Open Close
General Information
Symbol
Dmel\FlaccC
Species
D. melanogaster
Name
FlyBase ID
FBal0298891
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Nucleotide change:

T18891009A

Reported nucleotide change:

A?T

Amino acid change:

L730term | CG7358-PA; L730term | CG7358-PB; L730term | CG7358-PC

Amino acid change:

L730term | Flacc-PA; L730term | Flacc-PB; L730term | Flacc-PC

Reported amino acid change:

L730term

Reported amino acid change:

?729 term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

Comment:

The published sequence traces (from the noncoding strand) indicate that the nonsense mutation in FlaccCis at amino acid 730 but the text reports it at amino acid 729.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Nucleotide substitution: A?T.

Amino acid replacement: ?729term.

Amino acid replacement: L730term.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

FlaccC/Y flies are pharate lethal, with some flies half way out of the pupal case.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement
Reference

FlaccC, nito[+], nito1, Flacc[+] is a suppressor | partially of lethal | female phenotype of vir2f

NOT Suppressor of
Statement
Reference

FlaccC/Flacc[+] is a non-suppressor of lethal | female phenotype of vir2f

Other
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

Df(2L)BSC209/+;FlaccC/+ double heterozygous females show significantly reduced viability compared to Df(2L)BSC209 single heterozygotes.

The complete lethality of vir2f homozygous females cannot be suppressed by combination with a single copy of nito1 or FlaccC individually but heterozygosity for both does partially restore viability of the vir2f/vir2f females.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (3)