FB2025_02 , released April 17, 2025
Allele: Dmel\kay3
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General Information
Symbol
Dmel\kay3
Species
D. melanogaster
Name
FlyBase ID
FBal0295278
Feature type
allele
Associated gene
Dmel\kay
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 1 )
        Disease
        Interaction
        References
        ameliorates  cancer
        modeled by Ras85DV12.UAS, scrib1
        (Külshammer et al., 2015)
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        Third instar larval eye-antennal imaginal disc clones homozygous for scrib1 and expressing Ras85DV12.Scer\UAS under the control of Scer\GAL4Act.PU do not induce significant autophagosomes (assessed by a Atg8a fluorescence reporter) in neighboring disc cells if the clones are also homozygous for kay3.

        (Katheder et al., 2017)

        Addition of a clonal kay3 mutation partially suppresses the lethality and developmental delay seen in larvae with scrib1 mutant eye-antennal disc clones expressing Ras85DV12.Scer\UAS under the control of Scer\GAL4Act.PU, and suppresses the invasive infiltration of the ventral nerve cord exhibited by cells of these clones, although the tumor mass is not significantly decreased.

        Addition of a clonal kay3 mutation partially suppresses the defective photoreceptor differentiation seen in scrib1 mutant eye-antennal disc clones expressing Ras85DV12.Scer\UAS under the control of Scer\GAL4Act.PU.

        Larvae with scrib1, kay3 mutant eye-antennal disc clones expressing Ras85DV12.Scer\UAS and Ets21CKK103211 under the control of Scer\GAL4Act.PU exhibit suppression of larval lethality as compared to either larvae with scrib1, kay3 mutant eye-antennal disc clones expressing Ras85DV12.Scer\UAS under the control of Scer\GAL4Act.PU, or those with scrib1 mutant eye-antennal disc clones expressing Ras85DV12.Scer\UAS and Ets21CKK103211 under the control of Scer\GAL4Act.PU; but these larvae still exhibit pupal lethality.

        (Külshammer et al., 2015)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        kay3
        (Katheder et al., 2017, Külshammer et al., 2015, Beira et al., 2014, Külshammer and Uhlirova, 2013)
        Name Synonyms
        Secondary FlyBase IDs
          References (4)