FB2025_01 , released February 20, 2025
Allele: Dmel\dwgA
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General Information
Symbol
Dmel\dwgA
Species
D. melanogaster
Name
FlyBase ID
FBal0298898
Feature type
allele
Associated gene
Dmel\dwg
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Graves et al., 2020, Yamamoto et al., 2013-)
Progenitor genotype
Cytology
Description

Amino acid replacement: C363S.

(Graves et al., 2020, Haelterman et al., 2014, Yamamoto et al., 2013-)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:2,729,261..2,729,261 [+]
Nucleotide change:

T2729261A

Amino acid change:

C363S | dwg-PA

Reported amino acid change:

C363S

Comment:

A nucleotide change at the first or second position of the Cys codon leads to a Ser mutation (base change unspecified).

(Haelterman et al., 2014, Yamamoto et al., 2013-)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      dwg8

      (Haelterman et al., 2014)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      Lethality of the 'dwg[A]' chromosome is not rescued by a duplication carrying dwg (Dp(1;3)DC406) suggesting the presence of a second-site lethal mutation.

      (Haelterman et al., 2014)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      XGSY203
      (Graves et al., 2020)
      XM11A
      (Graves et al., 2020)
      dwgA
      (Graves et al., 2020, Yamamoto et al., 2013-)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)