FlyBase Allele Report: Mmus\Gria1[Lc.UAS]

General Information

Symbol

Mmus\Gria1^Lc.UAS

Species

M. musculus

Name

FlyBase ID

FBal0293685

Feature type

allele

Associated gene

Mmus\Gria1

Associated Insertion(s)

Carried in Construct

P{UAS-mGria1.Lc}

Also Known As

UAS-GluR1^Lc

Transgenic product class

missense_variant

(Yang et al., 2013)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

missense_variant

(Yang et al., 2013)

Mutagen

in vitro construct

(Yang et al., 2013)

Progenitor genotype

Carried in construct

P{UAS-mGria1.Lc}

Cytology

Description

UASt regulatory sequences drive expression of a 'Lurcher' mutant fragment of Mmus\Gria1.

(Yang et al., 2013)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Mmus\Gria1

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of brain ischemia

CEA

(Lei et al., 2017)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of brain ischemia

is ameliorated by Hsp26^UAS.cUa

(Lei et al., 2017)

is ameliorated by Hsp27^UAS.cUa

(Lei et al., 2017)

is ameliorated by PPP1R15^e02638

(Lei et al., 2017)

is ameliorated by SerRS^KG03126

(Lei et al., 2017)

is ameliorated by SerRS^RNAi.UAS

(Lei et al., 2017)

is ameliorated by p53^11-1B-1

(Lei et al., 2017)

is exacerbated by p53^UAS.cUa

(Lei et al., 2017)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

increased cell death, with Scer\GAL4^hs.2sev

(Yang et al., 2013)

Phenotype Manifest In

eye, with Scer\GAL4^hs.2sev

(Yang et al., 2013)

interommatidial bristle, with Scer\GAL4^hs.2sev

(Yang et al., 2013)

ommatidium, with Scer\GAL4^hs.2sev

(Yang et al., 2013)

photoreceptor neuron, with Scer\GAL4^hs.2sev

(Yang et al., 2013)

Detailed Description

Statement

Reference

Expression of Mmus\Gria1^Lc.Scer\UAS in the developing eye, under the control of Scer\GAL4^hs.2sev results in a reduction in adult eye size, with a concomitant reduction in the number of ommatidia and interommatidial bristles. Eye cells appear damaged, with a loss of plasma membrane integrity and the emergence of intra-cellular vacuoles. Cellular appearance suggests massive cell death in neuronal and non-neuronal cells in the adult eyes. Mmus\Gria1^Lc.Scer\UAS-expressing neurons display positive staining for the necrotic marker propidium iodide, along with other feautres of necrosis, such as mitochondrial defects, elevation of ROS level and an increase in cytoplasmic acidification. Newly-formed ommatidia in the anterior region of Scer\GAL4^hs.2sev>Mmus\Gria1^Lc.Scer\UAS eye discs are relatively normal. However, in the posterior region, the elav staining is diminished in Mmus\Gria1-positive R3/R4 cells and becomes clumpy in the adjacent neurons, indicating spreading death in adjacent neurons at the larval stage.

(Yang et al., 2013)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

BacA\p35^GMR.PH, Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has increased cell death phenotype, enhanceable by bsk¹/BacA\p35^GMR.PH/bsk[+]

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has increased cell death phenotype, enhanceable by Marf^JF01650, Scer\GAL4^hs.2sev

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has increased cell death phenotype, enhanceable by Opa1^HMS00349, Scer\GAL4^hs.2sev

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has increased cell death phenotype, enhanceable by whd^HMS00033, Scer\GAL4^hs.2sev

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has increased cell death phenotype, enhanceable by wal^HMS01263, Scer\GAL4^hs.2sev

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has increased cell death phenotype, enhanceable by Df(3R)ED6346

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has increased cell death phenotype, enhanceable by Df(2L)ED206

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has increased cell death phenotype, enhanceable by Df(2R)ED1791

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has increased cell death phenotype, enhanceable by Df(3L)ED228

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has increased cell death phenotype, enhanceable by Df(2L)ED1226

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has increased cell death phenotype, enhanceable by Df(3R)ED6027

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has increased cell death phenotype, enhanceable by emb^EY08770, Scer\GAL4^hs.2sev

