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General Information
Symbol
Dmel\vtdNC.UASp.Tag:MYC
Species
D. melanogaster
Name
FlyBase ID
FBal0299646
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference
UASp regulatory sequences drive expression of a mutant form of vtd which contains the amino acid replacements R175A and R474A. These mutations are within the two EXXR separase consensus sequences present in the protein and should result in a separase-resistant variant of vtd. The protein is tagged at the C-terminal end with 10 copies of Tag:MYC.
Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
Females expressing vtdNC.Scer\UAS.P\T.T:Hsap\MYC under the simultaneous control of Scer\GAL4otu.T:Hsim\VP16, Scer\GAL4nos.PG and Scer\GAL4nos.UTR.T:Hsim\VP16 are almost completely sterile. The meiotic divisions appear to be normal, but mitotic divisions in early embryos derived from these females are severely affected. Many embryos contain only a single DNA mass. Prominent anaphase bridges and chromosome stretching are seen.
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
vtdNC.Scer\UAS.P\T.T:Hsap\MYC
vtdNC.UASp.Tag:MYC
Name Synonyms
Secondary FlyBase IDs
    References (1)