FlyBase Allele Report: Hsap\APP[Aβ42.UAS.cUa]

Expression of Hsap\APP^{Aβ42.Scer\UAS.cUa} under the control of Scer\GAL4^GMR.PU results in a severe reduction in the size of the adult eye as compared to wild type, and the eye has a glazed appearance due to the fusion of lenses; third instar eye discs from these mutants show a significant increase in cell death and defective axonal targeting of the retinal neurons, as compared to controls.

(Cutler et al., 2015)

Expression of Hsap\APP^{Aβ42.Scer\UAS.cUa} under the control of Scer\GAL4^elav-C155 results in age-progressive neurodegeneration (vacuole lesions in the brain of aged adult flies) and earlier and more severe age-related decline in climbing ability.

(Nevzglyadova et al., 2015)

Flies expressing Hsap\APP^{Aβ42.Scer\UAS.cUa} in the central nervous system under the control of Scer\GAL4^elav.PU display disease phenotypes, including reduced longevity and a gradual decline of locomotive ability. Feeding flies with compound D737 (C[[25]]H[[20]]N[[2O]]) increases longevity of the flies compared with controls. Similarly, feeding flies with D737 analogues D744, D830, D979 and D742 also results in improved longevity. The most effective of these compounds (D744) produces a life span curve for the transgenic flies that is fairly close to that of wild-type. Compound D737 and all four analogues also ameliorate the climbing defects in the transgenic flies.

(McKoy et al., 2014)

Expression of Hsap\APP^{Aβ42.Scer\UAS.cUa} in the wing, under the control of Scer\GAL4^Bx-MS1096, generates ectopic and defective wing vein formation. Addition of KSOP1009 to the food media suppresses defective wing vein formation. Addition of PD98059 to the food media suppresses defective wing vein formation.

Expression of Hsap\APP^{Aβ42.Scer\UAS.cUa} under the control of Scer\GAL4^elav-C155 decreases climbing ability, compared to wild-type flies. Addition of 50υM PD98059 to the food media for these flies restores climbing ability. Addition of 5υg/mL KSOP1009 also restores climbing ability in these flies.

Pan-neuronal expression of Hsap\APP^{Aβ42.Scer\UAS.cUa}, under the control of Scer\GAL4^elav-C155, increases the number of glial cells in the larval brain. Addition of 5υg/mL KSOP1009 to fly media almost completely restores the number of glial cells in mutant larval brains to control levels. Addition of PD98059 does not affect glial cell proliferation.

(Park et al., 2013)

Expression of Hsap\APP^{Aβ42.Scer\UAS.cUa} under the control of Scer\GAL4^GMR.PU results in reduced eyes with a glazed surface. Mutant eye imaginal discs show an almost three-fold increase in TUNEL-positive cells compared to controls. Aberrant axonal targeting from the retina to the brain is seen, with the retinal axons failing to innervate the medulla and lamina and ending abruptly.

(Steffensmeier et al., 2013)

Scer\GAL4^elav.PU-mediated expression of Hsap\APP^{Aβ42.Scer\UAS.cUa} increases apoptosis in the larval brain.

Scer\GAL4^elav.PU, Hsap\APP^{Aβ42.Scer\UAS.cUa} flies have impaired climbing ability.

(Hong et al., 2012)

Female flies expressing Hsap\APP^{Aβ42.Scer\UAS.cUa} in the developing nervous system, under the control of Scer\GAL4^elav-C155, show reduced longevity and exhibit a gradual decline in locomotive ability.

(McKoy et al., 2012)

Defects can be seen in the third larval instar eye disc in animals expressing Hsap\APP^{Aβ42.Scer\UAS.cUa} under the control of Scer\GAL4^GMR.PU. Improper spacing of the differentiating photoreceptors and mild fusion of the ommatidial clusters is seen. At the prepupal stage, mild to stronger fusion of the ommatidial clusters is seen resulting in clumps of photoreceptors and loss of photoreceptors in the ommatidium. The phenotype becomes progressively more severe during the pupal stage, with multiple fusions of ommatidia and holes in the retina where ommatidial clusters have been extruded. The adult eye is severely diminished in size and shows ommatidial fusion, which in severe cases leads to a glazed appearance. The retina of the adult eye is very thin, has poorly differentiated photoreceptors and is vacuolated, and the overlying lenses are fused with it.