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has increased cell death phenotype, enhanceable by egr^UAS.cIa, Scer\GAL4^hs.2sev

(Yang et al., 2013)

BacA\p35^GMR.PH, Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has increased cell death phenotype, enhanceable by BacA\p35^GMR.PH/puc^E69/puc[+]

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has increased cell death phenotype, enhanceable by puc^E69/puc[+]

(Yang et al., 2013)

NOT Enhanced by

Statement

Reference

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has increased cell death phenotype, non-enhanceable by Diap2^UAS.cLa, Scer\GAL4^hs.2sev

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has increased cell death phenotype, non-enhanceable by Diap1^UAS.cUa, Scer\GAL4^hs.2sev

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has increased cell death phenotype, non-enhanceable by bsk^DN.UAS, Scer\GAL4^hs.2sev

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has increased cell death phenotype, non-enhanceable by hep^RNAi.UAS.cUa, Scer\GAL4^hs.2sev

(Yang et al., 2013)

Suppressed by

Statement

Reference

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has increased cell death phenotype, suppressible by Cyt-c-d^bln1/Cyt-c-d[+]

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has increased cell death phenotype, suppressible by wal[+]/wal⁰²⁵¹⁶

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has increased cell death phenotype, suppressible by BacA\p35^GMR.PH/wal[+]/wal⁰²⁵¹⁶

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has increased cell death phenotype, suppressible by Df(3L)vin5/BacA\p35^GMR.PH

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has increased cell death phenotype, suppressible by BacA\p35^GMR.PH/Df(2L)cact-255rv64

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has increased cell death phenotype, suppressible by BacA\p35^GMR.PH/Cyt-c-d^bln1/Cyt-c-d[+]

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has increased cell death phenotype, suppressible by BacA\p35^GMR.PH

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has increased cell death phenotype, suppressible by Drice^Δ1/Dcp-1[+]/Dcp-1^Prev1

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has increased cell death phenotype, suppressible by Df(3L)H99

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has increased cell death phenotype, suppressible by W[+]/hid^rvE1

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has increased cell death phenotype, suppressible by hid^rvE1/Df(3L)H99

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has increased cell death phenotype, suppressible by hep¹

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has increased cell death phenotype, suppressible by hep[+]/hep^r75

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has increased cell death phenotype, suppressible by bsk¹/bsk[+]

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has increased cell death phenotype, suppressible by bsk¹/hep^r75

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has increased cell death phenotype, suppressible by Traf6[+]/Traf6^ex1

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has increased cell death phenotype, suppressible by Df(3L)ED224

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has increased cell death phenotype, suppressible by Df(3L)ED225

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has increased cell death phenotype, suppressible by Df(1)C246

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has increased cell death phenotype, suppressible by Df(2L)cact-255rv64

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has increased cell death phenotype, suppressible by Df(3L)vin5

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has increased cell death phenotype, suppressible by Df(2L)BSC5

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has increased cell death phenotype, suppressible by Df(3R)L127

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has increased cell death phenotype, suppressible by Df(3L)ED4408

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has increased cell death phenotype, suppressible by mbc^EY01437, Scer\GAL4^hs.2sev

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has increased cell death phenotype, suppressible by Rok^HMS01311, Scer\GAL4^hs.2sev

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has increased cell death phenotype, suppressible by Rho1^HMS00375, Scer\GAL4^hs.2sev

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has increased cell death phenotype, suppressible by sqh^HMS00830, Scer\GAL4^hs.2sev

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has increased cell death phenotype, suppressible by Df(2L)ED1454

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has increased cell death phenotype, suppressible by Df(3L)ED208

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has increased cell death phenotype, suppressible by RanBP3^EY10605, Scer\GAL4^hs.2sev

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has increased cell death phenotype, suppressible by emb^HMS00991, Scer\GAL4^hs.2sev

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has increased cell death phenotype, suppressible by lbm^EY02692, Scer\GAL4^hs.2sev

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has increased cell death phenotype, suppressible by Nsf2^HMS01262, Scer\GAL4^hs.2sev

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has increased cell death phenotype, suppressible by Wnt2^HMS01613, Scer\GAL4^hs.2sev

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has increased cell death phenotype, suppressible by Df(3L)ED4606

