FB2025_01 , released February 20, 2025
Allele: Dmel\scaf612M9
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General Information
Symbol
Dmel\scaf612M9
Species
D. melanogaster
Name
FlyBase ID
FBal0296229
Feature type
allele
Associated gene
Dmel\scaf6
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Nucleotide substitution: C?T.

    (Hayashi et al., 2014)

    Amino acid replacement: Q560term.

    (Hayashi et al., 2014)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    point_mutation
    3L:17,038,382..17,038,382 [-]
    Nucleotide change:

    C17038382T

    Reported nucleotide change:

    C?T

    Amino acid change:

    Q560term | scaf6-PA

    Reported amino acid change:

    Q560term

    (Hayashi et al., 2014)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        scaf612M9/Df(3L)ED4674 animals live until the late pupal stage, but rarely eclose.

        (Hayashi et al., 2014)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Rescued by

        scaf612M9 is rescued by scaf6+tCH322-104B15

        (Hayashi et al., 2014)
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer

        Associated with: a second lesion located between 74E--80B.

        (Hayashi et al., 2014)

        The "12M9" chromosome contains two lesions which interact in affecting transposon silencing during oogenesis. The distal mutation, scaf612M9, causes weak transposon activation (measured by the mean level of HeT-A mRNA), which is enhanced by the proximal mutation (which is located between 74E--80B). The proximal mutation has no apparent maternal phenotype in the absence of scaf612M9. Germline clones homozygous for both lesions have defective germ cell maintenance such that no developing egg chambers remain 10 days after clone induction.

        (Hayashi et al., 2014)
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        12M9
        (Hayashi et al., 2014)
        scaf612M9
        Name Synonyms
        Secondary FlyBase IDs
          References (1)