FlyBase Allele Report: Dmel\Tsc1[HMC03672]

General Information

Symbol

Dmel\Tsc1^HMC03672

Species

D. melanogaster

Name

FlyBase ID

FBal0292805

Feature type

allele

Associated gene

Dmel\Tsc1

Associated Insertion(s)

Carried in Construct

P{TRiP.HMC03672}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

(Ni et al., 2010.12.1)

Progenitor genotype

Carried in construct

P{TRiP.HMC03672}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMC03672

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

enteroendocrine cell | P-stage | increased number, with Scer\GAL4^Mef2.247

(Zhang et al., 2024)

enteroendocrine cell | P-stage | increased number, with Scer\GAL4^phtm.PO, Scer\GAL80^spok.1.45

(Zhang et al., 2024)

eye, with Scer\GAL4^eya.enh1+E+2

(Pletcher et al., 2019)

fat cell | third instar larval stage, with Scer\GAL4^AB1

(Sharma et al., 2019)

muscle system | P-stage, with Scer\GAL4^Mef2.247

(Zhang et al., 2024)

Detailed Description

Statement

Reference

Expression under the control of Scer\GAL4^eya.enh1+E+2 results in a large eye phenotype.

(Pletcher et al., 2019)

Third instar larvae expressing Tsc1^HMC03672 under the control of Scer\GAL4^AB1 show significantly bigger salivary gland cells, as compared to controls.

(Sharma et al., 2019)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT suppressed by

Statement

Reference

Scer\GAL4^AB1, Tsc1^HMC03672 has increased cell size | third instar larval stage phenotype, non-suppressible by PIP4K²⁹

(Sharma et al., 2019)

Phenotype Manifest In

NOT suppressed by

Statement

Reference

Scer\GAL4^AB1, Tsc1^HMC03672 has fat cell | third instar larval stage phenotype, non-suppressible by PIP4K²⁹

(Sharma et al., 2019)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

52931

y¹ sc^* v¹ sev²¹; P{TRiP.HMC03672}attP40

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Tsc1^HMC03672

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections

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