FlyBase Allele Report: Mmus\Ctnna2[Δ56.Ubi]

General Information

Symbol

Mmus\Ctnna2^Δ56.Ubi

Species

M. musculus

Name

FlyBase ID

FBal0294111

Feature type

allele

Associated gene

Mmus\Ctnna2

Associated Insertion(s)

Carried in Construct

P{Ubi-Ctnna2.Δ56}

Transgenic product class

inframe_deletion

(Sarpal et al., 2016.7.28)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

inframe_deletion

(Sarpal et al., 2016.7.28)

Mutagen

in vitro construct

(Desai et al., 2013)

Progenitor genotype

Carried in construct

P{Ubi-Ctnna2.Δ56}

Cytology

Description

A ubiquitin promoter drives expression of a mutant form of Mmus\Ctnna2 lacking the first 56 amino acids.

(Sarpal et al., 2016.7.28)

Allele components

Component

Use(s)

Encoded product / tool

Mmus\Ctnna2

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Scer\GAL4^Act.PU, Mmus\Ctnna2^Δ56.Ubi, Scer\GAL4^da.G32 is a suppressor | partially of lethal - all die during embryonic stage phenotype of α-Cat¹

(Desai et al., 2013)

NOT Suppressor of

Statement

Reference

Scer\GAL4^Act.PU, Mmus\Ctnna2^Δ56.Ubi, Scer\GAL4^da.G32 is a non-suppressor of abnormal cell migration | somatic clone phenotype of α-Cat¹

(Desai et al., 2013)

Other

Statement

Reference

α-Cat¹, Mmus\Ctnna2^Δ56.Ubi, Scer\GAL4^Act.PU, Scer\GAL4^da.G32 has lethal - all die before end of larval stage phenotype

(Desai et al., 2013)

Phenotype Manifest In

Suppressor of

Statement

Reference

Scer\GAL4^Act.PU, Mmus\Ctnna2^Δ56.Ubi, Scer\GAL4^da.G32 is a suppressor | partially of embryonic head phenotype of α-Cat¹

(Desai et al., 2013)

NOT Suppressor of

Statement

Reference

Scer\GAL4^Act.PU, Mmus\Ctnna2^Δ56.Ubi, Scer\GAL4^da.G32 is a non-suppressor of follicle cell | somatic clone phenotype of α-Cat¹

(Desai et al., 2013)

Scer\GAL4^Act.PU, Mmus\Ctnna2^Δ56.Ubi, Scer\GAL4^da.G32 is a non-suppressor of border follicle cell | somatic clone phenotype of α-Cat¹

(Desai et al., 2013)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Expression of Mmus\Ctnna2^{Δ56.Scer\UAS.P\T} under the control of Scer\GAL4^da.G32 and Scer\GAL4^Act.PU fails to suppress the follicular epithelium cell phenotypes seen in α-Cat¹ mutant follicle cell clones (generated through recombination of the α-Cat^Ubi.PS rescue construct). The border cell migration defects are not rescued.

Ubiquitous expression of Mmus\Ctnna2^{Δ56.Scer\UAS.P\T} under the control of Scer\GAL4^da.G32 and Scer\GAL4^Act.PU partially rescues the head involution defects seen in α-Cat¹ mutant embryos. Some animals are able to develop to the larval stages.

(Desai et al., 2013)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

66200

w¹¹¹⁸; P{Ubi-Ctnna2.Δ56}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Mmus\Ctnna2^{Δ56.Scer\UAS.P\T}

Mmus\Ctnna2^Δ56.Ubi

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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