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General Information
Symbol
Dmel\robo1ΔC.UAS.Tag:MYC
Species
D. melanogaster
Name
FlyBase ID
FBal0300849
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of a truncated form of robo1, which lacks all but 67 amino acid residues of the cytoplasmic domain. The protein is tagged at the C-terminal end with 6 copies of Tag:MYC.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of robo1ΔC.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4elav.PLu in embryos results in ectopic crossing of the midline by Fas2-positive axons in approximately one-third of segments.

Overexpression of roboΔC.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4elav.PLu leads to defects in longitudinal axon guidance. About 2.2. defects are seen per animal and about 20% of segments exhibit defects.

Single copies of robo1ΔC.Scer\UAS.T:Hsap\MYC driven by either Scer\GAL4elav.PLu or Scer\GAL4ftz.ng produce no detectable phenotype. When two copies are driven by Scer\GAL4elav.PLu, axons of the medial-most Fas2 expressing longitudinal pathway can be seen inappropriately crossing the midline. A similar but weaker phenotype is seen when robo1ΔC.Scer\UAS.T:Hsap\MYC is driven by Scer\GAL4ftz.ng.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (5)
Reported As
Symbol Synonym
fra::robo1Scer\UAS.RΔC.T:Hsap\MYC
fra::roboScer\UAS.RΔC.T:Hsap\MYC
robo1ΔC.Scer\UAS.T:Hsap\MYC
robo1ΔC.UAS.Tag:MYC
roboΔC.Scer\UAS.T:Hsap\MYC
Name Synonyms
Secondary FlyBase IDs
  • FBal0120369
  • FBal0098247
References (4)