FB2020_03, released Jun 16, 2020

Allele: Dmel\jetset

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General Information
Symbol
Dmel\jetset
Species
D. melanogaster
Name
FlyBase ID
FBal0296640
Feature type
allele
Associated gene
Dmel\jet
Associated Insertion(s)
Carried in Construct
Genomic Maps
Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Lamba et al., 2014)
Mutagen
ethyl methanesulfonate
(Lamba et al., 2014)
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
2L:4,948,991..4,948,991 [-]
Nucleotide change:

C4948991T

Amino acid change:

T228I | jet-PA; T228I | jet-PB

Reported amino acid change:

T228I

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Lamba et al., 2014)
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
       
      Progenitor genotype
      Cytology
      Nature of the lesion
      Statement
      Reference

      Amino acid replacement: T228I.

      (Lamba et al., 2014)
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mutant flies remain robustly rhythmic under constant light conditions, in construct to wild-type controls.

      Behavioral phase shifts after short light pulses applied early (ZT15) or late (ZT21) at night are almost completely abolished in mutant flies.

      (Lamba et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      jetc

      (Lamba et al., 2014)

      jetr

      (Lamba et al., 2014)
      Rescued by

      jetset is rescued by Scer\GAL4tim.PE/jetUAS.cKa

      (Lamba et al., 2014)

      jetset is rescued by jetUAS.cKa/Scer\GAL4Mai179

      (Lamba et al., 2014)

      jetset is rescued by Scer\GAL4Dvir\Pdf.1.9/jetUAS.cKa

      (Lamba et al., 2014)
      Partially rescued by

      jetset is partially rescued by jetUAS.cKa/Scer\GAL4P2.4.Pdf

      (Lamba et al., 2014)
      Not rescued by

      jetset is not rescued by jetUAS.cKa/Scer\GAL4Clk.4.1M

      (Lamba et al., 2014)

      jetset is not rescued by Scer\GAL4dimm-929/jetUAS.cKa

      (Lamba et al., 2014)

      jetset is not rescued by jetUAS.cKa/Scer\GAL4Mai179/Scer\GAL80Pdf.PS

      (Lamba et al., 2014)
      Comments

      Expression of jetScer\UAS.cKa under the control of either Scer\GAL4tim.PE, Scer\GAL4Dvir\Pdf.1.9 or Scer\GAL4Mai179 in jetset flies rescues the reduction in phase shifts in response to short light pulses applied early (ZT15) or late (ZT21) at night. Expression under the control of either Scer\GAL4Clk.4.1M or Scer\GAL4dimm-929 fails to rescue this defect, while expression under the control of Scer\GAL4P2.4.Pdf results in slight rescue at ZT15, but not at ZT21.

      Expression of jetScer\UAS.cKa under the control of Scer\GAL4Mai179 in the presence of Scer\GAL80Pdf.PS fails to rescue the reduction in phase shifts in response to short light pulses at ZT15 or ZT21.

      (Lamba et al., 2014)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      jetset
      (Lamba et al., 2014)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)