FlyBase Allele Report: Scer\GAL4[Hand.ΔVM.Switch]

General Information

Symbol

Scer\GAL4^{Hand.ΔVM.Switch}

Species

S. cerevisiae

Name

FlyBase ID

FBal0294215

Feature type

allele

Associated gene

Scer\GAL4

Associated Insertion(s)

Carried in Construct

P{Hand-GAL4.ΔVM.Switch}

Also Known As

Hand-GS, HandGS

Transgenic product class

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

Mutagen

in vitro construct

(Monnier et al., 2012)

Progenitor genotype

Carried in construct

P{Hand-GAL4.ΔVM.Switch}

Cytology

Description

The HandΔVM enhancer and a hsp70 minimal promoter drive expression of the GAL4::GS ligand-inducible driver.

(Monnier et al., 2012)

Allele components

Component

Use(s)

Regulatory region(s)

Hand

Encoded product / tool

GAL4::GS

binary expression system - small molecule-regulated driver

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

distribution deduced from reporter (Gal4 UAS)

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult heart

(Tricoire et al., 2014, Monnier et al., 2012)

Additional Information

Statement

Reference

ScerGAL4^{Hand.ΔVM.Switch} drives mifepristone-inducible expression in the adult heart.

(Tricoire et al., 2014, Monnier et al., 2012)

Marker for

Reflects expression of

Hand

(Tricoire et al., 2014, Monnier et al., 2012)

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

increased size | adult stage, with cher^JF02077, cher^KK107518

(Ader et al., 2022)

Phenotype Manifest In

adult cardial cell, with cher^JF02077, cher^KK107518

(Ader et al., 2022)

adult heart, with cher^JF02077

(Ader et al., 2022)

adult heart, with cher^JF02077, cher^KK107518

(Ader et al., 2022)

adult heart, with cher^KK107518

(Ader et al., 2022)

adult heart | adult stage | RU486 conditional, with fh^RNAi.UAS.cAa

(Tricoire et al., 2014)

adult heart | progressive | RU486 conditional, with Cat^GD1291

(Monnier et al., 2012)

adult heart | RU486 conditional, with Cat^UAS.cAa

(Monnier et al., 2012)

adult heart | RU486 conditional, with CatB^UAS.cMa

(Monnier et al., 2012)

adult heart | RU486 conditional, with Cyt-c1^GD3851

(Tricoire et al., 2014)

adult heart | RU486 conditional, with Hsap\HTT^{171aa.138Q.UAS.Tag:HA}

(Heidari et al., 2015)

adult heart | RU486 conditional, with Hsap\HTT^Q93.ex1.UAS

(Heidari et al., 2015)

adult heart | RU486 conditional, with Jra^GD4400

(Monnier et al., 2012)

adult heart | RU486 conditional, with Jra^JF01184

(Monnier et al., 2012)

adult heart | RU486 conditional, with Jra^UAS.cEa

(Monnier et al., 2012)

adult heart | RU486 conditional, with kay^GD1469

(Monnier et al., 2012)

adult heart | RU486 conditional, with ND-20^GD17854

(Tricoire et al., 2014)

adult heart | RU486 conditional, with ND-49^GD6427

(Tricoire et al., 2014)

adult heart | RU486 conditional, with ND-B14.5B^GD3652

(Tricoire et al., 2014)

adult heart | RU486 conditional, with UQCR-14L^GD9481

(Tricoire et al., 2014)

adult heart | RU486 conditional, with vri^2.UAS

(Monnier et al., 2012)

adult heart | RU486 conditional, with vri^RNAi.UAS.cTa

(Monnier et al., 2012)

adult heart chamber 1 | adult stage, with cher^JF02077, cher^KK107518

(Ader et al., 2022)

sarcomere | adult stage, with cher^JF02077, cher^KK107518

(Ader et al., 2022)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressed by

Statement

Reference

Scer\GAL4^{Hand.ΔVM.Switch}, fh^RNAi.UAS.cAa has adult heart | RU486 conditional phenotype, suppressible by Hsap\FXN^UAS.cTa, Scer\GAL4^{Hand.ΔVM.Switch}

(Tricoire et al., 2014)

NOT suppressed by

Statement

Reference

Scer\GAL4^{Hand.ΔVM.Switch}, fh^RNAi.UAS.cAa has adult heart | RU486 conditional phenotype, non-suppressible by Cat^UAS.cAa, Scer\GAL4^{Hand.ΔVM.Switch}

(Tricoire et al., 2014)

Suppressor of

Statement

Reference

Hsap\FXN^UAS.cTa, Scer\GAL4^{Hand.ΔVM.Switch} is a suppressor of adult heart | RU486 conditional phenotype of Scer\GAL4^{Hand.ΔVM.Switch}, fh^RNAi.UAS.cAa

(Tricoire et al., 2014)

NOT Suppressor of

Statement

Reference

Cat^UAS.cAa, Scer\GAL4^{Hand.ΔVM.Switch} is a non-suppressor of adult heart | RU486 conditional phenotype of Scer\GAL4^{Hand.ΔVM.Switch}, fh^RNAi.UAS.cAa

(Tricoire et al., 2014)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Scer\GAL4^{Hand.ΔVM.Switch}

Name Synonyms

Secondary FlyBase IDs

References (11)

Report Sections

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