FlyBase Allele Report: Dmel\dome[HMJ21208]

FB2025_05 , released December 11, 2025

FB2025_05 , released December 11, 2025

Allele: Dmel\dome^HMJ21208

General Information

Symbol

Dmel\dome^HMJ21208

Species

D. melanogaster

Name

FlyBase ID

FBal0293026

Feature type

allele

Associated gene

Associated Insertion(s)

Carried in Construct

P{TRiP.HMJ21208}

Key Links

Genomic Maps

Transgenic product class

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

(Ni et al., 2010.12.1)

Progenitor genotype

Carried in construct

P{TRiP.HMJ21208}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)

Allele components

Component

Use(s)

Regulatory region(s)

binary expression system - regulatory region

Encoded product / tool

Also carries

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Alexander disease

modeled by Hsap\GFAP^R79H.QUAS

(Wang et al., 2022)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased size | adult stage | somatic clone, with Scer\GAL4^R42A07.-FRT

(Harris et al., 2020)

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

dome^HMJ21208/Scer\GAL4^R42A07.-FRT is an enhancer of visible | adult stage | somatic clone phenotype of Ecol\lexA^DBD.R85E08, Hsap\RELA^AD.Hsp70, rpr^{13xlexAop.cHa}

(Harris et al., 2020)

dome^HMJ21208/Scer\GAL4^R42A07.-FRT is an enhancer of decreased size | adult stage | somatic clone phenotype of Ecol\lexA^DBD.R85E08, Hsap\RELA^AD.Hsp70, rpr^{13xlexAop.cHa}

(Harris et al., 2020)

Phenotype Manifest In

Enhancer of

Statement

Reference

dome^HMJ21208/Scer\GAL4^R42A07.-FRT is an enhancer of wing | somatic clone phenotype of Ecol\lexA^DBD.R85E08, Hsap\RELA^AD.Hsp70, rpr^{13xlexAop.cHa}

(Harris et al., 2020)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

53890

y¹ v¹; P{TRiP.HMJ21208}attP40

HMJ21208

y¹ v¹; P{TRiP.HMJ21208}attP40/CyO

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

dome^BL53890

(Liu et al., 2015)

dome^HMJ21208

dome^RNAi

(Bhaskar et al., 2022)

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections