FlyBase Allele Report: Dmel\LanB1[S0473]

General Information

Symbol

Dmel\LanB1^S0473

Species

D. melanogaster

Name

FlyBase ID

FBal0298009

Feature type

allele

Associated gene

Dmel\LanB1

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - molecular evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Hollfelder et al., 2014)

Mutagen

ethyl methanesulfonate

(Hollfelder et al., 2014)

Progenitor genotype

Cytology

Description

Amino acid replacement: W465term.

(Hollfelder et al., 2014)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2L:7,816,341..7,816,341 [+]

Nucleotide change:

G7816341A

Amino acid change:

W465term | LanB1-PA; W465term | LanB1-PB

Reported amino acid change:

W465term

Comment:

G to A nucleotide change at the second or third position of the Trp codon leads to a nonsense mutation (exact site of mutation unspecified). Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Hollfelder et al., 2014)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Mutant embryos show alary muscle and dorsal vessel defects, and severe midgut constriction defects and visceral mesoderm phenotypes. They also show pronounced defects in the heart and in somatic body wall muscles.

(Hollfelder et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

Col4a1^S3064, LanB1^S0473 has partially lethal - majority die phenotype

(Hollfelder et al., 2014)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

603850

y¹ w^*; P{org-1.SM-RFP}Jon25Bi^18a LanB1^S0473 P{tinC-GFP}cn^13b P{HLH54F.LVM-RFP}Sin3A^16b/CyO, P{GAL4-twi.G}2.2, P{UAS-2xEGFP}AH2.2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

LanB1^S0473

(Hollfelder et al., 2014)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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