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has increased cell death phenotype, suppressible by Df(3L)ED4457

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has increased cell death phenotype, suppressible by Df(3R)ED10642

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has increased cell death phenotype, suppressible by Df(3L)ED4486

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has increased cell death phenotype, suppressible by Df(2R)ED2436

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has increased cell death phenotype, suppressible by Df(3L)Exel9003

(Yang et al., 2013)

NOT suppressed by

Statement

Reference

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has increased cell death phenotype, non-suppressible by Diap1^UAS.cUa, Scer\GAL4^hs.2sev

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has increased cell death phenotype, non-suppressible by rpr[+]/rpr⁸⁷

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has increased cell death phenotype, non-suppressible by bsk^DN.UAS, Scer\GAL4^hs.2sev

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has increased cell death phenotype, non-suppressible by hep^RNAi.UAS.cUa, Scer\GAL4^hs.2sev

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has increased cell death phenotype, non-suppressible by Cat^UAS.cAa, Scer\GAL4^hs.2sev

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has increased cell death phenotype, non-suppressible by Cat^UAS.cAa/Gtpx^UAS.cMa, Scer\GAL4^hs.2sev

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has increased cell death phenotype, non-suppressible by BacA\p35^GMR.PH/Marf^JF01650, Scer\GAL4^hs.2sev

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has increased cell death phenotype, non-suppressible by BacA\p35^GMR.PH/wal^HMS01263, Scer\GAL4^hs.2sev

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has increased cell death phenotype, non-suppressible by BacA\p35^GMR.PH/egr^RNAi.UAS, Scer\GAL4^hs.2sev

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has increased cell death phenotype, non-suppressible by AIF^T52

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has increased cell death phenotype, non-suppressible by Diap2^UAS.cLa, Scer\GAL4^hs.2sev

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has increased cell death phenotype, non-suppressible by BacA\p35^UAS.cUa, Scer\GAL4^hs.2sev

(Yang et al., 2013)

Phenotype Manifest In

Enhanced by

Statement

Reference

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has eye phenotype, enhanceable by Marf^JF01650, Scer\GAL4^hs.2sev

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has eye phenotype, enhanceable by Opa1^HMS00349, Scer\GAL4^hs.2sev

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has eye phenotype, enhanceable by whd^HMS00033, Scer\GAL4^hs.2sev

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has eye phenotype, enhanceable by wal^HMS01263, Scer\GAL4^hs.2sev

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has eye phenotype, enhanceable by Df(3R)ED6346

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has eye phenotype, enhanceable by BacA\p35^GMR.PH

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has eye phenotype, enhanceable by Df(2L)ED206

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has eye phenotype, enhanceable by Df(2R)ED1791

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has eye phenotype, enhanceable by Df(3L)ED228

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has eye phenotype, enhanceable by Df(2L)ED1226

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has eye phenotype, enhanceable by Df(3R)ED6027

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has eye phenotype, enhanceable by puc^E69/puc[+]

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has eye phenotype, enhanceable by emb^EY08770, Scer\GAL4^hs.2sev

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has eye phenotype, enhanceable by egr^UAS.cIa, Scer\GAL4^hs.2sev

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has eye phenotype, enhanceable by bsk¹/bsk[+], Scer\GAL4^hs.2sev

(Yang et al., 2013)

BacA\p35^GMR.PH, Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has eye phenotype, enhanceable by bsk¹/bsk[+], Scer\GAL4^hs.2sev

(Yang et al., 2013)

BacA\p35^GMR.PH, Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has eye phenotype, enhanceable by BacA\p35^GMR.PH/puc^E69/puc[+], Scer\GAL4^hs.2sev

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has eye phenotype, enhanceable by BacA\p35^GMR.PH/puc^E69/puc[+], Scer\GAL4^hs.2sev

(Yang et al., 2013)

BacA\p35^GMR.PH, Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has eye phenotype, enhanceable by bsk¹/BacA\p35^GMR.PH/bsk[+]

(Yang et al., 2013)

NOT Enhanced by

Statement

Reference

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has eye phenotype, non-enhanceable by Diap2^UAS.cLa, Scer\GAL4^hs.2sev

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has eye phenotype, non-enhanceable by Diap1^UAS.cUa, Scer\GAL4^hs.2sev

