FlyBase Allele Report: Dmel\Tis11[IE35]

General Information

Symbol

Dmel\Tis11^IE35

Species

D. melanogaster

Name

FlyBase ID

FBal0294011

Feature type

allele

Associated gene

Dmel\Tis11

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

amorphic allele - molecular evidence

Mutagen

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Choi et al., 2014, Fedic et al., 2012.12.18)

Mutagen

Delta2-3 transposase

(Choi et al., 2014)

P-element activity

(Fedic et al., 2012.12.18)

Progenitor genotype

P{EP}Tis11^G0147

(Choi et al., 2014, Fedic et al., 2012.12.18)

Caused by aberration

Df(1)IE35

Cytology

Description

Imprecise excision of P{EP}Tis11^G0147 that deletes Tis11 from the P element insertion site and extends into the neighboring Smr locus. The size of the deletion is approximately 200 kb.

(Choi et al., 2014)

Tis11^IE35 is associated with the distal breakpoint of Df(1)IE35, which deletes the Tis11 coding region.

(Fedic et al., 2012.12.18)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal developmental rate (with Dp(1;Y)BSC5)

(Choi et al., 2014)

fertile (with Dp(1;Y)BSC5)

(Choi et al., 2014)

viable (with Dp(1;Y)BSC5)

(Choi et al., 2014)

Phenotype Manifest In

Detailed Description

Statement

Reference

Tis11^IE35/Dp(1;Y)BSC5 males are viable, fertile, and appear normal, although they exhibit a modest (approximately 24h) delay in eclosion.

(Choi et al., 2014)

Df(1)IE35 males rescued by Dp(1;Y)BSC5, which does not include Tis11, are viable and fertile.

(Fedic et al., 2012.12.18)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Tis11^IE35, brat^DG19310/brat¹¹ has increased cell number | larval stage phenotype, suppressible by dpn[+]/dpn¹

(Komori et al., 2018)

Enhancer of

Statement

Reference

Tis11[+], Scer\GAL4^wor.PA, Tis11^{ΔNot1.UAS.Tag:FLAG}, Tis11^IE35, Scer\GAL80^ase.PU is an enhancer of increased cell growth rate | larval stage phenotype of brat^DG19310/brat¹¹

(Komori et al., 2018)

Tis11[+]/Tis11^IE35 is an enhancer of increased cell number | larval stage phenotype of brat^DG19310/brat¹¹

(Komori et al., 2018)

Tis11^{H198Q.UAS.Tag:FLAG}, Tis11[+], Scer\GAL4^wor.PA, Tis11^IE35, Scer\GAL80^ase.PU is an enhancer of increased cell growth rate | larval stage phenotype of brat^DG19310/brat¹¹

(Komori et al., 2018)

NOT Enhancer of

Statement

Reference

Tis11[+], Scer\GAL4^wor.PA, Tis11^{UAS.cKa.Tag:FLAG}, Tis11^IE35, Scer\GAL80^ase.PU is a non-enhancer of increased cell growth rate | larval stage phenotype of brat^DG19310/brat¹¹

(Komori et al., 2018)

Phenotype Manifest In

Suppressed by

Statement

Reference

Tis11^IE35, brat^DG19310/brat¹¹ has type II neuroblast | increased number | larval stage phenotype, suppressible by dpn[+]/dpn¹

(Komori et al., 2018)

Tis11^IE35, brat^DG19310/brat¹¹ has embryonic/larval optic lobe | larval stage phenotype, suppressible by dpn[+]/dpn¹

(Komori et al., 2018)

Enhancer of

Statement

Reference

Tis11[+]/Tis11^IE35 is an enhancer of type II neuroblast | larval stage | increased number phenotype of brat^DG19310/brat¹¹

(Komori et al., 2018)

Tis11[+]/Tis11^IE35 is an enhancer of embryonic/larval optic lobe | larval stage | increased number phenotype of brat^DG19310/brat¹¹

(Komori et al., 2018)

Tis11[+], Scer\GAL4^wor.PA, Tis11^{ΔNot1.UAS.Tag:FLAG}, Tis11^IE35, Scer\GAL80^ase.PU is an enhancer of embryonic/larval optic lobe | larval stage phenotype of brat^DG19310/brat¹¹

(Komori et al., 2018)

Tis11^{H198Q.UAS.Tag:FLAG}, Tis11[+], Scer\GAL4^wor.PA, Tis11^IE35, Scer\GAL80^ase.PU is an enhancer of type II neuroblast | larval stage | increased number phenotype of brat^DG19310/brat¹¹

(Komori et al., 2018)

Tis11^{H198Q.UAS.Tag:FLAG}, Tis11[+], Scer\GAL4^wor.PA, Tis11^IE35, Scer\GAL80^ase.PU is an enhancer of embryonic/larval optic lobe | larval stage phenotype of brat^DG19310/brat¹¹

(Komori et al., 2018)

Tis11[+], Scer\GAL4^wor.PA, Tis11^{ΔNot1.UAS.Tag:FLAG}, Tis11^IE35, Scer\GAL80^ase.PU is an enhancer of type II neuroblast | larval stage | increased number phenotype of brat^DG19310/brat¹¹

(Komori et al., 2018)

NOT Enhancer of

Statement

Reference

Tis11[+], Scer\GAL4^wor.PA, Tis11^{UAS.cKa.Tag:FLAG}, Tis11^IE35, Scer\GAL80^ase.PU is a non-enhancer of embryonic/larval optic lobe | larval stage | increased number phenotype of brat^DG19310/brat¹¹

(Komori et al., 2018)

Tis11[+], Scer\GAL4^wor.PA, Tis11^{UAS.cKa.Tag:FLAG}, Tis11^IE35, Scer\GAL80^ase.PU is a non-enhancer of type II neuroblast | larval stage | increased number phenotype of brat^DG19310/brat¹¹

(Komori et al., 2018)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

42233

y¹ w^* Df(1)IE35, Tis11^IE35/FM7i, P{ActGFP}JMR3/Dp(1;Y)BSC5, y⁺

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Df(1)Tis11-IE35

(Choi et al., 2014)

IE35

(Choi et al., 2014)

Tis11^IE35

(Fedic et al., 2012.12.18)

tis11^IE35

(Komori et al., 2018)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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