FB2025_01 , released February 20, 2025
Allele: Dmel\Bcs1HMC03437
Open Close
General Information
Symbol
Dmel\Bcs1HMC03437
Species
D. melanogaster
Name
FlyBase ID
FBal0292586
Feature type
allele
Associated gene
Dmel\Bcs1
Associated Insertion(s)
Carried in Construct
P{TRiP.HMC03437}
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Ni et al., 2010.12.1)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Ni et al., 2010.12.1)
Mutagen
in vitro construct
(Ni et al., 2010.12.1)
Progenitor genotype
Carried in construct
P{TRiP.HMC03437}
Cytology
Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
dsRNA-HMC03437
Also carries
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expressing Bcs1HMC03437 under the control of Scer\GAL4Act5C.PI results in locomotor defects in third instar larvae, including lower motility and dramatically decreased peristaltic movements.

      Expressing Bcs1HMC03437 under the control of Scer\GAL4elav-C155 leads to adults that are unable to stand or walk and display paralysis, with seizures and dystonic movements.

      Expressing Bcs1HMC03437 under the control of Scer\GAL4ple.PU leads to a progressive decrease in adult climbing activity.

      (Brischigliaro et al., 2021)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Bcs1HMC03437
      CG4908HMC03437
      Name Synonyms
      Secondary FlyBase IDs
        References (3)