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General Information
Symbol
Zzzz\CAG55.UAS.Tag:MYC,Tag:FLAG
Species
a. artificial
Name
FlyBase ID
FBal0293651
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UAS regulatory sequences drive expression of a Zzzz\CAG-repeat encoding 55 glutamines. The repeats are flanked by six amino acids on the N-terminal side and four on the C-terminal, and the Tag:MYC and Tag:FLAG epitope tags are located downstream.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of one copy of Zzzz\CAG55.Scer\UAS.T:Hsap\MYC,T:Zzzz\FLAG under the control of Scer\GAL4GMR.PFa results in mild eye pigmentation loss, localised mainly to the posterior of the eye. Very few photoreceptors are evident in the ommatidium. The phenotype is more severe when two copies of the transgene are expressed.

Flies expressing Zzzz\CAG55.Scer\UAS.T:Hsap\MYC,T:Zzzz\FLAG under the control of Scer\GAL4da.G32 are lethal prior to pupariation. Aggregates are seen in third instar larvae and these are predominantly nuclear.

Brains from adult flies expressing Zzzz\CAG55.Scer\UAS.T:Hsap\MYC,T:Zzzz\FLAG under the control of Scer\GAL4elav.PLu exhibit a large number of aggregates that are localised to the neuronal cell body. They are found in the central brain, the optic lobes nd the antennae. A single aggregate is seen per nucleus.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Zzzz\CAG55.Scer\UAS.T:Hsap\MYC,T:Zzzz\FLAG
Zzzz\CAG55.UAS.Tag:MYC,Tag:FLAG
Name Synonyms
Secondary FlyBase IDs
    References (1)