FB2025_01 , released February 20, 2025
Allele: Dmel\FlaccC
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General Information
Symbol
Dmel\FlaccC
Species
D. melanogaster
Name
FlyBase ID
FBal0298891
Feature type
allele
Associated gene
Dmel\Flacc
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - molecular evidence

(Guo et al., 2018)
Mutagen
ethyl methanesulfonate
(Graves et al., 2020, Yamamoto et al., 2013-)
Progenitor genotype
Cytology
Description

Amino acid replacement: L730term.

(Graves et al., 2020, Yamamoto et al., 2013-)

Nucleotide substitution: A?T.

(Guo et al., 2018)

Amino acid replacement: ?729term.

(Guo et al., 2018)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:18,891,009..18,891,009 [-]
Nucleotide change:

T18891009A

Reported nucleotide change:

A?T

Amino acid change:

L730term | Flacc-PA; L730term | Flacc-PB; L730term | Flacc-PC

Reported amino acid change:

L730term

Reported amino acid change:

?729 term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

Comment:

The published sequence traces (from the noncoding strand) indicate that the nonsense mutation in FlaccCis at amino acid 730 but the text reports it at amino acid 729.

(Guo et al., 2018, Haelterman et al., 2014, Yamamoto et al., 2013-)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      FlaccC/Y flies are pharate lethal, with some flies half way out of the pupal case.

      (Guo et al., 2018)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      FlaccC, nito[+], nito1, Flacc[+] is a suppressor of lethal | female phenotype of vir2f

      (Knuckles et al., 2018)
      NOT Suppressor of
      Statement
      Reference

      FlaccC/Flacc[+] is a non-suppressor of lethal | female phenotype of vir2f

      (Knuckles et al., 2018)
      Other
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Df(2L)BSC209/+;FlaccC/+ double heterozygous females show significantly reduced viability compared to Df(2L)BSC209 single heterozygotes.

      The complete lethality of vir2f homozygous females cannot be suppressed by combination with a single copy of nito1 or FlaccC individually but heterozygosity for both does partially restore viability of the vir2f/vir2f females.

      (Knuckles et al., 2018)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments

      Rescued by: Dp(1;3)DC354.

      (Yamamoto et al., 2013-)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (6)
      Reported As
      Symbol Synonym
      CG7358C
      (Knuckles et al., 2018, Yamamoto et al., 2013-)
      FlaccC
      (Graves et al., 2020)
      XLYF057
      (Graves et al., 2020)
      XM26C
      (Graves et al., 2020)
      flaccC
      (Knuckles et al., 2018)
      xioC
      (Guo et al., 2018)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)