FB2025_05 , released December 11, 2025
Allele: Dmel\ShrmΔ11
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General Information
Symbol
Dmel\ShrmΔ11
Species
D. melanogaster
Name
FlyBase ID
FBal0296502
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
ShroomΔ11
Key Links
Nature of the Allele
Cytology
Description

P-element mediated recombination between P{SUPor-P}KG04646 and P{EPgy2}CG8613EY06332 has resulted in deletion of part of the Shroom coding region. The 5' breakpoint is between 10,217,297 and 10,238,252 and the 3' breakpoint is between 10,238,326 and 10,239,796. The allele retains sequences immediately outside of the two P elements as well as sequences in the 5' coding region, likely because of gap repair. Sequences within the last three exons of Shroom, which encode the Rho-kinase-binding domain, are removed.

Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

ShroomΔ11 mutant stage 8 embryos have reduced convergent extension resulting in a smaller increase in tissue length to width ratio compared to wild type. In contrast, tissue length along the anterior posterior axis is only slightly reduced. ShroomΔ11 mutants exhibit defects in convergent extension cell rearrangement: there is a strong reduction in rosette behaviors (resulting from the contraction of multiple consecutive edges), but little change in local neighbour exchange (resulting from single edge contraction events). Cells in ShroomΔ11 mutants have more neighbours on average midway through elongation. Intercalating cells in ShroomΔ11 mutant embryos have a slightly larger apical area during elongation, with no difference between wild type and mutant cells before elongation.

External Data
Interactions
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Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (3)