avic\GFP
AblN.UAS.GFP
Name Synonyms
Secondary FlyBase IDs
    References (1)