TUNEL positive cells begin to appear as early as the late third larval instar in the eye discs of animals expressing Hsap\APP^{Aβ42.Scer\UAS.cUa} under the control of Scer\GAL4^GMR.PU.

(Tare et al., 2011)

Motor neurons of larvae expressing Hsap\APP^{Aβ42.Scer\UAS.cUa} under the control of Scer\GAL4^Toll-6-D42 display normal axonal transport.

Expression of Hsap\APP^{Aβ42.Scer\UAS.cUa} under the control of Scer\GAL4^Toll-6-D42 leads to subtle morphological aberrations of larval neuromuscular junctions (NMJs) which includes the appearance of "satellite" boutons and thinning of inter-bouton regions.

The locomotor performance of flies expressing Scer\GAL4^unspecified>Hsap\APP^{Aβ42.Scer\UAS.cUa} is similar to that of control flies until they are about 12 days old, after which their climbing abilities undergo a steady age-related deterioration.

(Folwell et al., 2010)

External Data

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Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PU has size defective | adult stage phenotype, enhanceable by nej^ΔBHQ.UAS, Scer\GAL4^GMR.PU

(Cutler et al., 2015)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PU has increased cell death | third instar larval stage phenotype, enhanceable by nej^ΔBHQ.UAS, Scer\GAL4^GMR.PU

(Cutler et al., 2015)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PU has neuroanatomy defective | third instar larval stage phenotype, enhanceable by nej^ΔBHQ.UAS, Scer\GAL4^GMR.PU

(Cutler et al., 2015)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PU has increased cell death phenotype, enhanceable by crb^UAS.cWa, Scer\GAL4^GMR.PU

(Steffensmeier et al., 2013)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PU has increased cell death phenotype, enhanceable by hep^Act.UAS.cUa, Scer\GAL4^GMR.PU

(Tare et al., 2011)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PU has visible phenotype, enhanceable by hep^Act.UAS.cUa, Scer\GAL4^GMR.PU

(Tare et al., 2011)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PU has increased cell death phenotype, enhanceable by Jra^Asp.B.UAS, Scer\GAL4^GMR.PU

(Tare et al., 2011)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PU has visible phenotype, enhanceable by Jra^Asp.B.UAS, Scer\GAL4^GMR.PU

(Tare et al., 2011)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^Toll-6-D42 has neuroanatomy defective phenotype, enhanceable by Hsap\MAPT^UAS.1N4R, Scer\GAL4^Toll-6-D42

(Folwell et al., 2010)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^Toll-6-D42 has neuroanatomy defective phenotype, enhanceable by Hsap\MAPT^{R406W.UAS.1N4R}, Scer\GAL4^Toll-6-D42

(Folwell et al., 2010)

Suppressed by

Statement

Reference

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PU has size defective | adult stage phenotype, suppressible | partially by nej^UAS.Tag:V5, Scer\GAL4^GMR.PU

(Cutler et al., 2015)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PU has increased cell death | third instar larval stage phenotype, suppressible | partially by nej^UAS.Tag:V5, Scer\GAL4^GMR.PU

(Cutler et al., 2015)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PU has neuroanatomy defective | third instar larval stage phenotype, suppressible | partially by nej^UAS.Tag:V5, Scer\GAL4^GMR.PU

(Cutler et al., 2015)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PU has increased cell death | third instar larval stage phenotype, suppressible | partially by nej^{dsRNA.UAS.cKa}, Scer\GAL4^GMR.PU