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has eye phenotype, non-enhanceable by bsk^DN.UAS, Scer\GAL4^hs.2sev

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has eye phenotype, non-enhanceable by hep^RNAi.UAS.cUa, Scer\GAL4^hs.2sev

(Yang et al., 2013)

Suppressed by

Statement

Reference

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has eye phenotype, suppressible by BacA\p35^GMR.PH

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has eye phenotype, suppressible by Drice^Δ1/Dcp-1[+]/Dcp-1^Prev1

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has eye phenotype, suppressible by Df(3L)H99

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has eye phenotype, suppressible by W[+]/hid^rvE1

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has eye phenotype, suppressible by hid^rvE1/Df(3L)H99

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has eye phenotype, suppressible by hep¹

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has eye phenotype, suppressible by hep[+]/hep^r75

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has eye phenotype, suppressible by bsk¹/bsk[+]

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has eye phenotype, suppressible by bsk¹/hep^r75

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has eye phenotype, suppressible by Traf6[+]/Traf6^ex1

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has eye phenotype, suppressible by Cat^UAS.cAa, Scer\GAL4^hs.2sev

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has eye phenotype, suppressible by Cat^UAS.cAa/Gtpx^UAS.cMa, Scer\GAL4^hs.2sev

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has eye phenotype, suppressible by Df(3L)ED224

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has eye phenotype, suppressible by Df(3L)ED225

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has eye phenotype, suppressible by Df(1)C246

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has eye phenotype, suppressible by Df(2L)cact-255rv64

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has eye phenotype, suppressible by Df(3L)vin5

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has eye phenotype, suppressible by Df(2L)BSC5

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has eye phenotype, suppressible by Df(3R)L127

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has eye phenotype, suppressible by Df(3L)ED4408

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has eye phenotype, suppressible by mbc^EY01437, Scer\GAL4^hs.2sev

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has eye phenotype, suppressible by Rok^HMS01311, Scer\GAL4^hs.2sev

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has eye phenotype, suppressible by Rho1^HMS00375, Scer\GAL4^hs.2sev

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has eye phenotype, suppressible by sqh^HMS00830, Scer\GAL4^hs.2sev

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has eye phenotype, suppressible by Df(2L)ED1454

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has eye phenotype, suppressible by Df(3L)ED208

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has eye phenotype, suppressible by RanBP3^EY10605, Scer\GAL4^hs.2sev

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has eye phenotype, suppressible by emb^HMS00991, Scer\GAL4^hs.2sev

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has eye phenotype, suppressible by lbm^EY02692, Scer\GAL4^hs.2sev

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has eye phenotype, suppressible by Nsf2^HMS01262, Scer\GAL4^hs.2sev

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has eye phenotype, suppressible by Wnt2^HMS01613, Scer\GAL4^hs.2sev

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has eye phenotype, suppressible by Df(3L)ED4606

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has eye phenotype, suppressible by Df(3L)ED4457

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has eye phenotype, suppressible by Df(3L)ED4486

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has eye phenotype, suppressible by Df(3R)ED10642

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has eye phenotype, suppressible by Df(2R)ED2436

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has eye phenotype, suppressible by Df(3L)Exel9003

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has eye phenotype, suppressible by Cyt-c-d^bln1/Cyt-c-d[+]

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has eye phenotype, suppressible by wal[+]/wal⁰²⁵¹⁶, Scer\GAL4^hs.2sev

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has eye phenotype, suppressible by BacA\p35^GMR.PH/wal[+]/wal⁰²⁵¹⁶, Scer\GAL4^hs.2sev

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has eye phenotype, suppressible by Df(3L)vin5/BacA\p35^GMR.PH

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has eye phenotype, suppressible by BacA\p35^GMR.PH/Df(2L)cact-255rv64

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has eye phenotype, suppressible by BacA\p35^GMR.PH/Cyt-c-d^bln1/Cyt-c-d[+]

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has eye phenotype, suppressible by egr^RNAi.UAS, Scer\GAL4^hs.2sev

(Yang et al., 2013)

NOT suppressed by

Statement

Reference

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has eye phenotype, non-suppressible by Diap2^UAS.cLa, Scer\GAL4^hs.2sev

