FB2021_01, released Feb 18, 2021

Allele: Dmel\bratΔB-boxes.UAS.Tag:MYC

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General Information
Symbol
Dmel\bratΔB-boxes.UAS.Tag:MYC
Species
D. melanogaster
Name
FlyBase ID
FBal0299652
Feature type
allele
Associated gene
Dmel\brat
Associated Insertion(s)
Carried in Construct
P{UAS-brat.ΔB-boxes.myc}
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
in vitro construct - regulatory fusion
(Komori et al., 2014)
in vitro construct - coding region fusion
(Komori et al., 2014)
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
       
      Progenitor genotype
      Carried in construct
      P{UAS-brat.ΔB-boxes.myc}
      Cytology
      Nature of the lesion
      Statement
      Reference

      UASt regulatory sequences drive expression of a deleted form of brat which lacks both B-box domains. The protein is tagged with Tag:MYC.

      (Komori et al., 2014)
      Allele components
      Product class / Tool use(s)
      Regulatory region(s)
      UASt
      Encoded product / tool
      brat
      Tagged with
      Tag:MYC
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      bratΔB-boxes.UAS.Tag:MYC/Scer\GAL4VP16.nos.UTR rescues Df(2L)Exel8040/bratfs1

      (Komori et al., 2014)
      Fails to rescue

      bratΔB-boxes.UAS.Tag:MYC/Scer\GAL4wor.PA fails to rescue brat11/Df(2L)Exel8040

      (Komori et al., 2014)
      Comments

      Expression of bratΔB-boxes.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4wor.PA fails to suppress the supernumerary type II neuroblast phenotype seen in brat11/Df(2L)Exel8040 larval brains.

      Expression of bratΔB-boxes.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4nos.UTR.T:Hsim\VP16 rescues the defects in abdominal segmentation seen in bratfs1/Df(2L)Exel8040 embryos.

      (Komori et al., 2014)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      bratΔB-boxes.Scer\UAS.T:Hsap\MYC
      bratΔB-boxes.UAS.Tag:MYC
      Name Synonyms
      Secondary FlyBase IDs
        References (2)