(Cutler et al., 2015)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PU has size defective | adult stage phenotype, suppressible | partially by nej^ΔQ.UAS, Scer\GAL4^GMR.PU

(Cutler et al., 2015)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PU has increased cell death | third instar larval stage phenotype, suppressible | partially by nej^ΔQ.UAS, Scer\GAL4^GMR.PU

(Cutler et al., 2015)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PU has size defective | adult stage phenotype, suppressible | partially by nej^ΔHQ.UAS, Scer\GAL4^GMR.PU

(Cutler et al., 2015)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PU has increased cell death | third instar larval stage phenotype, suppressible | partially by nej^ΔHQ.UAS, Scer\GAL4^GMR.PU

(Cutler et al., 2015)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PU has size defective | adult stage phenotype, suppressible | partially by nej^ΔNZK.UAS, Scer\GAL4^GMR.PU

(Cutler et al., 2015)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PU has increased cell death | third instar larval stage phenotype, suppressible | partially by nej^ΔNZK.UAS, Scer\GAL4^GMR.PU

(Cutler et al., 2015)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PU has size defective | adult stage phenotype, suppressible | partially by nej^KIX.UAS, Scer\GAL4^GMR.PU

(Cutler et al., 2015)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PU has increased cell death | third instar larval stage phenotype, suppressible | partially by nej^KIX.UAS, Scer\GAL4^GMR.PU

(Cutler et al., 2015)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PU has visible phenotype, suppressible | partially by crb^GD14463, Scer\GAL4^GMR.PU

(Steffensmeier et al., 2013)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PU has increased cell death phenotype, suppressible | partially by crb^GD14463, Scer\GAL4^GMR.PU

(Steffensmeier et al., 2013)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PU has neuroanatomy defective phenotype, suppressible by crb^GD14463, Scer\GAL4^GMR.PU

(Steffensmeier et al., 2013)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PU has visible phenotype, suppressible | partially by crb^11A22

(Steffensmeier et al., 2013)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PU has increased cell death phenotype, suppressible | partially by crb^11A22

(Steffensmeier et al., 2013)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PU has neuroanatomy defective phenotype, suppressible by crb^11A22

(Steffensmeier et al., 2013)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PU has visible phenotype, suppressible by crb^{IntraΔERLI.UAS.Tag:MYC}, Scer\GAL4^GMR.PU

(Steffensmeier et al., 2013)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PU has increased cell death phenotype, suppressible by crb^{IntraΔERLI.UAS.Tag:MYC}, Scer\GAL4^GMR.PU

(Steffensmeier et al., 2013)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PU has neuroanatomy defective phenotype, suppressible by crb^{IntraΔERLI.UAS.Tag:MYC}, Scer\GAL4^GMR.PU

(Steffensmeier et al., 2013)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PU has visible phenotype, suppressible by crb^{IntraY10A.E16A.UAS.Tag:MYC}, Scer\GAL4^GMR.PU

(Steffensmeier et al., 2013)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PU has increased cell death phenotype, suppressible by crb^{IntraY10A.E16A.UAS.Tag:MYC}, Scer\GAL4^GMR.PU

(Steffensmeier et al., 2013)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PU has neuroanatomy defective phenotype, suppressible by crb^{IntraY10A.E16A.UAS.Tag:MYC}, Scer\GAL4^GMR.PU

(Steffensmeier et al., 2013)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PU has visible phenotype, suppressible by crb^{IntraY10A.E16A.ΔERLI.UAS.Tag:MYC}, Scer\GAL4^GMR.PU

(Steffensmeier et al., 2013)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PU has increased cell death phenotype, suppressible by crb^{IntraY10A.E16A.ΔERLI.UAS.Tag:MYC}, Scer\GAL4^GMR.PU

(Steffensmeier et al., 2013)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PU has neuroanatomy defective phenotype, suppressible by crb^{IntraY10A.E16A.ΔERLI.UAS.Tag:MYC}, Scer\GAL4^GMR.PU