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has eye phenotype, non-suppressible by BacA\p35^UAS.cUa, Scer\GAL4^hs.2sev

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has eye phenotype, non-suppressible by AIF^T52

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has eye phenotype, non-suppressible by Diap1^UAS.cUa, Scer\GAL4^hs.2sev

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has eye phenotype, non-suppressible by rpr[+]/rpr⁸⁷

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has eye phenotype, non-suppressible by bsk^DN.UAS, Scer\GAL4^hs.2sev

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has eye phenotype, non-suppressible by hep^RNAi.UAS.cUa, Scer\GAL4^hs.2sev

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has eye phenotype, non-suppressible by BacA\p35^GMR.PH/Marf^JF01650, Scer\GAL4^hs.2sev

(Yang et al., 2013)

Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev has eye phenotype, non-suppressible by BacA\p35^GMR.PH/wal^HMS01263, Scer\GAL4^hs.2sev

(Yang et al., 2013)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Inhibition of apoptosis, through co-expression of Iap2^Scer\UAS.cLa, BacA\p35^Scer\UAS.cUa or th^Scer\UAS.cUa, does not affect the Mmus\Gria1^Lc.Scer\UAS eye defect (when all are expressed under the control of Scer\GAL4^hs.2sev.

A BacA\p35^GMR.PH background strongly rescues the adult eye size defect found upon expression of Mmus\Gria1^Lc.Scer\UAS under the control of Scer\GAL4^hs.2sev. Non-neuronal cells, but not R cells, are strongly rescued.

A Dcp-1^Prev1/+; Ice^Δ1/Ice^Δ1 background strongly suppresses the adult eye size defect found upon expression of Mmus\Gria1^Lc.Scer\UAS under the control of Scer\GAL4^hs.2sev.

A Df(3L)H99 background strongly suppresses the adult eye size defect found upon expression of Mmus\Gria1^Lc.Scer\UAS under the control of Scer\GAL4^hs.2sev.

A W^rvE1/+ or W^rvE1/Df(3L)H99 heterozygous background rescues the reduced adult eye size found upon expression of Mmus\Gria1^Lc.Scer\UAS under the control of Scer\GAL4^hs.2sev.

A rpr⁸⁷ heterozygous background does not rescue the reduced adult eye size found upon expression of Mmus\Gria1^Lc.Scer\UAS under the control of Scer\GAL4^hs.2sev.

A hep¹/Y background rescues the reduced adult eye size phenotype found in Scer\GAL4^hs.2sev->Mmus\Gria1^Lc.Scer\UAS flies.

A hep^r75/+ background rescues the reduced adult eye size phenotype found in Scer\GAL4^hs.2sev->Mmus\Gria1^Lc.Scer\UAS flies.

A bsk¹/+ background rescues the reduced adult eye size phenotype found in Scer\GAL4^hs.2sev->Mmus\Gria1^Lc.Scer\UAS flies.

A hep^r75 bsk¹ background rescues the reduced adult eye size phenotype found in Scer\GAL4^hs.2sev->Mmus\Gria1^Lc.Scer\UAS flies. Quantification of the ommatidia density suggests that ~47% of spreading apoptosis in R cells can be rescued by a hep^r75 bsk¹ double mutant background.

A Traf6^ex1/+ background rescues the reduced adult eye size phenotype found in Scer\GAL4^hs.2sev->Mmus\Gria1^Lc.Scer\UAS flies.

A Dp(2;2)AIF^T52/+ background fails to rescue the reduced adult eye size phenotype found in Scer\GAL4^hs.2sev->Mmus\Gria1^Lc.Scer\UAS flies.

A puc^E69/+ background increases the severity the reduced adult eye size phenotype found in Scer\GAL4^hs.2sev->Mmus\Gria1^Lc.Scer\UAS flies.

Expression of bsk^DN.Scer\UAS under the control of Scer\GAL4^hs.2sev has no effect on the reduced adult eye size phenotype found in Scer\GAL4^hs.2sev->Mmus\Gria1^Lc.Scer\UAS flies.

Expression of hep^{dsRNA.Scer\UAS.cUa} under the control of Scer\GAL4^hs.2sev has no effect on the reduced adult eye size phenotype found in Scer\GAL4^hs.2sev->Mmus\Gria1^Lc.Scer\UAS flies.

