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General Information
Symbol
Dmel\NosUAS.cUa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Unknown
FlyBase ID
FBal0294069
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-NOS
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UAS regulatory sequences drive expression of Nos.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Ectopic expression of NosScer\UAS.cUa under the control of Scer\GAL4phm.PO and in the absence of any tissue damage inhibits eye disc growth in third instar larvae compared to age-matched controls.

Over-expression of NosScer\UAS.cUa driven in glia by Scer\GAL4repo.PU does not produce toxicity.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
NOT suppressed by
Enhancer of
NOT Enhancer of
Additional Comments
Genetic Interactions
Statement
Reference

The eye disc growth inhibition (in the absence of tissue damage) observed in third instar larvae expressing NosScer\UAS.cUa under the control of Scer\GAL4phm.PO cannot be suppressed by co-expression of Lgr3GL01056 (together with UAS-Dicer2 to enhance RNAi efficiency).

Xenogenetic Interactions
Statement
Reference

Co-expression of NosScer\UAS.cUa significantly enhances cell death (in both glia and non-autonomously in neurons) and seizure frequency in flies with expression of Hsap\GFAPR79H.Scer\UAS driven by Scer\GAL4repo.PU. Co-expression of NosScer\UAS.cUa does not significantly alter neurodegeneration in flies with expression of Hsap\ATXN3tr.Q78.Scer\UAS.T:Ivir\HA1 driven by Scer\GAL4repo.PU.

Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
NosScer\UAS.cUa
NosUAS.cUa
Name Synonyms
Saccharomyces cerevisiae UAS construct a of Unknown
Secondary FlyBase IDs
    References (3)