FB2025_01 , released February 20, 2025
Allele: Dmel\InRDN.UAS.cUa
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General Information
Symbol
Dmel\InRDN.UAS.cUa
Species
D. melanogaster
Name
FlyBase ID
FBal0296352
Feature type
allele
Associated gene
Dmel\InR
Associated Insertion(s)
Carried in Construct
P{UAS-InR.DN.U}
Also Known As
UAS-InRDN, UAS-InR DN
Key Links
Transgenic product class
dominant_negative_variant
(Tixier et al., 2013)
Mutagen
Nature of the Allele
Transgenic product class
dominant_negative_variant
(Tixier et al., 2013)
Mutagen
in vitro construct
(Tixier et al., 2013)
Progenitor genotype
Carried in construct
P{UAS-InR.DN.U}
Cytology
Description

UAS regulatory sequences drive expression of a dominant-negative form of InR.

(Tixier et al., 2013)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
InR
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Adults expressing InRDN.UAS.cUa under the control of Scer\GAL4Toll-6-D42 show neuromuscular junctions with fewer active zones.

      (Jarabo et al., 2021)

      Expression of InRDN.UAS.cUa under the control of Scer\GAL4en.PU leads to a reduction in the posterior compartment of wing size relative to the anterior one. Also, its expression under the control of Scer\GAL4salm.EPv leads to a smaller wing area included between the veins L2 and L5.

      (Vega-Cuesta et al., 2020)

      Expression of InRDN.UAS.cUa under the control of Scer\GAL4Gr28b.b.4.7 in adults does not affect food intake of starved or satiated flies, compared to controls.

      (Zhan et al., 2016)

      Expression of InRDN.Scer\UAS.cUa under the control of Scer\GAL4Mef2.PR has no effect on heart development in the embryo.

      Expression of InRDN.Scer\UAS.cUa under the control of Scer\GAL4elav.PU has no effect on nervous system development in the embryo.

      Expression of InRDN.Scer\UAS.cUa under the control of Scer\GAL469B has no effect on epidermal development in the embryo.

      Embryos expressing InRDN.Scer\UAS.cUa under the control of Scer\GAL4kirre.PU show a significant reduction in the size of the segmental border muscle and the DA1 muscle, and also in the number of nuclei present in these muscles.

      (Tixier et al., 2013)

      Embryos expressing InRDN.Scer\UAS.cUa under the control of Scer\GAL4kirre.PU have thinner muscles than normal and unfused myoblasts are present.

      (Tixier et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      The additional co-expression of InRDN.Scer\UAS.cUa modifies the fully penetrant rough eye phenotype that results from the co-expression of HPV18\E6Scer\UAS.T:Hsap\MYC and Hsap\UBE3AScer\UAS.cRa under the control of Scer\GAL4GMR.PU, leading to severe eye necrosis.

      (Padash Barmchi et al., 2016)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      InRDN.Scer\UAS.cUa
      InRDN.UAS.cUa
      InRDN
      (Tixier et al., 2013, Tixier et al., 2013)
      Name Synonyms
      Secondary FlyBase IDs
        References (13)