A bsk¹ heterozygous background, in the presence of BacA\p35^GMR.PH, generates additional rescue of the Scer\GAL4^hs.2sev->Mmus\Gria1^Lc.Scer\UAS eye phenotype compared to BacA\p35^GMR.PH alone.

A puc^E69/+ background further enhances the rescue found in BacA\p35^GMR.PH;Scer\GAL4^hs.2sev->Mmus\Gria1^Lc.Scer\UAS flies.

Down-regulation of ND75 through expression of ND75^GD6309 in Scer\GAL4^hs.2sev->Mmus\Gria1^Lc.Scer\UAS necrotic neurons enhances ROS production and activated JNK signaling.

Overexpression of Cat^Scer\UAS.cAa in Scer\GAL4^hs.2sev->Mmus\Gria1^Lc.Scer\UAS necrotic neurons reduces the eye defect and JNK activation without affecting primary necrosis.

Overexpression of Cat^Scer\UAS.cAa and PHGPx^Scer\UAS.cMa in Scer\GAL4^hs.2sev->Mmus\Gria1^Lc.Scer\UAS necrotic neurons reduces the eye defect and JNK activation without affecting primary necrosis.

A Df(3L)ED224 background rescues the reduced adult eye size phenotype found in Scer\GAL4^hs.2sev->Mmus\Gria1^Lc.Scer\UAS flies.

A Df(3L)ED225 background weakly rescues the reduced adult eye size phenotype found in Scer\GAL4^hs.2sev->Mmus\Gria1^Lc.Scer\UAS flies.

A Df(1)C246 background rescues the reduced adult eye size phenotype found in Scer\GAL4^hs.2sev->Mmus\Gria1^Lc.Scer\UAS flies.

A Df(2L)cact-255rv64 background rescues the reduced adult eye size phenotype found in Scer\GAL4^hs.2sev->Mmus\Gria1^Lc.Scer\UAS flies.

A Df(3L)vin5 background rescues the reduced adult eye size phenotype found in Scer\GAL4^hs.2sev->Mmus\Gria1^Lc.Scer\UAS flies.

A Df(2L)BSC5 background rescues the reduced adult eye size phenotype found in Scer\GAL4^hs.2sev->Mmus\Gria1^Lc.Scer\UAS flies.

A Df(3R)L127 background rescues the reduced adult eye size phenotype found in Scer\GAL4^hs.2sev->Mmus\Gria1^Lc.Scer\UAS flies.

A Df(3L)ED4408 background rescues the reduced adult eye size phenotype found in Scer\GAL4^hs.2sev->Mmus\Gria1^Lc.Scer\UAS flies.

The presence of Marf^JF01650 strongly enhances the reduced adult eye size phenotype found in Scer\GAL4^hs.2sev->Mmus\Gria1^Lc.Scer\UAS flies.

The presence of opa1-like^HMS00349 strongly enhances the reduced adult eye size phenotype found in Scer\GAL4^hs.2sev->Mmus\Gria1^Lc.Scer\UAS flies.

The presence of whd^HMS00033 strongly enhances the reduced adult eye size phenotype found in Scer\GAL4^hs.2sev->Mmus\Gria1^Lc.Scer\UAS flies.

The presence of wal^HMS01263 enhances the reduced adult eye size phenotype found in Scer\GAL4^hs.2sev->Mmus\Gria1^Lc.Scer\UAS flies.

A Df(3R)ED6346 background rescues the reduced adult eye size phenotype found in Scer\GAL4^hs.2sev->Mmus\Gria1^Lc.Scer\UAS flies.

A Df(2L)ED206 background rescues the reduced adult eye size phenotype found in Scer\GAL4^hs.2sev->Mmus\Gria1^Lc.Scer\UAS flies.

A Df(2R)ED1791 background rescues the reduced adult eye size phenotype found in Scer\GAL4^hs.2sev->Mmus\Gria1^Lc.Scer\UAS flies.

The P{EPgy2}EY00992 insertion weakly rescues the reduced adult eye size phenotype found in Scer\GAL4^hs.2sev->Mmus\Gria1^Lc.Scer\UAS flies.

