FlyBase Allele Report: Dmel\Flacc[A]

General Information

Symbol

Dmel\Flacc^A

Species

D. melanogaster

Name

FlyBase ID

FBal0298890

Feature type

allele

Associated gene

Dmel\Flacc

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - molecular evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

hypomorphic allele - molecular evidence

(Guo et al., 2018)

Mutagen

ethyl methanesulfonate

(Graves et al., 2020, Yamamoto et al., 2013-)

Progenitor genotype

Cytology

Description

Amino acid replacement: N782S.

(Graves et al., 2020, Yamamoto et al., 2013-)

A frameshift mutation at amino acid 782.

(Guo et al., 2018)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

delins

X:18,890,853..18,890,860 [-]

Comment:

A deletion of 8 bases and insertion of 6 (CAGGAG) bases in Flacc^A leads to a net loss of two bases and a frameshift at amino acid 80 of Flacc.

Inserted_sequence:

CAGGAG

(Guo et al., 2018)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

flightless | male

(Guo et al., 2018)

lethal - all die during pupal stage | male

(Guo et al., 2018)

visible | adult stage | male

(Guo et al., 2018)

Phenotype Manifest In

Detailed Description

Statement

Reference

Flacc^A/Y flies die at pupal stage when kept in stock over the FM7c balancer but crossing out the Flacc^A/FM7c females to yw/Y (wild-type) males does yield some viable Flacc^A/Y male flies which however display highly penetrant wing posture defects (held-out wings) and are almost completely flightless.

(Guo et al., 2018)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

Flacc^A, Sxl[+]/Sxl^fP7B0 has partially lethal | female | parental effect phenotype

(Guo et al., 2018)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

When Flacc^A heterozygous mothers are crossed to Sxl^fP7B0/Y fathers only 38% of the expected Sxl^fP7B0/+ female progeny survive to adulthood.

(Guo et al., 2018)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Rescued by: Dp(1;3)DC354.

(Yamamoto et al., 2013-)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

57081

y¹ w^* Flacc^A P{neoFRT}19A/FM7c, P{GAL4-Kr.C}DC1, P{UAS-GFP.S65T}DC5, sn⁺

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

CG7358^A

(Yamamoto et al., 2013-)

Flacc^A

(Graves et al., 2020)

XE33A

(Graves et al., 2020)

XMSY014

(Graves et al., 2020)

xio^A

(Guo et al., 2018)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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