FB2025_01 , released February 20, 2025
Allele: Dmel\Atg18aVDRC.cUa
Open Close
General Information
Symbol
Dmel\Atg18aVDRC.cUa
Species
D. melanogaster
Name
FlyBase ID
FBal0295306
Feature type
allele
Associated gene
Dmel\Atg18a
Associated Insertion(s)
Carried in Construct
P{VDRC.Atg18a.U}
Key Links
Transgenic product class
RNAi_reagent
(Denton et al., 2012)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Denton et al., 2012)
Mutagen
in vitro construct
(Denton et al., 2012)
Progenitor genotype
Carried in construct
P{VDRC.Atg18a.U}
Cytology
Description

UAS regulates expression of a Atg18a RNAi construct.

(Denton et al., 2012)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Atg18a
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      exacerbates  Parkinson's disease 6
      modeled by Pink1RNAi.UAS.cYa
      (Liu and Lu, 2010)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Scer\GAL4Myo31DF-NP0001-mediated expression of Atg18VDRC.cUa results in persistent PI3K signalling in the midgut at +2h relative puparium formation, as assayed by localization of phospho-Akt1.

      Scer\GAL4Myo31DF-NP0001-mediated expression of Atg18VDRC.cUa severely delays midgut removal.

      (Denton et al., 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The midgut phenotype seen in Atg18VDRC.cUa Scer\GAL4Myo31DF-NP0001 animals is suppressed by co-expression of PtenScer\UAS.cUa or coexpression of Tsc1Scer\UAS.cTa and gigScer\UAS.cTa.

      (Denton et al., 2012)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Atg18VDRC.cUa
      Atg18aVDRC.cUa
      Name Synonyms
      Secondary FlyBase IDs
        References (2)