The P{EPgy2}EY07585 insertion rescues the reduced adult eye size phenotype found in Scer\GAL4^hs.2sev->Mmus\Gria1^Lc.Scer\UAS flies.

A Df(3L)ED228 background rescues the reduced adult eye size phenotype found in Scer\GAL4^hs.2sev->Mmus\Gria1^Lc.Scer\UAS flies.

A Df(2L)ED1226 background rescues the reduced adult eye size phenotype found in Scer\GAL4^hs.2sev->Mmus\Gria1^Lc.Scer\UAS flies.

A Df(3R)ED6027 background rescues the reduced adult eye size phenotype found in Scer\GAL4^hs.2sev->Mmus\Gria1^Lc.Scer\UAS flies.

The P{EPgy2}EY05965 insertion strongly rescues the reduced adult eye size phenotype found in Scer\GAL4^hs.2sev->Mmus\Gria1^Lc.Scer\UAS flies.

A mbc^EY01437 background rescues the reduced adult eye size phenotype found in Scer\GAL4^hs.2sev->Mmus\Gria1^Lc.Scer\UAS flies.

A rok^HMS01311 background rescues the reduced adult eye size phenotype found in Scer\GAL4^hs.2sev->Mmus\Gria1^Lc.Scer\UAS flies.

A Rho1^HMS00375 background rescues the reduced adult eye size phenotype found in Scer\GAL4^hs.2sev->Mmus\Gria1^Lc.Scer\UAS flies.

A sqh^HMS00830 background rescues the reduced adult eye size phenotype found in Scer\GAL4^hs.2sev->Mmus\Gria1^Lc.Scer\UAS flies.

A Df(2L)ED1454 background rescues the reduced adult eye size phenotype found in Scer\GAL4^hs.2sev->Mmus\Gria1^Lc.Scer\UAS flies.

A Df(3L)ED208 background rescues the reduced adult eye size phenotype found in Scer\GAL4^hs.2sev->Mmus\Gria1^Lc.Scer\UAS flies.

The P{EPgy2}EY03589 insertion rescues the reduced adult eye size phenotype found in Scer\GAL4^hs.2sev->Mmus\Gria1^Lc.Scer\UAS flies.

A emb^EY08770 background strongly enhances the reduced adult eye size phenotype found in Scer\GAL4^hs.2sev->Mmus\Gria1^Lc.Scer\UAS flies.

A RanBP3^EY10605 background weakly rescues the reduced adult eye size phenotype found in Scer\GAL4^hs.2sev->Mmus\Gria1^Lc.Scer\UAS flies.

A emb^HMS00991 background rescues the reduced adult eye size phenotype found in Scer\GAL4^hs.2sev->Mmus\Gria1^Lc.Scer\UAS flies.

A lbm^EY02692 background rescues the reduced adult eye size phenotype found in Scer\GAL4^hs.2sev->Mmus\Gria1^Lc.Scer\UAS flies.

A Nsf2^HMS01262 background rescues the reduced adult eye size phenotype found in Scer\GAL4^hs.2sev->Mmus\Gria1^Lc.Scer\UAS flies.

A Wnt2^HMS01613 background rescues the reduced adult eye size phenotype found in Scer\GAL4^hs.2sev->Mmus\Gria1^Lc.Scer\UAS flies.

A Df(3L)ED4606 background rescues the reduced adult eye size phenotype found in Scer\GAL4^hs.2sev->Mmus\Gria1^Lc.Scer\UAS flies.

A Df(3L)ED4457 background rescues the reduced adult eye size phenotype found in Scer\GAL4^hs.2sev->Mmus\Gria1^Lc.Scer\UAS flies.

A Df(3L)ED4486 background rescues the reduced adult eye size phenotype found in Scer\GAL4^hs.2sev->Mmus\Gria1^Lc.Scer\UAS flies.

A Df(3R)ED10642 background rescues the reduced adult eye size phenotype found in Scer\GAL4^hs.2sev->Mmus\Gria1^Lc.Scer\UAS flies.

A Df(2R)ED2436 background rescues the reduced adult eye size phenotype found in Scer\GAL4^hs.2sev->Mmus\Gria1^Lc.Scer\UAS flies.

