FB2025_05 , released December 11, 2025
Allele: Dmel\α-CatUASp.ΔVH2C.Tag:HA
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General Information
Symbol
Dmel\α-CatUASp.ΔVH2C.Tag:HA
Species
D. melanogaster
Name
FlyBase ID
FBal0294101
Feature type
allele
Associated gene
Dmel\α-Cat
Associated Insertion(s)
Carried in Construct
P{UASp-α-Cat.ΔVH2C.HA}
Key Links
Transgenic product class
inframe_deletion
(Desai et al., 2013)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Desai et al., 2013)
Mutagen
in vitro construct
(Desai et al., 2013)
Progenitor genotype
Carried in construct
P{UASp-α-Cat.ΔVH2C.HA}
Cytology
Description

UASp regulatory sequences drive expression of a mutant form of α-Cat lacking amino acids 510-627. The construct is tagged at the C-terminal end with Tag:HA.

(Desai et al., 2013)
Allele components
Component
Use(s)
Regulatory region(s)
UASp
Encoded product / tool
α-Cat
Tagged with
Tag:HA
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      Scer\GAL4Act.PU, Scer\GAL4da.G32, α-CatUASp.ΔVH2C.Tag:HA partially rescues α-Cat1

      (Desai et al., 2013)
      Comments

      Expression of α-CatScer\UAS.P\T.ΔVH2C.T:Ivir\HA1 under the control of Scer\GAL4da.G32 and Scer\GAL4Act.PU fully rescues the follicular epithelium cell phenotypes seen in α-Cat1 mutant follicle cell clones (generated through recombination of the α-CatUbi.PS rescue construct). The border cell migration defects are almost completely rescued.

      Ubiquitous expression of α-CatScer\UAS.P\T.ΔVH2C.T:Ivir\HA1 under the control of Scer\GAL4da.G32 and Scer\GAL4Act.PU rescues the embryonic head defects seen in α-Cat1 mutant embryos. The lethality is partially rescued; some adults are recovered but many animals are unable to develop beyond the larval and pupal stages.

      (Desai et al., 2013)
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      α-CatScer\UAS.P\T.ΔVH2C.T:Ivir\HA1
      α-CatUASp.ΔVH2C.Tag:HA
      Name Synonyms
      Secondary FlyBase IDs
        References (1)