(Steffensmeier et al., 2013)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^elav.PU has increased cell death | larval stage phenotype, suppressible by bsk¹/bsk[+]

(Hong et al., 2012)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^elav.PU has lethal phenotype, suppressible | partially by bsk¹/bsk[+]

(Hong et al., 2012)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^elav.PU has locomotor behavior defective phenotype, suppressible by bsk¹/bsk[+]

(Hong et al., 2012)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^elav.PU has increased cell death | larval stage phenotype, suppressible by hep¹

(Hong et al., 2012)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^elav.PU has increased cell death | larval stage phenotype, suppressible by Diap1^UAS.cHa, Scer\GAL4^elav.PU

(Hong et al., 2012)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^elav.PU has lethal phenotype, suppressible by Diap1^UAS.cHa, Scer\GAL4^elav.PU

(Hong et al., 2012)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^elav.PU has locomotor behavior defective phenotype, suppressible by Diap1^UAS.cHa, Scer\GAL4^elav.PU

(Hong et al., 2012)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^elav.PU has increased cell death | larval stage phenotype, suppressible by foxo²¹/foxo[+]

(Hong et al., 2012)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^elav.PU has lethal phenotype, suppressible | partially by foxo²¹/foxo[+]

(Hong et al., 2012)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^elav.PU has locomotor behavior defective phenotype, suppressible by foxo²¹/foxo[+]

(Hong et al., 2012)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^elav.PU has increased cell death | larval stage phenotype, suppressible by foxo²⁵/foxo[+]

(Hong et al., 2012)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^elav.PU has lethal phenotype, suppressible | partially by foxo²⁵/foxo[+]

(Hong et al., 2012)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^elav.PU has locomotor behavior defective phenotype, suppressible by foxo²⁵/foxo[+]

(Hong et al., 2012)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PU has visible phenotype, suppressible by bsk^DN.UAS, Scer\GAL4^GMR.PU

(Tare et al., 2011)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PU has increased cell death phenotype, suppressible | partially by BacA\p35^UAS.cHa, Scer\GAL4^GMR.PU

(Tare et al., 2011)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PU has increased cell death phenotype, suppressible | partially by puc^UAS.cMa, Scer\GAL4^GMR.PU

(Tare et al., 2011)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PU has neuroanatomy defective | progressive phenotype, suppressible | partially by puc^UAS.cMa, Scer\GAL4^GMR.PU

(Tare et al., 2011)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PU has increased cell death phenotype, suppressible by bsk^DN.UAS, Scer\GAL4^GMR.PU

(Tare et al., 2011)

NOT suppressed by

Statement

Reference

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PU has size defective | adult stage phenotype, non-suppressible by nej^{dsRNA.UAS.cKa}, Scer\GAL4^GMR.PU

(Cutler et al., 2015)

Enhancer of

Statement

Reference

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^unspecified is an enhancer of locomotor behavior defective | progressive phenotype of Hsap\MAPT^UAS.1N4R, Scer\GAL4^unspecified

(Folwell et al., 2010)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^unspecified is an enhancer of short lived | progressive phenotype of Hsap\MAPT^UAS.1N4R, Scer\GAL4^unspecified

(Folwell et al., 2010)

Other

Statement

Reference

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PU, nej^ΔBHQ.UAS has lethal - all die before end of P-stage phenotype

(Cutler et al., 2015)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PU, crb^UAS.cWa has lethal - all die during pupal stage phenotype

(Steffensmeier et al., 2013)

Phenotype Manifest In

Enhanced by

Statement

Reference

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PU has eye phenotype, enhanceable by nej^ΔBHQ.UAS, Scer\GAL4^GMR.PU

(Cutler et al., 2015)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PU has eye disc | third instar larval stage phenotype, enhanceable by nej^ΔBHQ.UAS, Scer\GAL4^GMR.PU

(Cutler et al., 2015)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PU has eye photoreceptor cell | third instar larval stage phenotype, enhanceable by nej^ΔBHQ.UAS, Scer\GAL4^GMR.PU