A Df(3L)Exel9003 background rescues the reduced adult eye size phenotype found in Scer\GAL4^hs.2sev->Mmus\Gria1^Lc.Scer\UAS flies.

The P{EPgy2}EY07592 insertion rescues the reduced adult eye size phenotype found in Scer\GAL4^hs.2sev->Mmus\Gria1^Lc.Scer\UAS flies.

A Cyt-c-d^bln1/+ background rescues the reduced adult eye size phenotype found in Scer\GAL4^hs.2sev->Mmus\Gria1^Lc.Scer\UAS flies.

A wal⁰²⁵¹⁶/+ background rescues the reduced adult eye size phenotype found in Scer\GAL4^hs.2sev->Mmus\Gria1^Lc.Scer\UAS flies.

A BacA\p35^GMR.PH/+ background strongly rescues the adult eye size defect found upon expression of Mmus\Gria1^Lc.Scer\UAS under the control of Scer\GAL4^hs.2sev in a wal⁰²⁵¹⁶/+ background.

A BacA\p35^GMR.PH/+ background strongly rescues the adult eye size defect found upon expression of Mmus\Gria1^Lc.Scer\UAS under the control of Scer\GAL4^hs.2sev in a Df(3L)vin5/+ background.

A BacA\p35^GMR.PH/+ background strongly rescues the adult eye size defect found upon expression of Mmus\Gria1^Lc.Scer\UAS under the control of Scer\GAL4^hs.2sev in a Df(2L)cact-255rv64/+ background.

A BacA\p35^GMR.PH/+ background strongly rescues the adult eye size defect found upon expression of Mmus\Gria1^Lc.Scer\UAS under the control of Scer\GAL4^hs.2sev in a Cyt-c-d^bln1/+ background.

A BacA\p35^GMR.PH/+ background fails to suppress the adult eye size defect found upon co-expression of Mmus\Gria1^Lc.Scer\UAS and Marf^JF01650 under the control of Scer\GAL4^hs.2sev.

A BacA\p35^GMR.PH/+ background fails to suppress the adult eye size defect found upon co-expression of Mmus\Gria1^Lc.Scer\UAS and wal^HMS01263 under the control of Scer\GAL4^hs.2sev.

Knocking down egr in necrotic neurons in Scer\GAL4^hs.2sev->Mmus\Gria1^Lc.Scer\UAS/egr^{dsRNA.Scer\UAS} flies rescues the eye size defect in Mmus\Gria1^Lc.Scer\UAS-expressing flies without affecting the primary necrosis.

Overexpression of egr^Scer\UAS.cIa in necrotic Scer\GAL4^hs.2sev->Mmus\Gria1^Lc.Scer\UAS neurons enhances the eye size defect seen upon expression of Mmus\Gria1^Lc.Scer\UAS alone.

Inhibition of apoptosis, through co-expression of Iap2^Scer\UAS.cLa does not affect the Mmus\Gria1^Lc.Scer\UAS eye defect (when all are expressed under the control of Scer\GAL4^hs.2sev.

Inhibition of apoptosis, through co-expression of th^Scer\UAS.cUa, does not affect the Mmus\Gria1^Lc.Scer\UAS eye defect (when all are expressed under the control of Scer\GAL4^hs.2sev.

A BacA\p35^GMR.PH/+ background strongly rescues the adult eye size defect found upon expression of Mmus\Gria1^Lc.Scer\UAS under the control of Scer\GAL4^hs.2sev. Non-neuronal cells, but not R cells, are strongly rescued.

A bsk¹ heterozygous background, in the presence of BacA\p35^GMR.PH, generates additional rescue of the Scer\GAL4^hs.2sev->Mmus\Gria1^Lc.Scer\UAS eye phenotype compared to BacA\p35^GMR.PH/+ alone.

Inhibition of apoptosis, through co-expression of BacA\p35^Scer\UAS.cUa does not affect the Mmus\Gria1^Lc.Scer\UAS eye defect (when all are expressed under the control of Scer\GAL4^hs.2sev.

(Yang et al., 2013)

Complementation and Rescue Data

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Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Mmus\Gria1^Lc.Scer\UAS

Mmus\Gria1^Lc.UAS

Name Synonyms

Secondary FlyBase IDs

References (6)

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