FlyBase Allele Report: Dmel\Tsc1[HMJ21477]

General Information

Symbol

Dmel\Tsc1^HMJ21477

Species

D. melanogaster

Name

FlyBase ID

FBal0293193

Feature type

allele

Associated gene

Dmel\Tsc1

Associated Insertion(s)

Carried in Construct

P{TRiP.HMJ21477}

Also Known As

UAS-Tsc1-RNAi, UAS-Tsc1 RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

(Ni et al., 2010.12.1)

Progenitor genotype

Carried in construct

P{TRiP.HMJ21477}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMJ21477

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cell cycle | oogenesis, with Scer\GAL4^nanos.PG

(Taslim et al., 2023)

abnormal size | adult stage, with Scer\GAL4^eya.enh1+E+2

(Pletcher et al., 2019)

abnormal stress response | oogenesis, with Scer\GAL4^nanos.PG

(Taslim et al., 2023)

increased size | third instar larval stage, with Scer\GAL4^en.PU

(Yuen et al., 2021)

Phenotype Manifest In

eye, with Scer\GAL4^eya.enh1+E+2

(Pletcher et al., 2019)

female germline stem cell, with Scer\GAL4^nanos.PG

(Taslim et al., 2023)

mitochondrion | oogenesis, with Scer\GAL4^nanos.PG

(Taslim et al., 2023)

wing disc posterior compartment | third instar larval stage, with Scer\GAL4^en.PU

(Yuen et al., 2021)

Detailed Description

Statement

Reference

The expression of Tsc1^HMJ21477 under the control of Scer\GAL4^en.PU results in increased growth of the posterior compartment, seen by a decreased density of cell nuclei.

(Yuen et al., 2021)

Expression under the control of Scer\GAL4^eya.enh1+E+2 results in a large eye phenotype.

(Pletcher et al., 2019)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

The co-expression of Tsc1^HMJ21477 and pnut^GD1512 from the second instar larval stage under the combined control of Scer\GAL4^ap-md544 and Gal80[ts] does not leads to the formation of tumors in the third instar larval wing disc.

(Gerlach et al., 2018)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

54034