(Cutler et al., 2015)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PU has axon | third instar larval stage phenotype, enhanceable by nej^ΔBHQ.UAS, Scer\GAL4^GMR.PU

(Cutler et al., 2015)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PU has eye disc phenotype, enhanceable by crb^UAS.cWa, Scer\GAL4^GMR.PU

(Steffensmeier et al., 2013)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PU has eye disc phenotype, enhanceable by hep^Act.UAS.cUa, Scer\GAL4^GMR.PU

(Tare et al., 2011)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PU has eye phenotype, enhanceable by hep^Act.UAS.cUa, Scer\GAL4^GMR.PU

(Tare et al., 2011)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PU has eye disc phenotype, enhanceable by Jra^Asp.B.UAS, Scer\GAL4^GMR.PU

(Tare et al., 2011)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PU has eye phenotype, enhanceable by Jra^Asp.B.UAS, Scer\GAL4^GMR.PU

(Tare et al., 2011)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^Toll-6-D42 has embryonic/larval neuromuscular junction phenotype, enhanceable by Hsap\MAPT^UAS.1N4R, Scer\GAL4^Toll-6-D42

(Folwell et al., 2010)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^Toll-6-D42 has NMJ bouton phenotype, enhanceable by Hsap\MAPT^UAS.1N4R, Scer\GAL4^Toll-6-D42

(Folwell et al., 2010)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^Toll-6-D42 has embryonic/larval neuromuscular junction phenotype, enhanceable by Hsap\MAPT^{R406W.UAS.1N4R}, Scer\GAL4^Toll-6-D42

(Folwell et al., 2010)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^Toll-6-D42 has NMJ bouton phenotype, enhanceable by Hsap\MAPT^{R406W.UAS.1N4R}, Scer\GAL4^Toll-6-D42

(Folwell et al., 2010)

Suppressed by

Statement

Reference

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PU has eye phenotype, suppressible | partially by nej^UAS.Tag:V5, Scer\GAL4^GMR.PU

(Cutler et al., 2015)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PU has lens phenotype, suppressible | partially by nej^UAS.Tag:V5, Scer\GAL4^GMR.PU

(Cutler et al., 2015)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PU has eye photoreceptor cell | third instar larval stage phenotype, suppressible | partially by nej^UAS.Tag:V5, Scer\GAL4^GMR.PU

(Cutler et al., 2015)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PU has axon | third instar larval stage phenotype, suppressible | partially by nej^UAS.Tag:V5, Scer\GAL4^GMR.PU

(Cutler et al., 2015)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PU has eye disc | third instar larval stage phenotype, suppressible | partially by nej^UAS.Tag:V5, Scer\GAL4^GMR.PU

(Cutler et al., 2015)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PU has eye disc | third instar larval stage phenotype, suppressible | partially by nej^{dsRNA.UAS.cKa}, Scer\GAL4^GMR.PU

(Cutler et al., 2015)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PU has eye phenotype, suppressible | partially by nej^ΔQ.UAS, Scer\GAL4^GMR.PU

(Cutler et al., 2015)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PU has lens phenotype, suppressible | partially by nej^ΔQ.UAS, Scer\GAL4^GMR.PU

(Cutler et al., 2015)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PU has eye disc | third instar larval stage phenotype, suppressible | partially by nej^ΔQ.UAS, Scer\GAL4^GMR.PU

(Cutler et al., 2015)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PU has eye phenotype, suppressible | partially by nej^ΔHQ.UAS, Scer\GAL4^GMR.PU

(Cutler et al., 2015)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PU has lens phenotype, suppressible | partially by nej^ΔHQ.UAS, Scer\GAL4^GMR.PU

(Cutler et al., 2015)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PU has eye disc | third instar larval stage phenotype, suppressible | partially by nej^ΔHQ.UAS, Scer\GAL4^GMR.PU

