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General Information
Symbol
Dmel\tkvTIPF.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0295300
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-TIPF, UAS-tkv-TIPF
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of 'TIPF', a sensor that can be used to assay tkv activation. It consists of tkv isoform-D coding sequences fused to the conformation-sensitive circularly permutated yellow fluorescent protein (cpYFP) and FKBP12 (a motif that binds to the unphosphorylated glycine-serine rich domain of inactive type I BMP receptors). Activation of tkv displaces the FKBP12 motif, allowing cpYFP to adopt a fluorescent conformation.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
tkvD.Scer\UAS.T:Avic\GFP-cpYFP,T:FKBP12
tkvTIPF.UAS
Name Synonyms
Secondary FlyBase IDs
    References (6)