FlyBase Allele Report: Dmel\Snr1[RNAi.UAS.cUa]

General Information

Symbol

Dmel\Snr1^RNAi.UAS.cUa

Species

D. melanogaster

Name

FlyBase ID

FBal0296682

Feature type

allele

Associated gene

Dmel\Snr1

Associated Insertion(s)

Carried in Construct

P{UAS-Snr1.RNAi.U}

Also Known As

UAS-snr1 dsRNA

Key Links

Transgenic product class

RNAi_reagent

(FlyBase Curators, 2025-)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(FlyBase Curators, 2025-)

Mutagen

in vitro construct

(FlyBase Curators, 2025-)

Progenitor genotype

Carried in construct

P{UAS-Snr1.RNAi.U}

Cytology

Description

UAS regulatory sequences drive expression of an RNAi construct targeting Snr1.

(FlyBase Curators, 2025-)

FlyBase curator comment: this entry represents a transgenic construct where the particular construct used cannot be determined.

(FlyBase Curators, 2025-)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Snr1

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of atypical teratoid rhabdoid tumor

CEA

(Jeibmann et al., 2014)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of atypical teratoid rhabdoid tumor

is ameliorated by CycD^RNAi.UAS.cUa

(Jeibmann et al., 2014)

is ameliorated by Mer^GD1484

(Jeibmann et al., 2014)

is ameliorated by kibra^RNAi.UAS.cUa

(Jeibmann et al., 2014)

is ameliorated by ex^VDRC.cUa

(Jeibmann et al., 2014)

is ameliorated by ex^RNAi.UAS.cUa

(Jeibmann et al., 2014)

is ameliorated by ci^RNAi.UAS.cUa

(Jeibmann et al., 2014)

is ameliorated by ci^RNAi.UAS.cUa

(Jeibmann et al., 2014)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

larval brain, with Scer\GAL4^repo.PU

(Jeibmann et al., 2014)

larval brain, with Scer\GAL4^αTub84B.PL

(Jeibmann et al., 2014)

Detailed Description

Statement

Reference

While ubiquitous expression of Snr1^VDRC.cUa under the control of Scer\GAL4^αTub84B.PL inevitably results in larval death (L2 stage), glial-specific expression of Snr1^VDRC.cUa under the control of Scer\GAL4^repo.PU is associated with death at the pupal stage of development.

Ubiquitous and glial-specific expression of Snr1^VDRC.cUa results in increased volume of the larval fly brain, which is associated with increased cell proliferation.

(Jeibmann et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Scer\GAL4^αTub84B.PL, Snr1^RNAi.UAS.cUa has lethal - all die before end of second instar larval stage phenotype, suppressible by Mer^GD1484, Scer\GAL4^αTub84B.PL

(Jeibmann et al., 2014)

Scer\GAL4^repo.PU, Snr1^RNAi.UAS.cUa has lethal - all die before end of P-stage phenotype, suppressible by CycD^RNAi.UAS.cUa, Scer\GAL4^repo.PU

(Jeibmann et al., 2014)

Scer\GAL4^repo.PU, Snr1^RNAi.UAS.cUa has lethal - all die before end of P-stage phenotype, suppressible by ci^RNAi.UAS.cUa/Scer\GAL4^repo.PU

(Jeibmann et al., 2014)

Scer\GAL4^repo.PU, Snr1^RNAi.UAS.cUa has lethal - all die before end of P-stage phenotype, suppressible by Scer\GAL4^repo.PU/kibra^RNAi.UAS.cUa

(Jeibmann et al., 2014)

Scer\GAL4^repo.PU, Snr1^RNAi.UAS.cUa has lethal - all die before end of P-stage phenotype, suppressible by ex^RNAi.UAS.cUa/Scer\GAL4^repo.PU

(Jeibmann et al., 2014)

Phenotype Manifest In

Suppressed by

Statement

Reference

Dcr-2^UAS.cDa, Scer\GAL4^repo.PU, Snr1^RNAi.UAS.cUa has larval brain phenotype, suppressible by kibra^RNAi.UAS.cUa, Scer\GAL4^repo.PU

(Jeibmann et al., 2014)

Dcr-2^UAS.cDa, Scer\GAL4^repo.PU, Snr1^RNAi.UAS.cUa has larval brain phenotype, suppressible by ex^RNAi.UAS.cUa, Scer\GAL4^repo.PU

(Jeibmann et al., 2014)

Other

Statement

Reference

Dcr-2^UAS.cDa, Scer\GAL4^repo.PU, Snr1^RNAi.UAS.cUa has larval brain phenotype

(Jeibmann et al., 2014)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of Dcr-2^Scer\UAS.cDa and Snr1^VDRC.cUa both under the control of Scer\GAL4^repo.PU results in increased larval brain volume.

Expression of Scer\GAL4^repo.PU>kibra^VDRC.cUa results in reduction of the increased brain volume observed upon co-expression of Dcr-2^Scer\UAS.cDa and Snr1^VDRC.cUa.

Expression of Scer\GAL4^repo.PU>ex^VDRC.cUa results in reduction of the increased brain volume observed upon co-expression of Dcr-2^Scer\UAS.cDa and Snr1^VDRC.cUa.

(Jeibmann et al., 2014)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Snr1^RNAi.UAS.cUa

Snr1^VDRC.cUa

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

Open Close