(Cutler et al., 2015)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PU has eye phenotype, suppressible | partially by nej^ΔNZK.UAS, Scer\GAL4^GMR.PU

(Cutler et al., 2015)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PU has lens phenotype, suppressible | partially by nej^ΔNZK.UAS, Scer\GAL4^GMR.PU

(Cutler et al., 2015)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PU has eye disc | third instar larval stage phenotype, suppressible | partially by nej^ΔNZK.UAS, Scer\GAL4^GMR.PU

(Cutler et al., 2015)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PU has eye phenotype, suppressible | partially by nej^KIX.UAS, Scer\GAL4^GMR.PU

(Cutler et al., 2015)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PU has lens phenotype, suppressible | partially by nej^KIX.UAS, Scer\GAL4^GMR.PU

(Cutler et al., 2015)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PU has eye disc | third instar larval stage phenotype, suppressible | partially by nej^KIX.UAS, Scer\GAL4^GMR.PU

(Cutler et al., 2015)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PU has eye phenotype, suppressible | partially by crb^GD14463, Scer\GAL4^GMR.PU

(Steffensmeier et al., 2013)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PU has eye disc phenotype, suppressible | partially by crb^GD14463, Scer\GAL4^GMR.PU

(Steffensmeier et al., 2013)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PU has eye disc phenotype, suppressible | partially by crb^11A22

(Steffensmeier et al., 2013)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PU has eye phenotype, suppressible | partially by crb^11A22

(Steffensmeier et al., 2013)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by crb^{IntraΔERLI.UAS.Tag:MYC}, Scer\GAL4^GMR.PU

(Steffensmeier et al., 2013)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PU has eye disc phenotype, suppressible by crb^{IntraΔERLI.UAS.Tag:MYC}, Scer\GAL4^GMR.PU

(Steffensmeier et al., 2013)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by crb^{IntraY10A.E16A.UAS.Tag:MYC}, Scer\GAL4^GMR.PU

(Steffensmeier et al., 2013)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PU has eye disc phenotype, suppressible by crb^{IntraY10A.E16A.UAS.Tag:MYC}, Scer\GAL4^GMR.PU

(Steffensmeier et al., 2013)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by crb^{IntraY10A.E16A.ΔERLI.UAS.Tag:MYC}, Scer\GAL4^GMR.PU

(Steffensmeier et al., 2013)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PU has eye disc phenotype, suppressible by crb^{IntraY10A.E16A.ΔERLI.UAS.Tag:MYC}, Scer\GAL4^GMR.PU

(Steffensmeier et al., 2013)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PU has eye phenotype, suppressible | partially by BacA\p35^UAS.cHa, Scer\GAL4^GMR.PU

(Tare et al., 2011)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PU has eye disc phenotype, suppressible | partially by BacA\p35^UAS.cHa, Scer\GAL4^GMR.PU

(Tare et al., 2011)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PU has eye phenotype, suppressible | partially by puc^UAS.cMa, Scer\GAL4^GMR.PU

(Tare et al., 2011)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PU has eye disc phenotype, suppressible | partially by puc^UAS.cMa, Scer\GAL4^GMR.PU

(Tare et al., 2011)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PU has eye disc phenotype, suppressible by bsk^DN.UAS, Scer\GAL4^GMR.PU

(Tare et al., 2011)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by bsk^DN.UAS, Scer\GAL4^GMR.PU

(Tare et al., 2011)

NOT suppressed by

Statement

Reference

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PU has eye phenotype, non-suppressible by nej^{dsRNA.UAS.cKa}, Scer\GAL4^GMR.PU

(Cutler et al., 2015)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^GMR.PU has lens phenotype, non-suppressible by nej^{dsRNA.UAS.cKa}, Scer\GAL4^GMR.PU

(Cutler et al., 2015)

Enhancer of

Statement

Reference

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^Toll-6-D42 is an enhancer of embryonic/larval motor neuron phenotype of Hsap\MAPT^UAS.1N4R, Scer\GAL4^Toll-6-D42

