FlyBase Allele Report: Dmel\AGO1[HMC03509]

General Information

Symbol

Dmel\AGO1^HMC03509

Species

D. melanogaster

Name

FlyBase ID

FBal0292657

Feature type

allele

Associated gene

Dmel\AGO1

Associated Insertion(s)

Carried in Construct

P{TRiP.HMC03509}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

(Ni et al., 2010.12.1)

Progenitor genotype

Carried in construct

P{TRiP.HMC03509}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMC03509

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy, with Scer\GAL4^21-7

(Lee et al., 2015)

decreased cell number | adult stage | conditional, with Scer\GAL4^NP6267

(Takemura et al., 2021)

decreased occurrence of cell division | adult stage | conditional, with Scer\GAL4^NP6267

(Takemura et al., 2021)

Phenotype Manifest In

adult midgut | conditional, with Scer\GAL4^NP6267

(Takemura et al., 2021)

adult midgut epithelial cell | decreased number | conditional, with Scer\GAL4^NP6267

(Takemura et al., 2021)

dendrite, with Scer\GAL4^21-7

(Lee et al., 2015)

larval multidendritic class IV neuron, with Scer\GAL4^21-7

(Lee et al., 2015)

Detailed Description

Statement

Reference

Individuals expressing AGO1^HMC03509 under the control of Scer\GAL4^NP6267, induced one day prior to infection with Pseudomonas entomophila, show a significantly smaller increase in midgut mitosis at day 0; there is also a decrease in the number of AGO1^HMC03509-expressing cells in the midgut.

(Takemura et al., 2021)

Expression of AGO1^HMC03509 under the control of Scer\GAL4^21-7 results in class IV dendritic arborizing neurons that exhibit a reduction in mean terminal dendrite length. Frequency of dendrite-dendrite crossing over is similar to controls.

(Lee et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

AGO1^HMC03509, Scer\GAL4^21-7 has abnormal neuroanatomy phenotype, non-enhanceable by trc^KK109419, Scer\GAL4^21-7

(Lee et al., 2015)

NOT Enhancer of

Statement

Reference

AGO1^HMC03509, Scer\GAL4^21-7 is a non-enhancer of abnormal neuroanatomy phenotype of Scer\GAL4^21-7, trc^KK109419

(Lee et al., 2015)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

AGO1^HMC03509, Scer\GAL4^21-7 has larval multidendritic class IV neuron phenotype, non-enhanceable by trc^KK109419, Scer\GAL4^21-7

(Lee et al., 2015)

AGO1^HMC03509, Scer\GAL4^21-7 has dendrite phenotype, non-enhanceable by trc^KK109419, Scer\GAL4^21-7

(Lee et al., 2015)

NOT Enhancer of

Statement

Reference

AGO1^HMC03509, Scer\GAL4^21-7 is a non-enhancer of larval multidendritic class IV neuron phenotype of Scer\GAL4^21-7, trc^KK109419

(Lee et al., 2015)

AGO1^HMC03509, Scer\GAL4^21-7 is a non-enhancer of dendrite phenotype of Scer\GAL4^21-7, trc^KK109419

(Lee et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of AGO1^HMC03509 and AGO1^HMC03509 under the control of Scer\GAL4^21-7 results in increased frequency of dendrite-dendrite crossing over in class IV dendritic arborizing neurons compared to controls (as is seen with trc^KK109419 alone) and a decrease in mean terminal dendrite length (as is seen with trc^KK109419 alone).

(Lee et al., 2015)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

53293

y¹ sc^* v¹ sev²¹; P{TRiP.HMC03509}attP40

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

AGO1^HMC03509

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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