FlyBase Allele Report: Dmel\Coq2[HMC03492]

General Information

Symbol

Dmel\Coq2^HMC03492

Species

D. melanogaster

Name

FlyBase ID

FBal0292640

Feature type

allele

Associated gene

Dmel\Coq2

Associated Insertion(s)

Carried in Construct

P{TRiP.HMC03492}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

(Ni et al., 2010.12.1)

Progenitor genotype

Carried in construct

P{TRiP.HMC03492}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMC03492

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of primary coenzyme Q10 deficiency 1

CEC

(Zhu et al., 2017)

model of nephrotic syndrome

CEA

(Zhu et al., 2017)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of primary coenzyme Q10 deficiency 1

is exacerbated by Atg1^JF02273

(Zhu et al., 2017)

is exacerbated by Atg6^JF02897

(Zhu et al., 2017)

is ameliorated by Hsap\COQ2^WT.UAS

(Zhu et al., 2017)

model of nephrotic syndrome

is exacerbated by Atg1^JF02273

(Zhu et al., 2017)

is exacerbated by Atg6^JF02897

(Zhu et al., 2017)

is ameliorated by Hsap\COQ2^WT.UAS

(Zhu et al., 2017)

Comments on Models/Modifiers Based on Experimental Evidence ( 1 )

FlyBase curator comment: 'coenzyme Q10 deficiency disease' subtype 'primary coenzyme Q10 deficiency 1' is associated with gene COQ2. Coq2^HMC03492, when driven in pericardial nephrocytes (Scer\GAL4^Ugt36A1.PK) serves to model the nephrotic syndrome phenotype of 'primary coenzyme Q10 deficiency 1'.

(Zhu et al., 2017)

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

short lived, with Scer\GAL4^Ugt36A1.PK

(Fu et al., 2017)

visible | adult stage, with Scer\GAL4^eya.enh1+E+2

(Pletcher et al., 2019)

Phenotype Manifest In

adult pericardial cell, with Scer\GAL4^Ugt36A1.PK

(Fu et al., 2017)

eye, with Scer\GAL4^eya.enh1+E+2

(Pletcher et al., 2019)

nephrocyte, with Scer\GAL4^Ugt36A1.PK

(Zhu et al., 2017)

Detailed Description

Statement

Reference

Expression under the control of Scer\GAL4^eya.enh1+E+2 results in a glossy eye phenotype.

(Pletcher et al., 2019)

Adult flies expressing Coq2^HMC03492 under the control of Scer\GAL4^Dot.PK display nephrocyte functional defects (measured by uptake assays) and reduced adult lifespan relative to controls.

(Fu et al., 2017)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

53276

y¹ v¹; P{TRiP.HMC03492}attP40

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Coq2^HMC03492

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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