(Folwell et al., 2010)

Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^Toll-6-D42 is an enhancer of axon phenotype of Hsap\MAPT^UAS.1N4R, Scer\GAL4^Toll-6-D42

(Folwell et al., 2010)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Co-expression of nej^{Scer\UAS.T:SV5\V5}, nej^ΔQ.Scer\UAS, nej^{ΔHQ.Scer\UAS}, nej^{ΔNZK.Scer\UAS} or nej^KIX.Scer\UAS, but not nej^{dsRNA.Scer\UAS.cKa}, partially rescues the small eye and lens fusion phenotype seen in adult flies expressing Hsap\APP^{Aβ42.Scer\UAS.cUa} under the control of Scer\GAL4^GMR.PU. Co-expression of nej^{Scer\UAS.T:SV5\V5}, nej^ΔQ.Scer\UAS, nej^{ΔHQ.Scer\UAS}, nej^{ΔNZK.Scer\UAS}, nej^KIX.Scer\UAS or nej^{dsRNA.Scer\UAS.cKa} partially suppresses the increased cell death; and co-expression of nej^{Scer\UAS.T:SV5\V5} suppresses the aberrant axonal targeting observed in third instar eye discs of flies expressing Hsap\APP^{Aβ42.Scer\UAS.cUa} under the control of Scer\GAL4^GMR.PU.

Co-expression of nej^{ΔBHQ.Scer\UAS} enhances the eye phenotype of adult flies, enhances the increased cell death and aberrant axonal targeting observed in third instar eye disc of flies expressing Hsap\APP^{Aβ42.Scer\UAS.cUa} under the control of Scer\GAL4^GMR.PU, and results in failure of these flies to eclose.

(Cutler et al., 2015)

A Amph^5E3 mutant background does not affect the subtle rough eye phenotype caused by expression of Hsap\APP^{Aβ42.Scer\UAS.cUa} under the control of Scer\GAL4^elav-C155.

(Chapuis et al., 2013)

Co-expression of crb^GD14463 significantly rescues the eye neurodegeneration phenotype caused by expression of Hsap\APP^{Aβ42.Scer\UAS.cUa} under the control of Scer\GAL4^GMR.PU. The increased cell death phenotype which is seen in the eye imaginal discs of animals expressing Hsap\APP^{Aβ42.Scer\UAS.cUa} under the control of Scer\GAL4^GMR.PU is also significantly suppressed.

crb^11A22 significantly rescues the eye neurodegeneration phenotype caused by expression of Hsap\APP^{Aβ42.Scer\UAS.cUa} under the control of Scer\GAL4^GMR.PU. The increased cell death phenotype which is seen in the eye imaginal discs of animals expressing Hsap\APP^{Aβ42.Scer\UAS.cUa} under the control of Scer\GAL4^GMR.PU is also significantly suppressed.

Co-expression of crb^Scer\UAS.cWa enhances the increased cell death phenotype which is seen in the eye imaginal discs of animals expressing Hsap\APP^{Aβ42.Scer\UAS.cUa} under the control of Scer\GAL4^GMR.PU. The increased cell death phenotype which is seen in the eye imaginal discs of animals expressing Hsap\APP^{Aβ42.Scer\UAS.cUa} under the control of Scer\GAL4^GMR.PU is also significantly enhanced.

Co-expression of either crb^{IntraΔERLI.Scer\UAS.T:Hsap\MYC}, crb^{IntraY10A.E16A.Scer\UAS.T:Hsap\MYC} or crb^{IntraY10A.E16A.ΔERLI.Scer\UAS.T:Hsap\MYC} rescues the adult eye neurodegeneration phenotype seen in animals expressing Hsap\APP^{Aβ42.Scer\UAS.cUa} under the control of Scer\GAL4^GMR.PU. The increased cell death phenotype which is seen in the eye imaginal discs of animals expressing Hsap\APP^{Aβ42.Scer\UAS.cUa} under the control of Scer\GAL4^GMR.PU is also significantly suppressed.

