FlyBase Allele Report: Dmel\foxo[UAS.cUa]

General Information

Symbol

Dmel\foxo^UAS.cUa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Unknown

FlyBase ID

FBal0296350

Feature type

allele

Associated gene

Dmel\foxo

Associated Insertion(s)

Carried in Construct

P{UAS-foxo.U}

Also Known As

UAS-Foxo, UAS-dfoxO

Key Links

Transgenic product class

wild_type

(Tixier et al., 2013)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Tixier et al., 2013)

Mutagen

in vitro construct

(Tixier et al., 2013)

Progenitor genotype

Carried in construct

P{UAS-foxo.U}

Cytology

Description

UAS regulatory sequences drive expression of foxo.

(Tixier et al., 2013)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

foxo

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Huntington's disease

modeled by Hsap\HTT^{N548.Q128.UAS}

(Martin et al., 2021)

ameliorates Alzheimer's disease 1

modeled by Hsap\APP^{Aβ42.UAS.cUa}

(Cheng et al., 2021)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

embryonic myoblast, with Scer\GAL4^kirre.PU

(Tixier et al., 2013)

larval somatic muscle cell, with Scer\GAL4^kirre.PU

(Tixier et al., 2013)

muscle cell of A1-7 dorsal acute muscle 1, with Scer\GAL4^kirre.PU

(Tixier et al., 2013)

segment border muscle cell, with Scer\GAL4^kirre.PU

(Tixier et al., 2013)

Detailed Description

Statement

Reference

Embryos expressing foxo^Scer\UAS.cUa under the control of Scer\GAL4^kirre.PU show a significant reduction in the size of the segmental border muscle and the DA1 muscle, and also in the number of nuclei present in these muscles.

(Tixier et al., 2013)

Embryos expressing foxo^Scer\UAS.cUa under the control of Scer\GAL4^kirre.PU have smaller muscles than normal and unfused myoblasts are present.

(Tixier et al., 2013)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

foxo^UAS.cUa, Scer\GAL4^Bx-MS1096-KE is an enhancer of visible | adult stage phenotype of Lsd-2^GD14108, Scer\GAL4^Bx-MS1096-KE

(Binh et al., 2019)

foxo^UAS.cUa, Scer\GAL4^Bx-MS1096-KE is an enhancer of increased cell death | third instar larval stage phenotype of Lsd-2^GD14108, Scer\GAL4^Bx-MS1096-KE

(Binh et al., 2019)

Suppressor of

Statement

Reference

foxo^UAS.cUa, Scer\GAL4^{repo.Switch.2301} is a suppressor | partially of short lived | RU486 conditional phenotype of Hsap\HTT^{N548.Q128.UAS}, Scer\GAL4^{repo.Switch.2301}

(Martin et al., 2021)

foxo^UAS.cUa, Scer\GAL4^ey.PU is a suppressor | partially of neoplasia | larval stage phenotype of ND-42^GD6220, Scer\GAL4^ey.PU

(Choo et al., 2015)

Phenotype Manifest In

Enhancer of

Statement

Reference

foxo^UAS.cUa, Scer\GAL4^Bx-MS1096-KE is an enhancer of wing phenotype of Lsd-2^GD14108, Scer\GAL4^Bx-MS1096-KE

(Binh et al., 2019)

foxo^UAS.cUa, Scer\GAL4^Bx-MS1096-KE is an enhancer of wing pouch | third instar larval stage phenotype of Lsd-2^GD14108, Scer\GAL4^Bx-MS1096-KE

(Binh et al., 2019)

Suppressor of

Statement

Reference

foxo^UAS.cUa, Scer\GAL4^ey.PU is a suppressor | partially of eye disc phenotype of ND-42^GD6220, Scer\GAL4^ey.PU

(Choo et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

foxo^Scer\UAS.cUa

foxo^UAS.cUa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Unknown

Secondary FlyBase IDs

References (13)

Report Sections

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