FlyBase Allele Report: Dmel\dlg1[A]

General Information

Symbol

Dmel\dlg1^A

Species

D. melanogaster

Name

FlyBase ID

FBal0298896

Feature type

allele

Associated gene

Dmel\dlg1

Associated Insertion(s)

Carried in Construct

Also Known As

dlg^A

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - molecular evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Ventura et al., 2020)

Mutagen

ethyl methanesulfonate

(Graves et al., 2020, Yamamoto et al., 2013-)

Progenitor genotype

Cytology

Description

Amino acid replacement: Q551term.

(Graves et al., 2020)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

X:11,398,330..11,398,330 [+]

Nucleotide change:

C11398330T

Amino acid change:

Comment:

Nonsense mutation (CAA to TAA) mapped to r6 coordinate X:11 ,398,330.

(Haelterman, 2015.3.20)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cell polarity | oogenesis | somatic clone

(Lu et al., 2021)

sterile, with dlg1^{S4A.Ubi-p63E.GFP}

(Lu et al., 2021)

sterile, with dlg1^{ΔGUK.Ubi-p63E.GFP}

(Lu et al., 2021)

viable, with dlg1^{S4A.Ubi-p63E.GFP}

(Lu et al., 2021)

viable, with dlg1^{ΔGUK.Ubi-p63E.GFP}

(Lu et al., 2021)

Phenotype Manifest In

follicle cell

(Lu et al., 2021)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

dlg1^A is rescued by dlg1^{ΔGUK.Ubi-p63E.GFP}

(Lu et al., 2021)

dlg1^A is rescued by dlg1^{ΔPDZ.S4A.Ubi-p63E.GFP}

(Lu et al., 2021)

dlg1^A is rescued by dlg1^{ΔPDZ.Ubi-p63E.GFP}

(Lu et al., 2021)

dlg1^A is rescued by dlg1^{S4A.Ubi-p63E.GFP}

(Lu et al., 2021)

dlg1^A is rescued by dlg1^Ubi-p63E.GFP

(Lu et al., 2021)

Partially rescued by

dlg1^A is partially rescued by dlg1^{ΔGUK.m30.Ubi-p63E.GFP}

(Lu et al., 2021)

Not rescued by

dlg1^A is not rescued by dlg1^{ΔGUK.S4A.Ubi-p63E.GFP}

(Lu et al., 2021)

dlg1^A is not rescued by dlg1^{ΔPDZ.KR15Q.Ubi-p63E.GFP}

(Lu et al., 2021)

dlg1^A is not rescued by dlg1^{ΔPDZ.KR6Q.Ubi-p63E.GFP}

(Lu et al., 2021)

dlg1^A is not rescued by dlg1^{ΔPDZ.m30.Ubi-p63E.GFP}

(Lu et al., 2021)

dlg1^A is not rescued by dlg1^{KR6Q.Ubi-p63E.GFP}

(Lu et al., 2021)

dlg1^A is not rescued by dlg1^{m30.Ubi-p63E.GFP}

(Lu et al., 2021)

Comments

Rescued by: Dp(1;3)DC238.

(Haelterman et al., 2014, Yamamoto et al., 2013-)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

57086

y¹ w^* dlg1^A P{neoFRT}19A/FM7c, P{GAL4-Kr.C}DC1, P{UAS-GFP.S65T}DC5, sn⁺

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

XDSY001

(Graves et al., 2020)

XM03A

(Graves et al., 2020)

dlg1^A

(Luedke et al., 2024, Chen et al., 2018, Haelterman, 2015.3.20, Yamamoto et al., 2013-)

dlg^A

(Lu et al., 2021, Graves et al., 2020, Ventura et al., 2020)

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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