(Steffensmeier et al., 2013)

Co-expression of BacA\p35^Scer\UAS.cHa partially rescues the increase in cell death seen in the third larval instar eye disc of animals expressing Hsap\APP^{Aβ42.Scer\UAS.cUa} under the control of Scer\GAL4^GMR.PU. There is a subtle rescue of the reduced eye size phenotype in the adult, but the neurodegenerative eye phenotype is still present in adult flies.

Co-expression of puc^Scer\UAS.cMa significantly rescues the increase in cell death seen in the third larval instar eye disc of animals expressing Hsap\APP^{Aβ42.Scer\UAS.cUa} under the control of Scer\GAL4^GMR.PU and also strongly rescues the neurodegenerative phenotype of the adult eye.

Co-expression of hep^{Act.Scer\UAS.cUa} enhances the increase in cell death seen in the third larval instar eye disc of animals expressing Hsap\APP^{Aβ42.Scer\UAS.cUa} under the control of Scer\GAL4^GMR.PU and results in adults having a "no-eye" phenotype.

Co-expression of Jra^{Asp.B.Scer\UAS} enhances the increase in cell death seen in the third larval instar eye disc of animals expressing Hsap\APP^{Aβ42.Scer\UAS.cUa} under the control of Scer\GAL4^GMR.PU and results in adults having a severe reduced eye phenotype.

Co-expression of bsk^DN.Scer\UAS dramatically rescues the increase in cell death seen in the third larval instar eye disc of animals expressing Hsap\APP^{Aβ42.Scer\UAS.cUa} under the control of Scer\GAL4^GMR.PU and also strongly rescues the reduced size of the adult eye.

(Tare et al., 2011)

Co-expression of Hsap\APP^{Aβ42.Scer\UAS.cUa} with Hsap\MAPT^{Scer\UAS.1N4R} under the control of Scer\GAL4^Toll-6-D42 enhances the axonal transport phenotype resulting from the expression of Hsap\MAPT^{Scer\UAS.1N4R} alone.

Co-expression of Hsap\APP^{Aβ42.Scer\UAS.cUa} with Hsap\MAPT^{Scer\UAS.1N4R} under the control of Scer\GAL4^Toll-6-D42 exacerbates the neuromuscular junction (NMJ) aberrations seen in mutants expressing any one of the transgenes alone, with more evidence of both "satellite" boutons and thinning of the inter-bouton regions.

Co-expression of Hsap\APP^{Aβ42.Scer\UAS.cUa} with Hsap\MAPT^{R406W.Scer\UAS.1N4R} under the control of Scer\GAL4^Toll-6-D42 exacerbates the neuromuscular junction (NMJ) aberrations seen in mutants expressing Hsap\APP^{Aβ42.Scer\UAS.cUa} alone resulting in a very extreme form of the phenotype.

Co-expression of Hsap\MAPT^{Scer\UAS.1N4R} and Hsap\APP^{Aβ42.Scer\UAS.cUa} under the control of Scer\GAL4^unspecified enhances the locomotor impairment of flies expressing Scer\GAL4^unspecified>Hsap\MAPT^{Scer\UAS.1N4R} alone. As the double transgenic flies age, their climbing abilities steadily deteriorate.

Co-expression of Hsap\MAPT^{Scer\UAS.1N4R} and Hsap\APP^{Aβ42.Scer\UAS.cUa} under the control of Scer\GAL4^unspecified enhances the longevity phenotypes that are seen in flies expressing any of the two transgenes alone. LiCl treatment ameliorates the survival defects.

(Folwell et al., 2010)

Complementation and Rescue Data

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Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Aβ42

(Panikker et al., 2018)

Hsap\APP^{Aβ42.Scer\UAS.cUa}

Hsap\APP^{Aβ42.UAS.cUa}

Name Synonyms

Secondary FlyBase IDs

References (18)

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